Max Tauc-Adrian

Took me a moment to find them! Looks quite interesting! Surprised by the 512px stack size but reasonable resolution for cellular assays

ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS 🧬🎨🍬

The glycocalyx, our cells' sugar coat, holds secrets in immunology, cancer, viral infections, and more. Visualizing its molecular architecture was impossible… until now. #glycotime #microscopy

www.biorxiv.org/content/10.1...

Save the date !
Frontiers in Neurophotonics Symposium 2025 in Bordeaux
October 6-9
frontiersneurophotonics.org/2025-speakers/
🧪

only took me 4 hours this time to get all dependencies sorted out to run #cellpose in #cellprofiler. Documentation is great for both, but every system I install this on has it's own set of problems to get started. sigh.

Non-canonical CDK6 activity promotes cilia disassembly by suppressing axoneme polyglutamylation Polyglutamylation, a major posttranslational modification of tubulin on the axoneme, is crucial for the signaling functions and stability of primary cilia.

Cool to see another example of non-conventional/mitotic CDK (6) activity on #microtubules: doi.org/10.1083/jcb.... . We found a role for CDK1 changing microtubule dynamics during microglial activation and I was curious to see if there are more cases like this!

We just released and uploaded a new version of *Mastodon*, the large-scale tracking and track-editing framework for large, multi-view images.

Mastodon is available via Fiji, via a dedicated update site.
mastodon.readthedocs.io/en/latest/do...

Below is a thread that survey some of the novelties ⏬️

I was thinking about the Mizar Tilt lightsheet today. There was quite a buzz when it was released but I haven't heard much about it since. Do people like it?

🧵Prepint alert! Optimizing Multifunctional Fluorescent Ligands for Intracellular Labeling | tinyurl.com/3n55hvsc. With Jason Vevea, Ed Chapman, and @so-lets-kilab70.bsky.social, we combined dye chemistry, HaloTag, microscopy and cell biology to make protein purification and manipulation tools.

A genome-wide atlas of human cell morphology - Nature Methods An optical pooled cell profiling platform (PERISCOPE) based on Cell Painting and optical sequencing of molecular barcodes was used to develop the first unbiased genome-wide morphology-based perturbati...

Our paper “A genome-wide atlas of human cell morphology” is finally out today in @naturemethods.bsky.social ! www.nature.com/articles/s41...

(I tweeted about our preprint in 2023 over at the bad place, but deactivated my account, so here we go again!)

HT1080 cells with various morphologies. DAPI (blue) Phalloidin (grey) GM130 (green).

Advances in microscopy mean we can now do more than just observe biology—we can control it. But how far can we really push this in mammalian cells with all their (beautiful but annoying) heterogeneity? 🧪🔬(🧵)

I still have a few of Lukas's masterpieces around 😂 but even if I use words in notes I often forget what i meant...

It's a terrible time to join any social media, but I'm looking forward to reconnecting to the good old "science twitter" from years ago! Happy to discuss anything #microscopy #cellbio and #biotech 👨‍🔬🔬

Still digesting a lot of new ideas I picked up at #AIM2025 last week. Got inspired to pick up new analysis tools and take a closer look at a few imaging modalities. Stefan Hell's talk on using #minflux for dynamic protein structures was 🤯 as were all the SCAPE applications by Elizabeth Hillman!

Had a nice visit from @interherence.bsky.social and their QuScite today at our lab! Neat waveguide TIRF solution, solid engineering and can be added to any scope. Looking forward to a full demo later this year!