Julie Carnesecchi

#Drosophila #FlyCROSS 2025-26 updates -
84 mentor-mentee matches were made ✅
Out of which 90 % of mentees were matched to one of their preferred mentors.
Keep and eye for the future program notifications. See you all at #Dros26
Below are the mentee demographics and response summary.
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Had a great time with my #drosophila #JEDI fellows Adam Dobson and @nathanwoodling.bsky.social. Thanks so much Adam for the invitation: exciting science, insightful EDI discussions and great colleagues at the School of Molecular Biosciences in Glasgow! A rainy but so friendly scottish spirit 😊

A small polymerase ribozyme that can synthesize itself and its complementary strand The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...

How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller?

Excited to share our latest work in @science.org on a new small polymerase.
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The registration is open! Junior #Drosophila PIs, join us for inspiring scientific discussion, contribute a talk and listen to our keynote speaker, Eugenia Chiappe. We meet in Palmela, Portugal from June 1st to 3rd. Register soon as spots are limited!

congressos.mundiconvenius.pt/geral/inseri...

Thank you Zayna 🤗. Mouse, fly and RNA, altogether 😁

Looking forward to this exiting collaboration with @clembrnrd.bsky.social on RNA biology! can't wait to meet in London, Exeter and in our @igmm-montpel.bsky.social
Manu thanks to the British Council for their support.

Enjoy 🤩

Chiappe Lab Sensorimotor Integration Lab

Registration will open soon for the next JEDI meeting: June 1st - 3rd in Palmela, Portugal! Join us and our keynote speaker Eugenia Chiappe. Her #neuroscience lab studies how #Drosophila estimates its own movement and integrates sensory inputs to control locomotion.
chiappelab.org

I am very happy (and a bit scared) to present to you what we have been working on over the last 4 years. This manuscript is exactly what I dreamt of when I started the lab and I could not be happier and prouder of the outcome!

Dear #Drosophila researchers, the year starts with good news! The date and venue for our next meeting is confirmed: June 1st to 3rd at the beautiful Historic Hotel Castle De Palmela in Portugal! Mark the dates, registration will open soon!

The commitments in the SAFE Labs Handbook.

A new community-driven lab handbook for reducing conflict and creating more positive and equitable work environments gets strong support from a survey of 200 researchers.
buff.ly/K7CGFLV

@florage.bsky.social

@cnrsoccitanieest.bsky.social @biolum-montpellier.bsky.social

Yesterday at @igmm-montpel.bsky.social we sold cakes &crêpes for @afm-telethon.bsky.social, all cooked and sold by volunteers. Proud to support research on neuromuscular disease, fundamental myology & gene therapy. Thanks, Florence Rage and everyone who contributed or came by! #Solidarity #Research

Systematic analysis of noncanonical ribosomal protein paralogs does not provide evidence for specialized functions in Drosophila

So excited to finally be able to share my first paper and the culmination of my PhD work with @felipekteixeira.bsky.social 🪰🔬

www.pnas.org/doi/10.1073/...

Congrats!!

When setting goals, we often focus on achieving milestones like a PhD, job, tenure, or promotion. Those are great goals but they’re not enough.

We also need to think about:
-Why we’re pursuing that goal
-What specifically we need to do to succeed
-The values we will follow as we do the work

RNA and Proteins: Who Bosses Whom?

Despair seems like a reasonable course of action
'Some estimates are that up to 20% of the entire proteome can bind RNA and moreover that about 20% of all known protein complexes have an RNA component in them and you really have to think about how to deal with such large figures.'

A reminder that the abundance of 'housekeeping' proteins varies significantly across cells and tissues.

GAPDH is often slandered as a 'housekeeping' protein, and its abundance varies significantly across human tissues.

How do you define a 'housekeeping' protein ?

Congrats @longweibai.bsky.social and al 🥳🥳

Hi folks,

Check out our updated website!
Details on next year's conference will be posted there soon!

fly-jedi.org

Cold induced #RNA binding protein linked with longevity and DNA repair

Excited to share my first PhD student’s @biorxivpreprint.bsky.social!

Tracking 5 dyes simultaneously Kavan Gor @embl.org tracks nascent #RNA folding during #ribosome assembly to correlate structural with functional information on single RNA molecules!

Check it out!

www.biorxiv.org/content/10.1...

AI-generated image of a lightsaber-wielding figure conquering Portugal.

Preparations for the next JEDI meeting are underway! The upcoming Junior European #Drosophila Investigator / #NewPI meeting is planned for Portugal in June. Final dates and additional details will be announced soon - stay tuned for updates!​

Two individually marked bumble bees are shown in a tunnel used for affective contagion experiments.

This week in Science, researchers demonstrate positive affective contagion—a core component of empathy—in bumble bees.

The discovery shows that even insects can share affective states, tracing the roots of affect and social cognition deep into evolution. Learn more: https://scim.ag/4oblMQq

Principles of protein abundance regulation across single cells in a mammalian tissue Protein synthesis and clearance are major regulatory steps of gene expression, but their in vivo regulatory roles across the cells comprising complex tissues remains unexplored. Here, we systematicall...

This article is a homecoming for me.

As a PhD student, I focused on the growth-rate transcriptional regulation in yeast.

Now, ~ 20 years later, we report protein regulation scaling with the growth rates of single cells in mammalian tissues.

www.biorxiv.org/content/10.1...

A new family of ribosome hibernation factors in Archaea Ribosome hibernation preserves translation machinery during stress, yet its mechanisms in Archaea remain poorly defined. Here we identify Hib, a previously unrecognized family of archaeal hibernation factors. Genetic, structural and biochemical analyses show that Hib binds ribosomal subunits, blocking the mRNA channel and tRNA sites to inactivate translation. Deletion of hib in Thermococcus barophilus delays recovery from stationary phase and reduces 70S ribosome pools, establishing its role in ribosome preservation. Hib displays a unique modular architecture, combining a bacterial-like HPF module with tandem CBS domains. Cryo-EM structures reveal conformational heterogeneity of Hib:ribosome complexes, consistent with dynamic engagement, and the CBS-containing N-terminal domain binds adenine nucleotides, suggesting a link between hibernation and energy status. These findings define Hib as a key archaeal hibernation factor and provide a framework for understanding ribosome dormancy and adaptation across all domains of life. ### Competing Interest Statement The authors have declared no competing interest. Agence Nationale de la Recherche, https://ror.org/00rbzpz17, ANR-25-CE12-4161

A new family of ribosome hibernation factors in Archaea | bioRxiv https://www.biorxiv.org/content/10.1101/2025.10.11.676729v1?rss=1

M2 interdisciplinary internship RNA, Hox, Evo-Devo | Julie Carnesecchi Funded #M2 #Internship (6 months) — Montpellier | IGMM × ISEM We are recruiting a motivated M2 student to join a joint project on Hox factors beyond DNA, testing how RNA binding by conserved transcri...

@igmm-montpel.bsky.social @isemevol.bsky.social @umontpellier.bsky.social
www.linkedin.com/posts/julie-...

M2 internship (funded, 6months) in Montpellier — IGMM × ISEM with amazing @aigverte.bsky.social
Project: Hox factors beyond DNA: how RNA binding links molecules to body-plan evolution.
Start: early 2026
Apply: CV+motivation
#Master2 #Internship #Montpellier #RNA #Hox #EvoDevo #Drosophila #Bat

Figure from the preprint showing sensory neuron morphology with different levels of Cas9 expression.

High levels of Cas9 are toxic in sensory neurons. Reducing Cas9 levels with uORFs avoids toxicity and is compatible with efficient editing. From @thompsonpeerlab.bsky.social. Fly lines @vdrc-flies.bsky.social

#CRISPR #Drosophila

www.biorxiv.org/content/10.1...