Sara Luzzi

Don't miss your chance to register and send your abstract!

Transcription and Chromatin UK is back! This time in Manchester, 17th-19th September. Send your abstract by 17th July for the opportunity to discuss your work with the UK RNA and epigenetics community, and with leading experts from abroad. Click the link below and spread the word!

Beyond the genome: Harnessing the power of super-enhancers for blood cancer - Cancer Research UK - Cancer News The mysteries of the epiregulome need to be tackled head-on if we are to get new precision treatments for blood cancers

Lisa Russell just wrote an insightful article for #CancerNews from @cancerresearchuk.org where she takes us through the promise of super-enhancer biology and what it means for cancer. Read the whole article here:
news.cancerresearchuk.org/2025/05/21/b...

Transcription and Chromatin UK is back for 2025 in Manchester! Make sure you register your interest to be kept in the loop about registration and abstract submission. www.biochemistry.org/events-and-t...

Excited to be at the #ProstateCancerUK #MakingProgress meeting. Loads of great research being showcased today @prostateukprofs.bsky.social @prostatecanceruk.bsky.social

**deadline Mar 30th** Passionate about #cryoEM? Interested in #PhD project on allosteric mechanism of a dynamic enzyme implicated in metabolic and neurological disorders? Join @allostericstate.bsky.social and me in NCL on a funded @mosmedcdt.bsky.social studentship.
www.findaphd.com/phds/project...

The impact of the RNA exosome on ribosome specialisation in different cell types at Newcastle University on FindAPhD.com PhD Project - The impact of the RNA exosome on ribosome specialisation in different cell types at Newcastle University, listed on FindAPhD.com

We have a 4 year PhD position available to study the impact of the RNA exosome on ribosome specialisation! Get in touch if you are interested or just apply. March 31st deadline.

www.findaphd.com/phds/project...

Our Research Theme has joined the platform! Hit follow for updates on our work. 🧬🧫🧪🔬

Cooperative nutrient scavenging is an evolutionary advantage in cancer Nature - Nutrient-starved tumour cells cooperate by secreting aminopeptidases that digest oligopeptides in the microenvironment, creating a shared pool of free amino acids.

First: I apologize for never coming here and now doing so only to brag 😬
Second: I am very proud of the people in our lab. We are a small group in a Bio department and this work took an enormous amount of effort from every one here.
rdcu.be/eaxEz

Nothing in life is to be feared, it is only to be understood. Marie Curie, Physicist and chemist.

Today is International Day of Women & Girls in Science.

Marie Curie, the first woman to win a Nobel Prize. Her contributions have left an indelible mark on the world of science & health & continue to inspire generations of scientists & innovators. 🔬 #WomenInScience #WomenInSTEM

Proteogenomic analysis of evolved aneuploid cell lines & primary tumors reveals cancer adaptive strategies for alleviating aneuploidy consequences – including increased expression of DNA replication & repair factors & of FOXM1 targets
Zuzana Storchova and coworkers
www.embopress.org/doi/full/10....

🚨Thanks to generous support from @cancerresearchuk.org, we have multiple postdoctoral positions available in our lab (www.mardakhehlab.info) @oxfordbiochemistry.bsky.social to study ribosomes synthesis in cancer. Get in touch if you’re interested + RT and spread the word! 📣 #cancer #RNA 🚨

Here is a growing list of conferences and schools in gene regulation for 2025 generegulation.org/conferences-.... You can order/filter this list by the date, deadline, location. Please reply here to suggest new events*

*should be specific to gene regulation

PhD studentship in Prostate Cancer - Refining human prostate tissue culture techniques for better in vivo mimicry and therapeutic insights at Newcastle University on FindAPhD.com PhD Project - PhD studentship in Prostate Cancer - Refining human prostate tissue culture techniques for better in vivo mimicry and therapeutic insights at Newcastle University, listed on FindAPhD.com

PhD Position available in my lab. Interested in prostate cancer research and developing novel disease models to accelerate research impact then this is for you. Come and join of research community @nucancer.bsky.social
www.findaphd.com/phds/project...

Do you know where transcription of a gene actually stops? Hint: it is not the annotated gene end.
In our new paper in Nucleic Acids Research we argue that phosphorylation on threonine 4 of RNA Pol II CTD is a marker of transcription termination in animals... 🧵
academic.oup.com/nar/advance-...

Pol II degradation activates cell death independently from the loss of transcription Pol II-mediated transcription is essential for eukaryotic life. While loss of transcription is thought to be universally lethal, the associated mechanisms promoting cell death are not yet known. Here,...

We just posted a preprint about a death mechanism that we find truly surprising.

When you turn off transcription, cells die (duh!)... but did you know this happens due to loss of Pol II itself, not loss of Pol II activity!?!

preprint here and a thread (1/n): www.biorxiv.org/content/10.1...
🧪

Ever wondered how transcription choreographs histone modifications? Our work reveals the basis of co-transcriptional H3K36me3 by SETD2. We visualize how a histone writer coordinates with the transcription machinery! This is the magnus opus of @jonmarkert.bsky.social!
tinyurl.com/setd2

An Atypical Mechanism of SUMOylation of Neurofibromin SecPH Domain Provides New Insights into SUMOylation Site Selection Neurofibromin (Nf1) is a giant multidomain protein encoded by the tumour-suppressor gene NF1. NF1 is mutated in a common genetic disease, neurofibroma…

Beware using FLAG tags in SUMOylation studies, as the lysines in the DYKDDDDK sequence can be SUMOylated according to this report... www.sciencedirect.com/science/arti...

Interested in RNA biology, cancer or vascular research? I have a position open for either a research assistant or a new postdoc to start expanding the fast-growing research area of cardio-oncology! Apply here: jobs.ncl.ac.uk/job/Newcastl...
Happy to have informal chats! Please share 🧬.

Can anyone recommend a service provider offering nanopore direct RNA-seq? Looking for reasonable pricing and turnaround time; ideally based in UK or Europe.
#RNA #RNAseq #ONT #RNAsky

Elucidating the Mechanism of Hypoxic Reprogramming of the Estrogen Response. at University of York on FindAPhD.com PhD Project - Elucidating the Mechanism of Hypoxic Reprogramming of the Estrogen Response. at University of York, listed on FindAPhD.com

Are you looking for PhD studentship? We're advertising a fully funded PhD project, get in touch if you're interested.

The project focuses the effects of hypoxia in tumours on the oestrogen response in breast cancer.

Details: www.findaphd.com/phds/project...

#PhDLife #BCMS 🧪 Please Share.

Search for Postgraduate Scholarships and Other Funding We know that how you fund your postgraduate studies is very important. Our funding database gets you to the information you need quickly.

First post on Bluesky! I have been awarded a @thebhf.bsky.social 3 year #PhD Studentship so looking for enthusiastic people to apply who are interested in researching the #genetics of #cardiovascular development @newcastleuni.bsky.social. Apply here: tinyurl.com/yc6paa5w

That's awesome Dan! Congratulations 🎉

If you're here to reconnect with Nuclear Receptor biologists, I made a go at a starter pack of who I've found.

If you want to be added or if you have suggestions of wonderful people I've missed - let me know.

You're also welcome to follow me for StarTrek gifs and scicomm.

🧪

go.bsky.app/UeBP3kx

🙋🏼‍♀️ please - AR stuff going on here, but interested in others as well.

#RNA researchers and afficionados: New to Bluesky or been here for a while?
Check my #RNAsky starting pack and feel free to ask me to add you to the list. Or share with us your RNA starter pack ! 🧪
go.bsky.app/RN6HnZp

First post on this platform with some exciting news: I'll be starting a position as Faculty Fellow here in Newcastle in January 2025! The lab will be studying #transcription and #RNA processing in #cardiooncology. More updates to come in the next few months so watch this space! 🦋