Maël

Il a le cou tout roux!

merci pour le partage coco ❤️ je fais des gros bisous à ton petit bébé, je suis désolé pour toi encore une fois...
tu connais déjà Pacha... l'animal ever

blocks its ability to infect cells. This innovative approach has successfully neutralized ALL tested SARS-CoV-2 variants and could pave the way for longer-lasting treatments. If further developed, it may even work against other coronaviruses, influenza, AND HIV.

Abstract The ongoing emergence of severe acute respiratory syndrome coronavirus (SARS-CoV-2) variants of concern (VOCs) that reduce the effectiveness of antibody therapeutics necessitates development of next-generation antibody modalities that are resilient to viral evolution. Here, we characterized amino-terminal domain (NTD)- and receptor binding domain (RBD) -specific monoclonal antibodies previously isolated from coronavirus disease 2019 (COVID-19) convalescent donors for their activity against emergent SARS-CoV-2 VOCs. Among these, the NTD-specific antibody C1596 displayed the greatest breadth of binding to VOCs, with cryo-electron microscopy structural analysis revealing recognition of a distinct NTD epitope outside of the site i antigenic supersite. Given C1596's favorable binding profile, we designed a series of bispecific antibodies (bsAbs), termed CoV2-biRNs, that featured both NTD and RBD specificities. Two of the C1596-inclusive bsAbs, CoV2-biRN5 and CoV2-biRN7, retained potent in vitro neutralization activity against all Omicron variants tested, including XBB.1.5, BA.2.86, and JN.1, contrasting the diminished potency of parental antibodies delivered as monotherapies or as a cocktail. Furthermore, prophylactic delivery of CoV2-biRN5 reduced the viral load within the lungs of K18-hACE2 mice after challenge with SARS-CoV-2 XBB.1.5. In conclusion, NTD-RBD bAbs offer promising potential for the design of resilient, next-generation antibody therapeutics against SARS-CoV-2 VOCs.

An illustration of the bispecific antibodies the Stanford-led research team developed to neutralize the virus that causes COVID-19. Named “CoV2-biRN,” these two antibodies work together by attaching to different areas of the virus. Credit: Christopher O. Barnes/Adonis Rubi

The bispecific antibodies target two areas of the virus: One attaches to the “NTD,” or Spike N-terminal domain, an area on the virus that does not change very much. This allows the second antibody to attach to the “RBD,” or receptor-binding domain, essentially preventing the virus from infecting human cells. Credit: Christopher O. Barnes/Adonis Rubio

The study has been published in Science. YES, it is PEER-REVIEWED.
• www.science.org/doi/10.1126/...

THIS IS HUGE! Researchers at Stanford University have developed a dual-antibody treatment that remains effective against ALL SARS-CoV-2 variants by targeting a less-mutable part of the virus. This breakthrough could lead to longer-lasting therapies that OUTPACE viral evolution. 🧪🧵⬇️

gros bébé !!! il est trop mignon

SES POPATTES 🥺🥺

Illustration d'une femme en peignoir allongée sur son trône d'oreillers.

Illustration à la gouache réalisée l'année dernière.

c'est sur la chaîne YTB "Jet Lag : The Game", c'est "tag across Europe" ! il y a une saison terminée et une autre en cours (ça sort le mercredi je crois)

heu attend je vais voir si je retrouve le nom !

mdrr je regardais une série d'un groupe de mecs qui joue au loup à travers l'Europe de l'ouest et ça merdait TOUJOURS à cause du deutsche Bahn 💀

A weather-bent pine tree in a mountain scenario.

And this one deserves its own post, I guess.

We’re open for business!!! 🍄🍄🍄

Shoutout to every senior who doesn't know how to stop the noise coming from their phone rn

Part of the reference sheet i drew for Faux-Kai-Sun
#furry #art

c'est oki.....ils vont grandir 🥺🥺

koeeel les formes de tes p'tits bébés 🥺🥺🥺 je les aime d'amour snif snif

Meme posted by Indigenous peoples movement. The meme shows a picture of a blue big pen and red big lighter on a white background Above the picture it says in black text: the two most stolen items in the world. The big pen has text written next to it saying: Surplus values of workers labor The lighter has written text next to it saying: Indigenous land.

Everyone has imposter syndrome after that guy wasted Shinzo Abe with a thingy

Blue Jay in flight through golden leaves

Blue Jay perched on a white woven arch looking toward the camera

Blue Jays are looking extra special with the golden Fall foliage 😊🪶

Fox: Police shortages reported nationwide amid record-low morale and recruitment

Amazing work everybody, keep it up!!

Small break 🕊️

"trans people in the past were medicinewomen and shamans and seers! revered priestesses!" not me. i'm sitting around carving those little sculptures of the guys with the huge hogs and doing absolutely nothing else to help out around town. everyone in Uruk is entirely sick of my shit

remember when that submersible imploded

Hi everyone!!
I'm Blue (or Kósmos), a French self-taught artist who draws felines most of the time! :]

Here one of my recent work featuring Bluestorm the main character from my universe : Upside-down ✨

dont mind me je vais aller dans tes follows pour me refaire une TL......

say it ain't stoat