Vicky Lioy

📢 Save the date! #Biophychrom2027 will take place at Paris-Saclay in July 2027. More details coming soon!

Institut Pasteur (@pasteur.fr) is recruiting new young PIs to open new groups in the Institute. Deadline is February 9th! Don't miss the opportunity!

I am very pleased to share that our database of prokaryotic and viral histones, ProHistoneDB, is now available online at prohistonedb.org. Please also see the accompanying article in J Mol Biol: doi.org/10.1016/j.jm...

Bacteria are amazing! The abundant Dps protein binds and protects DNA in stationary-phase cells with minimal effect on chromosome accessibility, dynamics, and organization. Now in NAR doi.org/10.1093/nar/...; I'm really proud of our multidisciplinary team led by Lauren, Lindsay, and Xiaofeng, et al.

Congratulations !

Fresh news on de novo genes! Happy to present our latest work published in Nature communications: www.nature.com/articles/s41...

Keywords not in specific order: intergenic ORFs, de novo genes, GC content, foldability, genetic code, ancestral sequence reconstruction and more :)

Le CNRS met en avant notre article publié dans @natcomms.nature.com
Un grand merci à toutes et tous pour ce beau projet mené en collaboration avec #MKortebi @mickaelbourge.bsky.social @imagerie-gif.bsky.social #NGSFacilityI2BC, #E.vanDijk, @bury-mone.bsky.social, #CDorman et #FBoccard

Creating bacterial genomic diversity through large-scale reconfigurations reveals phenotype robustness to organizational genome change The ability to generate genomic diversity expands opportunities for understanding and engineering biology. Here, we demonstrate on-demand generation of diversity in bacterial genome configurations and...

After 4 years of joint effort of my Lab and Dr. Llorente Team we took for first time SCRaMbLE to a bacterial system! This allowed us to massively reordered the main chromosome of Vibrio natriegens!

biorxiv.org/content/10.6...
Here's a 🧵

SMC and recombination enthusiasts: we updated our work describing the loop extrusion properties of budding yeast condensin and its function in biasing donor usage for mating-type switching. Lots of cool new data, check it out!
www.biorxiv.org/content/10.1...

White start to the year. Happy 2026 to everyone!
@i2bcparissaclay.bsky.social

A new era at the GBD is staring 😉

And all the best to the new direction of the department, @onamy.bsky.social @anne-lopes.bsky.social @daannoordermeerlab.bsky.social. I’m sure many scientific adventures are yet to come!

Today was the last scientific council of #GenomeBiologyi2bc. Thank you @betermieri2bc.bsky.social, #Julie_Soutourina and @phbouloc.bsky.social , for your support and for creating such a great scientific environment.

Nos travaux de recherche mis en avant dans Le Journal du CNRS !😀 @i2bcparissaclay.bsky.social

Open FSEP position in our team 📣
Nous recrutons un/e Ingénieur/e d’étude en biologie.
Profil : être titulaire d’un poste permanent au CNRS (IE) et avoir envie d’étudier la chromatine bactérienne 😉
Date limite : jeudi 15 janvier.
Détails et candidature ici :
mobiliteinterne.cnrs.fr/ords/afip/ow...

What a wonderful week in Japan! 🇯🇵
Many thanks to Kazutoshi Kasho and Prof. Oshima for inviting me to #MBSJ2025.
Special thanks to @naomichitakemata.bsky.social and Shogo Ozaki for organising such a great satellite symposium.
It was truly a pleasure discussing science with all of you.

New exciting work on genome segregation in Haloferax by @premrajka.bsky.social and @bramkamplab.bsky.social group. 🧬<>🧬

Archaeal cells whose DNA has been stained with a blue dye. Zoomed-in images of mutant cells that display chromosome segregation defects.

High-resolution images of DNA-protein complexes obtained with atomic force microscopy. Upon binding, the protein bridges distant sites, forming loops.

📢 Interested in #chromosomes 🧬 & #archaea thriving at the edge of life? PhD project in York,UK on how archaea pass on their genome to daughter cells.Friendly supervisors: me, @steve-quinn-lab.bsky.social & @georgerheath.bsky.social

www.findaphd.com/phds/project...
📅 January 7, 2026
Please RP🙏thx!

IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇

🎉🥳👏Congratulations to Olivier and to the consortium. Excellent results will come to light soon in the #GenomeBiologyI2BC Department.

🚨 Another funded PhD alert🚨

We are recruiting again! For a PhD student to start with us in the @langridgelab.bsky.social October 2026 - please share 👀

If you are interested in foodborne pathogens, public health and phage, look no further 🦠🏥🧬

➡️ tinyurl.com/3zvavp2t ⬅️

Apply by 6 Jan 2026 🗓️

#qed seems to be a new AI tool that could change the way we review (and write!) papers. Let’s try it!

Nucleoid structure and dynamics influence natural chromosomal transformation in Bacillus subtilis: the role of EbfC Abstract. Natural chromosomal transformation (NCT) in Bacillus subtilis requires RecA and its accessory proteins including RecX and RecD2. Inactivation of

Nucleoid structure and dynamics influence natural chromosomal transformation in Bacillus subtilis: the role of EbfC url: academic.oup.com/nar/article/...

Another new team at #GenomeBiologyI2BC. Congratulations @cecilecourret.bsky.social

Kicking off day two at the Spatial Organization of Biological Functions meeting at ICTS Bangalore! The first day was fascinating! #SOBF2025

How do SMC complexes load onto DNA to get ready for loop extrusion?

@roisnehamelinf.bsky.social & co discovered that Wadjet, an SMC complex involved in bacterial DNA immunity, performs some impressive molecular gymnastics 🤸‍♂️🤸‍♂️🤸‍♂️.

Check out the new paper: www.cell.com/molecular-ce...

The recombination frequency (cM/Mb) along chromosome 4 of A. thaliana (female meiosis). In full hybrids (grey), where polymorphism is distributed all along chromosomes, most crossovers occur in the regions surrounding the Centromere (Cen), and very few at chromosome ends (Tel: telomeres). In lines where polymorphism is restricted to chromosome ends (purple), the local recombination rate increases drastically, at the expense of the non-polymorphic regions (yellow).

🚨 First pre-print from my team !!

TL;DR: presence of polymorphism (sequence differences between the homologous chromosomes) can *increase* the local rate of recombination in Arabidopsis thaliana, turning cold regions of the genome hot (purple v. grey) !

Dynamics and interplay of gene expression and chromosome organization across a predatory lifecycle The obligate predatory bacterium Bdellovibrio bacteriovorus alternates between a motile attack phase and a growth phase inside another bacterium, during which it undergoes multiple rounds of DNA repli...

📝New preprint! #MicroSky

🕰️We chart the full, synchronized lifecycle of a predatory bacterium using Hi-C, RNA-seq, ChIP-seq & microscopy.

🧬We uncover dramatic shifts in nucleoid architecture & transcription, tightly coordinated with predation.

www.biorxiv.org/content/10.1...

The @yorkmuseumstrust.bsky.social's Hospitium was such a lovely location for the @biochemsoc.bsky.social #BioPhyChrom2025 conference dinner. Gorgeous gardens, fabulous food & captivating conversations

Thank you to the organisers for creating a great program & friendly interdisciplinary environment

This also happened at #BioPhyChrom2025, congratulations @ceesdekker.bsky.social

@danielabarilla.bsky.social
@damelab.bsky.social
@graingerlab.bsky.social