Clément Brunner

Bold Science
Real impact
Welcome to VIB-KU Leuven Center for Neuroscience !
Exciting time 🤩

Continuous monitoring of cerebrovascular autoregulation using functional ultrasound imaging in the piglet brain. https://www.biorxiv.org/content/10.1101/2025.09.09.675065v1

Kudos to Théo Lambert and the Urban Lab @openfus.bsky.social

Thanks to
@nerflabs.bsky.social
@cbdresearch.bsky.social
@viblifesciences.bsky.social
@leuvenbrainins.bsky.social
@fwovlaanderen.bsky.social
for the support and trust !

PyfUS is part of the @openfus.bsky.social , driving adoption of fUS tech via cutting-edge tools for data acquisition & analysis.

🔗Software: github.com/OpenfUS/PyfUS
📚Docs: pyfus.readthedocs.io/en/latest/
🧪Data: doi.org/10.5281/zeno...
🌐 openfusi.com

#OpenNeuro #OpenSource

Built with flexibility in mind, PyfUS supports:
1⃣ Linear & matrix array transducers
2⃣ Atlas-based or atlas-free modes
3⃣ Easy user-designed extensions

👊Once you try it, you'll never go back.

PyfUS provides an end-to-end pipeline for fUS data: from registration & signal processing to data-viz.
✅Region-based averaging (400+ regions)
✅Correlation analysis
🔥 Plus: single-voxel clustering for fine spatiotemporal insight at the voxel level.
#neuroimaging #fUS #BrainData

We map brain-wide functions of awake mice at the single-voxel scale !

Introducing PyfUS our brand new, ground-setting, open-source software for analysing brain-wide functional ultrasound imaging datasets.

Now in #Neurocomputing
@sciencedirect.bsky.social

doi.org/10.1016/j.ne...

New research from the @farrowlab.bsky.social and @boninlab.bsky.social at NERF out in @currentbiology.bsky.social reveals how the intricate dendritic architecture of midbrain neurons helps detect and compute critical motion cues.
https://authors.elsevier.com/sd/article/S0960-9822(25)00820-6

New paper in Imaging Neuroscience by Théo Lambert, Alan Urban, et al:

Functional ultrasound imaging and neuronal activity: How accurate is the spatiotemporal match?

doi.org/10.1162/IMAG...

From our study, fUS can be seen as a robust estimator of local spiking as both signals are linearly correlated with minimal spatial spread.

Changes in fUS amplitude, shape, or extent have proportional counterparts in spike rate.

Congratulations to the team 🥳

🚨New from Urban Lab @openfus.bsky.social
in @imagingneurosci.bsky.social

We combined fUS & Neuropixels in awake mice to test how well fUS reflects neuronal spiking. We targeted 3 visual regions during stimulus-evoked activity.

How reliable is fUS vs spikes?

doi.org/10.1162/IMAG...

🎨 Painted faces
🐁 Tickling experiments
🙋🏻‍♀️ Thought-provoking questions

Where else but at the NERF retreat? 🤩

The anterior olfactory nucleus mediates curious exploration evoked by novel odors https://www.biorxiv.org/content/10.1101/2025.05.19.654779v1

Exciting news: @boninlab.bsky.social‬ & @vanderhaeghenp2.bsky.social with ‪@franckp.bsky.social‬ receive SFARI funding to study how early synaptic development in SYNGAP1 mutants shapes brain circuits & behavior in autism. 👏
https://tinyurl.com/54ywzxm9

Ambient Light Impacts Innate Behaviors of New-World and Old-World Mice Animals encounter predators and prey under diverse lighting conditions that signal different risks and opportunities, yet how ambient illumination shapes innate approach and avoidance behaviors remain...

New paper on bioRxiv: "Ambient Light Impacts Innate Behaviors of New-World and Old-World Mice" - together with @farrowlab.bsky.social, with data from NERF master students and two of my lab members! A study across 3 species: Mus musculus, Peromyscus maniculatus & P. polionotus doi.org/10.1101/2025...

👋Hello BlueSky!🧠
👇Below is a thread on Open Neuroscience and how to contribute to our website:
🔬Know a #openscience #neuroscience project?
✍️Please list it on open-neuroscience.com -> forms.office.com/e/5QtUtMc3hw
🔍We will do a brief spam check and upload it to the website!
1/n

📣 Scientists led by Sandrine Da Cruz have successfully seeded the accumulation of TDP-43—a hallmark of ALS and frontotemporal dementia—using lab-engineered protein fragments 🧠🔬 Find out more 👉 cbd.sites.vib.be/en/news#/new...

News from Urban lab @cbdresearch.bsky.social

Thus new review by Jennifer Hoy (University of Nevada) and Karl Farrow (NERF) takes a deep dive into the role of the superior colliculus.
https://www.cell.com/current-biology/fulltext/S0960-9822(25)00052-1

Beautifully illustrated by Pia Rachedi + open access

@farrowlab.bsky.social

New work co-led by @ppjgoncalves.bsky.social introduces a powerful new approach to model conditional distributions of neural and behavioral data using masked variational autoencoders.
Congratulations to @auschulz.bsky.social‬ et al.
https://www.cell.com/cell-reports/fulltext/S2211-1247(25)00109-3

openRxiv has arrived!

We’re thrilled to announce the launch of openRxiv as an independent, researcher-led nonprofit to oversee bioRxiv and medRxiv, the world’s leading preprint servers for life and health sciences.
openrxiv.org/introducing-...

#openRxiv #OpenScience #Preprints #bioRxiv #medRxiv

Aix Marseille university's "Safe Place for Science" program will provide 10 to 15 million euros ($11 to 16 million) that can accommodate around 15 researchers over three years. phys.org/news/2025-03...

Criminalizing protest is a hallmark of authoritarian regimes

🚨Exciting update🚨
We’ve recently expanded this method to whole-brain single-voxel clustering. Stay tuned for more breakthroughs as we push the limits of high-quality and high-resolution brain imaging with fUS! 🚀🧠✨

GitHub - OpenfUS/PyfUS Contribute to OpenfUS/PyfUS development by creating an account on GitHub.

The PyfUS software used and described in the paper is available online at github.com/OpenfUS/PyfUS

Congratulations to Dr Théo Lambert and all the Urban Lab team 🤩
@nerflabs.bsky.social
@cbdresearch.bsky.social
@viblifesciences.bsky.social

Single-voxel clustering expands the fUS signal analysis toolbox! It enables paradigm-free analysis in behaving subjects, atlas-free investigations, and even brain decoding—unlocking new possibilities in neuroimaging 🧠💡

Our work explores the strengths and limitations of each method, offering insights into the trade-offs between dimensionality and comprehensiveness. A must-read for anyone working with fUS signal analysis! 📊🔍

We compared single-voxel clustering with conventional region-averaging and correlation maps to assess their accuracy in capturing contrast modulation effects on hemodynamic responses. How does our approach stack up? Keep reading! 👇

Spatiotemporal Clustering of Functional Ultrasound Signals at the Single-Voxel Level Functional ultrasound (fUS) imaging is a well-established neuroimaging technology that offers high spatiotemporal resolution and a large field of view. Typical strategies for analysing fUS data compri...

🚀New from Urban Lab in #eNeuro @sfnjournals.bsky.social We used spatiotemporal clustering of single fUS voxels to map visual activity in awake mice. This high-resolution method precisely separates signals, revealing fine-grained activity patterns like never before🧠✨ tinyurl.com/47t27c7k

Detection, extraction and skeletonization of 🐭🧠 vessels from brain-wide angiograms acquired using fUS.

🎥 of the procedure : tinyurl.com/bdh46v6f