Intracellular Ion Channel Laboratory (Singh lab)

Delighted to share our recent article published in @pnas.org!
Provided insights into the shape of the lncRNA RMRP & identified two motors — DDX5 and DDX3X — that help it reach the mitochondria. Without them, RMRP is trapped in the nucleus, disrupting mitochondrial genes.
www.pnas.org/doi/10.1073/...

CLICs are important. Just published as a part of our excellent collaboration.

@popstarlab.bsky.social at FASEB

How many anion channels are present in mitochondrial associated membranes? Check out here

www.cell.com/biophysj/ful...

Undergrads (Denis and Mayukha) performed initial experiments, and manuscript was shaped by Shridhar and Satish (postdocs)
@BiophysJ

Indels allow antiviral proteins to evolve functional novelty inaccessible by missense mutations Tenthorey et al. compare the effects of missense and indel mutations on the acquisition of functional novelty by the rapidly evolving antiviral protein TRIM5α. They find that single indel mutations al...

Proud of this work, led by the amazing Jeannette Tenthorey (now Assistant Professor at UCSF), demonstrating the adaptive power of single indel mutations in host-virus arms races, but a little sad that this is the coda to her amazing postdoc in the Malik & Emerman labs.

www.cell.com/cell-genomic...

Sodium or Potassium, and Chloride or Bicarbonate: Which Combination is Worth Its Salt? Ragavendra R Baliga, Harpreet Singh, Jagat Narula; Sodium or Potassium, and Chloride or Bicarbonate: Which Combination is Worth Its Salt?, European Journal

Pick your fav ion. Editorial with @rrbaliga.bsky.social and Narula labs. academic.oup.com/eurjpc/artic...

Molecular principles of redox-coupled sodium pumping of the ancient Rnf machinery | Nature Communications
#ionchannels

www.nature.com/articles/s41...

Welcome! You are invited to join a webinar: Careers Beyond the Bench: Moving to a World Outside the Lab. After registering, you will receive a confirmation email about joining the webinar. Have you started thinking about your next career step? Are you wondering if you can apply your academic skills in industry? Or what skills outside of academia you may bring to the lab? Join us to…

Have you started thinking about your next career step? Join us for Careers Beyond the Bench: Moving to a World Outside the Lab to explore career options in consulting, industry, and academia

March 25, 2 PM Eastern

Welcome! You are invited to join a meeting: Women in Biophysics: Journeys and Challenges. After registering, you will receive a confirmation email about joining the meeting. Join us for an inspiring event: “Women in Biophysics: Journeys and Challenges”! Four prominent women biophysicists, representing diverse career paths from the biotech industry to academia, will share…

Join us March 24 for an inspiring event: “Women in Biophysics: Journeys and Challenges”! Four prominent women biophysicists, representing diverse career paths from the biotech industry to academia, will share their experiences navigating the field. buff.ly/uQY2gL2
#BiophysicsWeek

Functional large-conductance calcium and voltage-gated potassium #ionchannels in extracellular vesicles act as gatekeepers of structural and functional integrity | Nature Communications #openaccess https://buff.ly/3PmJ5qx

@jgp.org exciting call ..

Extracellular vesicles contain ion channels that make cell-to-cell cargo transport possible Scientists have revealed the secret to the structural integrity of tiny particles that transport cargo from cell to cell through blood vessels and bodily fluids: special proteins that keep their membranes intact as they negotiate shifting electrical impulses in different biological environments.

Extracellular vesicles utilize ion channels to maintain membrane integrity and effectively transport cargo between cells, potentially enhancing their use in therapeutic applications. doi.org/g8z3mc

BMM subgroup at the 2025 Biophysical Society Meeting.

Functional large-conductance calcium and voltage-gated potassium channels in extracellular vesicles act as gatekeepers of structural and functional integrity - Nature Communications Extracellular vesicles secreted by cells play a crucial role in cellular communication. Here, the authors identify a functional BK channel in extracellular vesicle membranes and establish its role in ...

Catch our recent study on BK channels in extracellular vesicles @naturecomms.bsky.social funded by NHLBI. The manuscript reports the functional BK channel in EVs and its role in regulation of EV integrity. EV BK provides protection from IR injury. #extracellularvesicle
www.nature.com/articles/s41...

Gururaja Rao, S., Lam, A., Seeley, S., Park, J., Aruva, S., Singh, H. (2024). . The BK(Ca) (slo) channel regulates the cardiac function of #Drosophila. Physiological reports, 12(7):e15996 physoc.onlinelibrary.wiley.com/doi/10.14814...