Colin Conine

Selective RNA sequestration in biomolecular condensates directs cell fate transitions - Nature Biotechnology Stem cell differentiation is controlled by manipulating RNA condensates.

1/ Excited to share our new study with @brumbaugh-lab.bsky.social, out in @natbiotech.nature.com! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵 www.nature.com/articles/s41...

Argonautes and small RNAs associated with nematode programmed DNA elimination https://www.biorxiv.org/content/10.1101/2025.10.23.684123v1

Big thanks to all the speakers for their excellent talks: Adelheid Soubry @jamiehackett.bsky.social @nkotaja.bsky.social @romainbarres.bsky.social
@epitep.bsky.social
Anais Vitorino-Carvalho, kaylee Holleman, amrita Raja-ravi-shankar and Blair Schneider from the @colinconine.bsky.social lab

microRNAs blaze into the clinic - Nature Biotechnology After decades-long struggles with microRNA-based therapeutics, Regulus hits paydirt in the clinic and in the marketplace. Is it the beginning of a trend or a one-off?

microRNAs blaze into the clinic www.nature.com/articles/s41...

Nuclear-encoded tRNA genes harbor substantial allelic diversity in three nematode species Cytosolic transfer RNAs, which are encoded as hundreds of genes in eukaryotic nuclear genomes, experience exceptionally high rates of mutation and have been hypothesized to carry significant mutationa...

Did you know that the genes for critical, ancient components of protein synthesis machinery - tRNAs - are bombarded with mutations, leading to remarkable allelic diversity that likely has functional consequences? I didn't until we did this project!
Preprint: www.biorxiv.org/content/10.1...
(1/2)

@pennepigenetics.bsky.social @penngenetics.bsky.social

Stay tuned….

Well-exercised male mice appear to pass fitness to their male offspring Surprising epigenetic effect relies on snippets of RNA packaged within sperm

Male mice that exercise can pass their newly gained fitness on to male offspring.

If the same holds true in humans, researchers say, fathers could help improve the health of any future children by staying in shape themselves. https://scim.ag/47igpZm

A single-cell multiomics roadmap of zebrafish spermatogenesis reveals regulatory principles of male germline formation | Molecular Systems Biology imageimageA multiomics study of zebrafish spermatogenesis integrating scRNA-seq, scATAC-seq, and base-resolution DNA methylomes defines the chromatin and transcriptional states of germ cells, revealing the regulatory dynamics of this continuous ...

www.embopress.org/doi/full/10....

Magnified view of partially methylated domains or highly methylated domains over CpG islands and DNA methylation valleys (DMVs)

The somatic DNA methylation landscape
Figure from our #Review by Zachary D. Smith, Sara Hetzel & Alexander Meissner: DNA methylation in mammalian development and disease go.nature.com/3DlswZn
Free to read here: rdcu.be/dQEND

mRNA initiation and termination are spatially coordinated - PubMed Transcriptional initiation and termination decisions drive messenger RNA (mRNA) isoform diversity but the relationship between them remains poorly understood. By systematically profiling joint usage of...

Hot off the press from the RTI: mRNA initiation and termination are spatially coordinated
buff.ly/vwSuPWC #RNA #RNATherapeutics

RESEARCH PAPER: A noncanonical Pol III-dependent, Microprocessor-independent biogenesis pathway generates a germline-enriched miRNA family
By Sakhawala et al. and Katherine McJunkin

Learn more here:
➡️ https://genesdev.cshlp.org/content/39/19-20/1198.abstract

Sperm sequencing reveals extensive positive selection in the male germline - Nature A combination of whole-genome NanoSeq with deep whole-exome and targeted NanoSeq is used to accurately characterize mutation rates and genes under positive selection in sperm cells.

Now published! Our paper on:
(1) Accurate sequencing of sperm at scale
(2) Positive selection of spermatogenesis driver mutations across the exome
(3) Offspring disease risks from male reproductive aging
[1/n]
www.nature.com/articles/s41...

Our paper on clonal expansions in Sperm is out in Nature www.nature.com/articles/s41...
If you are interested in working at an intersection of Mendelian genomics/Population genetics/Clonal expansions +Cancer genetics/ and of course mutagenesis, please rich out about postdoc in my lab

Generation of modified cows and sheep from spermatid-like haploid embryonic stem cells - Nature Biotechnology Haploid embryonic stem cells for cattle and sheep are produced, opening new reproductive possibilities.

Generation of modified cows and sheep from spermatid-like haploid embryonic stem cells go.nature.com/42wdD05

Protamine lacunae preserve the paternal chromatin landscape in sperm https://www.biorxiv.org/content/10.1101/2025.10.03.680364v1

Check out this new Levine-Lampson collaboration, led by the talented Hyuk-Joon Jeon.

We explored the consequences of inheriting long telomeres from dad and short telomeres from mom. Or the reciprocal. Turns out, parent-of-origin matters (in mice, at least).

authors.elsevier.com/c/1loW-3QW8S...

Do you think it’s actually a miRNA? Any evidence of it loaded into Ago ?

Mouse miR-6236 comes up as very abundant in longer mRNA-seq (polyA and ribo-depletion). Also seems to have homology to rRNA

Goyal Lab

**POSTDOC POSITION** My lab (www.goyallab.org) at Northwestern and CZ Biohub Chicago looking for a postdoctoc in quantitative biology. We work on a range of topics, including single-cell cancer plasticity, modeling single-cell perturbations, theory, and stem-embryo models. contact via email. Pls RT

AWESOME CONFERENCE ALERT!!

I had an absolute blast at the Fusion “Genome Regulation Through RNA” meeting back in 2024, and psyched to see its upcoming return! Let’s geek out about all things Chromatin and RNA together, in Cancun!

Talk abstract deadline: 10/17

Details👇

Transposable elements are vectors of recurrent transgenerational epigenetic inheritance DNA methylation loss at transposable elements (TEs) can affect neighboring genes and be epigenetically inherited in plants, yet the determinants and significance of this additional system of inheritan...

"Transposable elements are vectors of recurrent transgenerational epigenetic inheritance"
Congrats Vincent Colot and team!
www.science.org/doi/10.1126/...

Oligopaint Probe Requests In an effort to make Oligopaint FISH probes more broadly available to the research community, we offer DNA and RNA FISH probe design, synthesis, and generation. By dedicating a full-time staff memb…

We’re excited to share that, after receiving many requests each year from the research community for Oligopaint DNA & RNA FISH probes, we’re piloting a service to design & prepare probes for labs.
Please share with colleagues who may benefit!
ericjoycelab.com/oligopaint-f...

Postdoctoral Scientist- Lim Lab Primary Work Address: Dept of Molecular Biology, Princeton, NJ, 08544 Current HHMI Employees, click here to apply via your Workday account. The Lim Lab at Princeton University is seeking an energetic,...

LIMmunity is growing! 🤰🤱👶

We are looking for curious & driven postdocs to join us at @princetonmolbio.bsky.social & HHMI to explore the fascinating world of maternal-offspring immune partnerships!

Come be part of our collaborative team!

hhmi.wd1.myworkdayjobs.com/en-US/Extern...

Sad to hear that David Baltimore died. I am one of hundreds of scientists that David generously mentored, supported, and inspired. His influence on each of us was deep and lasting, and his impact on the world immeasurable. Arguably David Baltimore is one of the greatest scientists of any generation.

Target RNA recognition drives PIWI^∗ complex assembly for transposon silencing
#Drosophila

An ancient and essential miRNA family controls cellular interaction pathways in C. elegans A microRNA that arose at the origin of eumetazoans regulates cell adhesion and signaling in C. elegans through conserved targets.

Our work on the function of miR-51/miR-100 is out! miR-100 is widely conserved across eumetazoans but its function has been mysterious. Emilio Santillán found in worms it regulates signaling and extracellular matrix genes, some of which seem to be conserved targets! www.science.org/doi/10.1126/...

Just out in press in eLife, a cool and brilliant piece of work by @amywebster.bsky.social: Gene expression variation across genetically identical individuals predicts reproductive traits. elifesciences.org/articles/106...

“Blind obedience to authority is the greatest enemy of truth.”

— Albert Einstein (1879–1955)

Transcription factors SP5 and SP8 drive primary cilia formation in mammalian embryos Although specific transcription factors (TFs) are known to regulate cell fate decisions, the degree to which they can stimulate formation of specific cell organelles is less clear. We used a multiomic...

🤯🤯🤯🤯🤯🤯🤯🤯🤯🤯🤯🤯

Transcription factors SP5 and SP8 drive primary cilia formation in mammalian embryos | Science www.science.org/doi/10.1126/...