Pereda Lab

Antonio García-Bellido y el hilo de Ariadna de la biología El influyente científico, fallecido el 10 de noviembre a los 89 años, deja una pregunta: cómo las conversaciones entre células controlan el espacio y la forma

"Como pasa con mucho de lo que rodea a la ciencia en España, el nombre no es muy conocido en nuestros lares. La única forma en la que un científico salta al candelero es cuando le dan algún premio, se implica en un escándalo o fallece."

elpais.com/ciencia/2025...

Excited to share our new preprint in collaboration with Ahmet Yildiz's lab. Check out how our team uncovers a novel binding footprint and motor regulation mechanism for MAP9 Congrats to Burak Cetin and @aryantaheri.bsky.social

www.biorxiv.org/content/10.1...

Instruct-NL Develop Clovibactin: The Potential New Antibiotic with Low Resistance Instruct-ERIC is a pan-European research infrastructure in structural biology, making high-end technologies and methods available to all European researchers.

On #EuropeAntibioticAwarenessDay, we highlight the great and impactful work done in structural biology on managing and combatting antibiotic resistance, including work from Markus Weingarth and team at @utrechtuniversity.bsky.social through Instruct-ERIC!

instruct-eric.org/scientifichi...

Cell Press: STAR Protocols STAR Protocols is an open access, peer-reviewed journal from Cell Press. We offer structured, transparent, accessible, and repeatable step-by-step experimental and computational protocols from all are...

2/ For full step-by-step instructions, check out our newly published
@cp-starprotocols.bsky.social
article:

star-protocols.cell.com/protocols/4574

Below is a brief overview of the 5 programs included in the suite.👇

1/ With jamdock-suite, you can automate every major step of virtual screening in a local environment:

🔹 Compound library generation
🔹 Receptor preparation
🔹 Vina docking
🔹 Resuming interrupted runs
🔹 Ranking and analyzing hits

💻 Works on Windows 10/11, Linux, and macOS.

🚀 Interested in large-scale virtual screening using molecular docking?

Meet jamdock-suite:

github.com/jamanso/jamd...

a free toolkit that automates the entire workflow including compound library generation and docking analysis. 🧵

Protocol for an automated virtual screening pipeline including library generation and docking evaluation Here, we present a protocol for an automated virtual screening pipeline. We describe steps for generating compound libraries for computational docking including Food and Drug Administration (FDA)-approved drugs, setting up the receptor and grid box, and docking a library of compounds. We then detail procedures for ranking docking results. This protocol offers scripts for Unix-like systems, lowering the access barrier for researchers interested in structure-based drug disc...

Protocol for an automated virtual screening pipeline including library generation and docking evaluation #protocol #starprotocols #cellpress

Thank you so much for the opportunity to attend your talk at the IBFG 🙌. It was truly inspiring! ✨👏 @palconh.bsky.social

Integrative Structural Biology in the new Instruct-ES Center Madrid - January 29-30, 2026 - Instruct ERIC Spain

Instruct-ES Workshop, Integrative Structural Biology in the new Instruct-ES Center Madrid – January 29-30, 2026, at the IQF Blas Cabrera (CSIC) @iqf-csic.bsky.social @instruct-eric.bsky.social instruct-eric.es/2025/10/10/2... #NMRchat 🧲

Knæk Cancer grant to support new research in DNA repair mechanisms Assistant Professor Pablo Alcón from the Department of Molecular Biology and Genetics has received a three-year Knæk Cancer grant of DKK 3.6 million from the Danish Cancer Society. The project aims to...

Very grateful to the Danish Cancer Society and our MBG colleagues for their support!

This grant will enable us to expand our research scope and grow our team.

mbg.au.dk/en/news-and-...

👉 Don’t miss this opportunity to explore how cells detect and repair dangerous DNA lesions through the Fanconi anaemia pathway and what cutting-edge imaging is revealing about the molecular mechanisms that safeguard our genome.

#DNARepair #Genome #FanconiAnaemia #CancerResearch

Extraordinary Seminar at the IBFG!
📢 Talk by Dr. Pablo Alcón - Aarhus University (Aarhus, Denmark)

🔬Topic: Understanding DNA Repair: Visualizing Tumour Suppressors in Action

🗓 Nov 14, 2025 – 12:00 PM
📍 IBFG Auditorium, Salamanca

(BBSRC NWD) A novel redox mechanosignalling nexus in the synapse that is misregulated in neurodegeneration at University of Liverpool on FindAPhD.com PhD Project - (BBSRC NWD) A novel redox mechanosignalling nexus in the synapse that is misregulated in neurodegeneration at University of Liverpool, listed on FindAPhD.com

🧠 Fully funded 4-year PhD studentship 🧠 Please repost

BBSRC NWD project with @parikki.bsky.social and @iamabyron.bsky.social

Come join us to look at how mechanical and oxidative stress signalling pathways converge on the synaptic scaffold protein talin.

www.findaphd.com/phds/project...

Happy to share that our new paper is now available online @irnasa.bsky.social @usaloficial.bsky.social @unizar.es @uahes.bsky.social
t.co/daOjT5HjC2

Excellent #postdoc opportunity available in @sjorsscheres.bsky.social’ group, working on new image processing algorithms for #cryoEM structure determination in their #RELION open-source software.
www.nature.com/naturecareer...
Apply by 25 NOV
#PostdocJobs #ScienceJobs

SDSC-housed Protein Data Bank Brings Molecules Up to Size Molecules — the unseen architects that form everything from the DNA in your cells to the planets in distant galaxies, crafting the very fabric of reality while remaining too small for the human eye to glimpse. But thanks to the Protein Data Bank we can now “see” these hidden wonders.

Many thanks to the folks at the San Diego Supercomputer Center for highlighting our project!

🌟Aprobada la convocatoria de tramitación anticipada de ayudas a “Proyectos de Generación de Conocimiento” 2025 (#PID2025)

💵700 M€ (+25 M€ que 2024)
➡️Solicitudes 20 nov- 16 de dic 2025
📹Webinario: 18 de nov | 10:30 h.
zoom.us/j/99421301250

www.aei.gob.es/convocatoria...

The Dutch Research Council (NWO) announced large investments in 11 (inter)national research infrastructures this week, and we are very happy that includes investments in our electron microscopy and mass spectrometry facilities, through projects EMPower and BioBeyond-NL:

www.nwo.nl/en/news/nati...

Thrilled, and admittedly relieved, to see this major investment in Dutch #cryoEM become reality! 🇳🇱🔬

Honoured to be a co-applicant on this national initiative and very excited for the opportunity to advance our work in cellular structural virology! 🦠

www.uu.nl/en/news/33-m...

AI in Protein Design: Hype vs. Reality Explained by David Baker In this GEN interview, Nobel Laureate David Baker, PhD, emphasizes that designing proteins from scratch is reality and unpacks what's needed for AI to transform medicine.

AI in Protein Design: Hype vs. Reality Explained by David Baker
In this GEN interview, he emphasizes that designing new proteins from scratch is now a reality. Whether AI transforms medicine will require improving our understanding of biology's complexity

Erice Structural Biology Course 2026 (29 May–6 Jun): apply! Train in Cryo-EM, Cryo-ET & ML to study macromolecular assemblies in cells. Hands-on + theory for next-gen structural cell biology.
🔗 erice2026.azuleon.org/application....
#CryoEM #CryoET #MachineLearning #StructuralBiology #CellBiology

📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu

The mechanical response of vinculin Vinculin buffers force via dynamic domain unfolding/refolding under physiological load and lacks a stable head-tail lock.

Vinculin is a simple adapter protein right? Wrong!

That’s been the prevailing view for the 46 years since it was discovered.

Here we provide a new paradigm and show that vinculin is a complex mechanosensor itself, containing 6 binary switch domains.

www.science.org/doi/10.1126/...

Structural dissection of αβ-tubulin heterodimer assembly and disassembly by human tubulin–specific chaperones Microtubule assembly requires a set of chaperones known as tubulin-binding cofactors (TBCs). We used cryo–electron microscopy to visualize how human TBCD, TBCE, TBCC, and guanosine triphosphatase (GTP...

www.science.org/doi/10.1126/...

Very happy @roman-bushuiev.bsky.social and I joined the amazing team led by @hannes-stark.bsky.social to work on BoltzGen, a generative model for binder design based on Boltz-2. Excited what it will enable!

We are looking for a computational postdoc to work with us on new optimisation algorithms to make #RELION even better. Join our bubbly team at the @mrclmb.bsky.social in Cambridge, UK. 🤗 RTs appreciated.

mrc.tal.net/vx/appcentre...

OpenFold3-preview (OF3p) is out: a sneak peek of our AF3-based structure prediction model. Our aim for OF3 is full AF3-parity for every modality. We now believe we have a clear path towards this goal and are releasing OF3p to enable building in the OF3 ecosystem. More👇

Congrats to Óscar Herranz from our sister lab lead by Carmen Guerrero.
Óscar received the prize "Health & Wellbeing, experimental research" for his PhD thesis:
“Impact of C3G on hematopoiesis after myeloablation. Effects on hematopoietic precursors and megakaryocyte niche function.

Ayer se entregaron los Premios Alumni USAL.
Muchas felicidades a los galardonados. En particular a Óscar, Sofia, Javier y Alba del @ciccancer.bsky.social

MRC DiMeN Doctoral Training Partnership: The intersection of mechanical signalling and the hypoxic response as a targetable signalling nexus in pancreatic cancer at University of Liverpool on FindAPhD... PhD Project - MRC DiMeN Doctoral Training Partnership: The intersection of mechanical signalling and the hypoxic response as a targetable signalling nexus in pancreatic cancer at University of Liverpo...

*Fully funded 4-year PhD studentship available*

This MRC DiMeN DTP funded project will look at the direct interactions between talin and the hypoxic response machinery to define the protective mechanisms at play in cells that protect against oxygen depletion

www.findaphd.com/phds/project...