Eva Hörmanseder

Reversibility, regulation, and the community of development: the legacy of Sir John B. Gurdon - Nature Communications Nature Communications - Reversibility, regulation, and the community of development: the legacy of Sir John B. Gurdon

We have just published a tribute to John Gurdon, reflecting on his scientific legacy and the profound influence he had on generations of developmental biologists.

The piece is available open access in Nature Communications:
www.nature.com/articles/s41...

Thank you Evan!

Reversibility, regulation, and the community of development: the legacy of Sir John B. Gurdon Nature Communications - Reversibility, regulation, and the community of development: the legacy of Sir John B. Gurdon

We are honored to share our Perspective in Nature Communications, reflecting on the legacy of John B. Gurdon.
Beyond his discoveries, his generosity and curiosity inspired a community of scientists-we remember and celebrate his lasting impact. #JohnGurdon #Xenopus #NatureCommunications

Yearly Lab Luncheon at John’s place. 2017

She Worked in a Harvard Lab to Reverse Aging, Until ICE Jailed Her (Gift Article) President Trump’s immigration crackdown ensnared Kseniia Petrova, a scientist who fled Russia after protesting its invasion of Ukraine. She fears arrest if she is deported there.

The Americans are doing to Kseniia what the Russians did to Brittney Griner for having 0.7 grams of cannabis oil. Except no one is coming to negotiate her freedom and Harvard is sitting on their hands. I am so ashamed. Please share this story.
www.nytimes.com/2025/04/11/s...

#EpigeneticsPodcast with #HelmholtzMunich expert Dr. Eva Hörmanseder, @epihmgu.bsky.social!

🎧 Listen and learn about epigenetic memories & more:
👉 t1p.de/30q54

👉Check out her latest findings on this topic:
t1p.de/43yrw

@epigeneticspod.bsky.social
#Epigenetics #Podcast #Reprogramming #CellFate

In the most recent episode we talked with @evahoermanseder.bsky.social from @www.helmholtz-munich.de‬ about her work on epigenetic mechanisms in cellular memory and gene regulation. #podcast #epigenetics

Listen here: activemotif.com/podcasts-eva...

Russian scientist working at Harvard detained by Ice at Boston airport Kseniia Petrova was returning to the US from a trip to France when officials revoked her visa and detained her

This is very disturbing.
Harvard PhD student Kseniia Petrova (Russian citizen) was arrested by ICE for transporting xenopus embryos into Boston from Paris. She has been detained in Louisiana since Feb. 16.

www.theguardian.com/us-news/2025...

If I could do it all over again, I’d apply here for my postdoc- look at these fantastic opportunities! ⬇️

Reprogramming efficiency varies across cell types in vivo and is modulated by somatic cell identity memory. Eliminating somatic cell transcriptional memory improves reprogramming success #nucleartransfer ow.ly/g1Au50VimTM

@www.helmholtz-munich.de @isscr.org

Fast & Fair peer review A new initiative offering high-quality peer review within 7 working days of submission Biology Open

We’d like to thank our Editors and peer reviewers who made the #fastandfairpeerreview trial possible. Would you like to join our reviewer pool? Visit bit.ly/41N31tO for more details.

Harvard scientist opposed to Ukraine war faces deportation back to Russia: Friends Kseniia Petrova has been in U.S. detention since mid-February after having her visa revoked, according to friends and independent Russian media

Harvard scientist opposed to Ukraine war faces deportation back to Russia: Friends. This sounds like Trump trying to please Putin rather than anything to do with US immigration.
www.independent.co.uk/news/world/a...

Harvard scientist opposed to Ukraine war faces deportation back to Russia: Friends Kseniia Petrova has been in U.S. detention since mid-February after having her visa revoked, according to friends and independent Russian media

Our key collaborator, genius scientist and wonderful person Kseniia is in a horrendous situation right now, see article below. Why? Trump.

Please share, please do not ignore, if you can, help.

www.independent.co.uk/news/world/a...

Thank you very much for this possibility to contribute to this podcast! …but, as it said in my recommendation letter, “she has a tendency to talk fast” :)

Thanks to everyone who contributed to these discoveries discussed here 🙏 Especially to those I forgot to mention cause I was so nervous…

thank you for reposting 🥹

🚨NEW PAPER ALERT!

3 of our teams at IES collaborated to understand why some cells reprogram effectively while others fail
@hamperllab.bsky.social
@antonio-scialdone.bsky.social
@evahoermanseder.bsky.social

Congrats to all the authors of this exceptional paper published @stemcellreports.bsky.social

3D Epigenome Evolution Underlies Divergent Gene Regulatory Programs in Primate Neural Development The expansion of the neocortex is a hallmark of human evolution and is closely linked to neural stem cell biology. Yet, the epigenetic mechanisms driving divergent gene regulation during primate neuro...

🚨New preprint from @bonevlab.bsky.social 🚨: What are the key epigenetic mechanisms that drive species-specific gene regulation during primate neurogenesis - and how do they contribute to the evolution of the human neocortex?
Here’s what we discovered 👇
www.biorxiv.org/content/10.1...

Very happy to share the preprint of my main PhD project in the @bonevlab.bsky.social! Huge thanks to @boyanbonev.bsky.social, all co-authors and members of the @bonevlab.bsky.social! This work wouldn’t have been possible without your contributions!

The last chapter of my PhD is finally out! Huge thanks to my supervisor @genikhovich.bsky.social for supporting “at first glance, stupid ideas” — which turned into a nice paper! That was so much fun!

Thank you Antonio for this great collaboration!

Cell Fate Changes: How Transcriptional Memory Affects Reprogramming

Cell Fate Changes – Transcriptional Memory in Reprogramming

Dr. Eva Hörmanseder, #HelmholtzMunich & team uncovered why some cells resist reprogramming – a key hurdle for regenerative medicine.

👉 t1p.de/43yrw

@epihmgu.bsky.social
#CellReprogramming #Epigenetics #StemCells #RegenerativeMedicine

Tomas and Jonathan spearheaded this joint research project with the @antonio-scialdone.bsky.social lab

Differentiation success of reprogrammed cells is heterogeneous in vivo and modulated by somatic cell identity memory This study investigates how reprogramming success in vivo varies across cell types, revealing that gene expression of the previous somatic cell identity hinders proper differentiation. By following si...

Do you work with reprogrammed cells? Then look at our new paper!

We asked: How well do reprogrammed cells differentiate into complete&functional tissues?

We found that
- some cell types form perfectly but others fail
- reducing levels of one specific TF of the previous lineage can fix problems⬇️

Corrections in single cell migration path in vivo are controlled by pulses in polar Rac1 activation Directed migration of single cells is central to a large number of processes in development and adult life. Corrections to the migration path of cells are often characterized by periodic loss of polar...

A preprint from the lab- Corrections in single cell migration path in vivo are controlled by pulses in polar Rac1 activation.
www.biorxiv.org/content/10.1...

We are hiring.🚨 The Tissue Gene Regulation Lab is looking for an experimental PhD student or PostDoc to join our efforts in devising new single cell methods and decoding gene regulation. 💻🔬🧫
Come join me and my lab in beautiful Copenhagen. 🇩🇰

PhD - lnkd.in/dtKz_gnA
PostDoc - lnkd.in/dBgn6AcK

SAVE THE DATE! The next EMBO | EMBL Symposium on 'DNA replication and genome maintenance: from basic biology to disease' will be held October 20-23, 2026.
 
Organized by Helle Ulrich (IMB), Johannes Walter (Harvard) and Anja Groth (Danish Cancer Institute).

www.embl.org/about/info/c...

🚀 PREPRINT ALERT!

🐸 Research led by our PI @evahoermanseder.bsky.social reveals H3K4 methylation as an epigenetic memory in Xenopus embryos, vital for zygotic genome activation & development.

👏 Congratulations @meghana-oak.bsky.social & rest of authors.

📑 👀 shorturl.at/6MIRn

🔎 #OpenPeerReview

🎆Next #FragileNucleosome meeting is less than a week away! We are delighted to host @manucazottes.bsky.social, @robertadolling1.bsky.social & @leandrosboukas.bsky.social ! We will discuss evolution of XIST regulatory network, cancer epigenetics, and MDEMs!
🗓️ us06web.zoom.us/webinar/regi...

Congratulations Marcel, Manuel and everyone involved!
Wonderful work on transcription replication conflicts, check out highlights below ⬇️

Transcription-replication conflicts drive R-loop-dependent nucleosome eviction and require DOT1L activity for transcription recovery Abstract. Progressing transcription and replication machineries profoundly impact their underlying chromatin template. Consequently, transcription-replicat

I am delighted to share the main work of my PhD project in the @hamperllab.bsky.social now out in @narjournal.bsky.social. TRCs drive R-loop-dependent nucleosome eviction and require DOT1L activity for transcription recovery.
academic.oup.com/nar/article/...

#TRC #r-loop #chromatin

More below 👇