James Nolan

Excited to share our new paper out today in @cp-molcell.bsky.social! We show that the H3K27M oncohistone rewires cPRC1, creating a unique dependency on CBX4/PCGF4-containing complexes, and also reveal a previously unknown function of CBX4. Highlights below (1/11).

21.05.2025 16:12 — 👍 23    🔁 10    💬 5    📌 2

Our work identifying CBX4 as a potential therapeutic target for diffuse midline glioma has just been published in Molecular Cell! Check out co-first author @eimearlagan.bsky.social’s overview below.

21.05.2025 21:25 — 👍 7    🔁 1    💬 0    📌 0

🧵 1/ We’re excited to share that our new paper with @adrianbracken.bsky.social lab is out 🎉 In this study (which began over 10 years ago!), we explore the biology of PRC2 and PRC1 in non-dividing cells. We also explore the effects of PRC2 inhibitor drugs on these cells. Here’s what we found👇

14.01.2025 22:57 — 👍 41    🔁 19    💬 3    📌 2

Congrats to @jamesnolan.bsky.social (now at @pmresearch-uhn.bsky.social) on his #ASH24 abstract achievement award for his PhD research @tcddublin.bsky.social! @adrianbracken.bsky.social 🇮🇪🇨🇦 @ash-hematology.bsky.social #Lmsm #ASHKudos

10.12.2024 17:49 — 👍 19    🔁 1    💬 1    📌 0

Looking forward to sharing collaborative work by myself and @dr-chromatin.bsky.social from the labs of @adrianbracken.bsky.social and @conwayer1.bsky.social at #ASH24 in San Diego this week. #hemesky #lymsm please feel free to stop by and share your thoughts.

05.12.2024 19:04 — 👍 17    🔁 2    💬 0    📌 0

I too aspire to this 😂

02.12.2024 01:33 — 👍 1    🔁 0    💬 1    📌 0

Count me in please :)

25.11.2024 20:59 — 👍 2    🔁 0    💬 0    📌 0

🎉📢 Delighted to share our work from Princess Margaret Cancer Centre 🙌🏼

PTCy-based GvHD prophylaxis was associated with an improved GRFS, NRM, and OS 💪🏼

A big shout-out to @haemophage.bsky.social for his mentorship 🙌🏼

doi.org/10.1182/bloo...

#MedSky #HemeSky

21.11.2024 16:38 — 👍 38    🔁 11    💬 4    📌 2

ScienceDirect.com | Science, health and medical journals, full text articles and books.

How does PRC1 counteract transcription?

See this preview from @adrianbracken.bsky.social and I on an exciting new study from @robklose.bsky.social lab where they show ncPRC1 blocks the early stages of transcription.

www.sciencedirect.com/science/arti...

@conwayer1.bsky.social for title inspo!

20.11.2024 23:19 — 👍 32    🔁 13    💬 1    📌 2

My colleague @fergutierrezro1 giving an excellent talk at #ESHBMFS2024 on the clinical implications of clonal hematopoiesis in #telomere biology disorders 🧬; dependent on specific mutation with U2AF1, TP53, and chr1+ associated with #MDSsm and #AMLsm.

16.11.2024 13:28 — 👍 6    🔁 2    💬 0    📌 0