Michelle Linterman

Fantastic to have Johanne Jacobsen at @malaghan.bsky.social this week presenting her beautiful work on germinal centre T cells, in all their complexity.

Finally, after moving halfway across the world to beautiful Aotearoa New Zealand, our (Italian) espresso machine has arrived. Even better that we can get tasty beans from Acme who also make a special @malaghan.bsky.social blend that supports our research ❤️ lnkd.in/gbWi6RuW

Not in our contribution, simply because it's not our area of expertise. But it's a really important topic.

Aging's impact on the immune system Description This 2025 collection of The Journal of Immunology features a special collection of articles curated by guest editor Patricia Gearhart. The collecti

Great to have the @jimmunol.bsky.social special collection, “Aging's impact on the immune system” out. academic.oup.com/jimmunol/pag...

Thanks for highlighting our work 🙏 Credit to @wsfoster.bsky.social and Edith Marcial Juárez for leading on this.

Highlights of 2024: unleashing the power of NK cells—cancer's worst nightmare
onlinelibrary.wiley.com/doi/10.1111/...

Adaptive immunity in barrier tissues Immune responses lie at the heart of almost every aspect of human health, including host responses to infection, autoimmunity, cancer, metabolism and aging. While adaptive immune responses by B and T…

🚨🦠🔬 Last month to register to the EMBO workshop on Adaptive Immunity in Barrier Tissues.

📍 Where: Basel, Switzerland
📅 When: 26th–29th August 2025
📝 Registration deadline: 30th May 2025

Childcare support & travel grants from @embo.org and @efis-immunology.bsky.social

#EMBOBarrierTissues

<em>Immunology & Cell Biology</em> | ASI Journal | Wiley Online Library In this article for the Highlights of 2024 series, we review the latest advances in the biology of the germinal center response. These discoveries provide key insights into germinal center function a...

Our @immunolcellbiol.bsky.social "Highlights of 2024: Germinal Centers" is now out. Led by Theresa Pankhurst, we discuss some (there's never enough space for all!) neat germinal centre papers that were published in 2024, and whose findings are moving the field forward. doi.org/10.1111/imcb...

Can't wait! I'm really looking forward to this meeting, so many amazing talks. Thanks @maurogaya.bsky.social @immunologyking.bsky.social @embo.org for organising ❤️ #EMBOBarrierTissues

Ectopic germinal centers in the nasal turbinates contribute to B cell immunity to intranasal viral infection and vaccination | PNAS The nasal mucosa is the first immunologically active site that respiratory viruses encounter and establishing immunity at the initial point of path...

Neat @pnas.org paper from @angelettilab.bsky.social & @matsbemark.bsky.social on ectopic germinal centres in the nasal turbinates of mice and humans. doi.org/10.1073/pnas...

Thank you for the @thelisterinstitute.bsky.social support for this project! We couldn't have done it without you.

Thanks Danika!

Thanks for highlighting our paper and tagging the wonderful scientists (who are on blue sky) who did the work ❤️

Lung B cells in ectopic germinal centers undergo affinity maturation
www.pnas.org/doi/10.1073/...
@linterman.bsky.social
@smguillaume.bsky.social
@wsfoster.bsky.social
@sanmarti92.bsky.social
@emae-watson.bsky.social

Such a pleasure to work with you ❤️

You're right! They do!

Thanks Nate!

Thanks Ziv!

From analysis of clones from the lung and the lymph node, it was clear that lung B cells may directly seed local lung memory B cell responses, which @smguillaume.bsky.social was able to show in vivo by blocking lymphocyte egress from lymph nodes with FTY720.

@smguillaume.bsky.social and Grant Kennedy worked together to show that lung germinal centre B cells are largely clonally distinct from those in lymph nodes.

@smguillaume.bsky.social used single cell sequencing to show that after NP-KLH/house dust mite treatment, lung germinal centre B cells were able to acquire high affinity B cells, although this was not as fast as in the lymph node germinal centres.

Lung germinal centres are smaller and less densely packed with cells that those in lymph nodes, but despite this @sanmarti92.bsky.social @smguillaume.bsky.social and @wsfoster.bsky.social were able to show they still showed light and dark zone polarisation.

Lung B cells in ectopic germinal centers undergo affinity maturation | PNAS The lungs are constantly exposed to the external environment and a myriad of antigenic challenges within the air. Chronic exposure to allergens and...

Great to have our paper out in @pnas.org showing that lung B cells in ectopic germinal centers undergo affinity maturation.

@smguillaume.bsky.social @wsfoster.bsky.social @sanmarti92.bsky.social @emae-watson.bsky.social Silvia Innocentin, Grant Kennedy & Alice Denton. doi.org/10.1073/pnas...

Thanks to @zanivanlab.bsky.social , Max Mazzone and the Forbeck Research Foundation for a fantastic Forum on Harnessing stroma immune interactions for anti-cancer therapy. I learnt a huge amount from the participants and all the discussion.
www.forbeckforums.org/forums/harne...

Thank you 🙏

Great to have our latest review "The cellular factors that impair the germinal center in advanced age" out @jimmunol.bsky.social.

Work led by @wsfoster.bsky.social and Edith Marcial-Juárez. With @sanmarti92.bsky.social creating the beautiful GC images in figure 2.

doi.org/10.1093/jimm...

Thanks for highlighting our work. Credit goes to @wsfoster.bsky.social and Edith Marcial-Juárez for bringing this together

Thanks for the shout out. Credit to William Foster and Edith Marcial-Juárez for leading on this review.

<em>Immunology & Cell Biology</em> | ASI Journal | Wiley Online Library In this manuscript for the “Highlights of 2024” series, this is me trying to summarize recent discoveries regarding the emerging regulatory and effector roles of γδ T cells during sepsis, both in hum....

Are you ready for it?

"Highlights of 2024: γδ T cells and bad blood"

A summary of the emerging regulatory and effector roles of #gdTcells in #sepsis.

And it may also contain a few Taylor Swift references. More than 50 in fact.

Thank you so much @immunolcellbiol.bsky.social for playing along!

Sustained innate interferon is an essential inducer of tertiary lymphoid structures Calvanese et al. discovered that type I interferon is an essential upstream mediator for the development of tertiary lymphoid structures in the lungs. IFNAR1 signaling results in the production of LT....

Really nice @eurjimmunol.bsky.social paper from Karina Silina & @marieszh.bsky.social labs on the IFN-Lymphotoxin-Cxcl13 axis in forming tertiary lymphoid structures in the lung doi.org/10.1002/eji....