Brain Stimulation Journal

Great News! Brain Stimulation Journal’ s Impact Factor increased to 8.4! Science Citation Index ranking is now 18 of 314 titles in Neurosciences & 13 of 285 in Clinical Neurology. A big thank you to our authors, reviewers, readers & contributors! Here’s to advancing impactful science together!!

Bilateral Intermittent Theta Burst Stimulation Using a Double-Cone Coil for Major Depressive Disorder: Findings from a Single-Center Experience Treatment-resistant depression (TRD) remains a significant clinical challenge, necessitating the exploration of alternative interventions to improve treatment outcomes. Transcranial magnetic stimulati...

Burç Çağrı Poyraz and colleagues show that bilateral intermittent theta burst stimulation with a double-cone coil can be effective for depressive symptoms and to address anxiety with major depressive disorder (MDD)
www.brainstimjrnl.com/article/S193...

Spinal Cord Ultrasound Stimulation Modulates Corticospinal Excitability in Humans Low-intensity focused ultrasound offers deep tissue penetration and holds promise as a noninvasive tool for neuromodulating brain circuits. However, its effects on neural activity within the human spi...

Lin Hou & Yuming Lei demonstrate that spinal corn ultrasound stimulation (SCUS) is a promising noninvasive technique for spinal neural circuits in humans.
www.brainstimjrnl.com/article/S193...

Accelerated anxiosomatic circuit TMS: An open-label pilot study in Chinese participants with a treatment-resistant anxiety-related disorder Anxiety-related disorders are extremely common and frequently disabling (1). Current treatments are associated with high drop-out and non-response rates, necessitating new approaches. Transcranial mag...

Huiru Cui et al
provide preliminary support for the effectiveness, safety, and generalizability of anxiosomatic circuit aiTBS for treatment-resistant anxiety alleviating symptoms and improving overall functioning.
www.brainstimjrnl.com/article/S193...

Improving Cerebellar TMS Targeting: MRI-Neuronavigation and Landmark-Based Approaches Assessed by E-Field Modeling Transcranial magnetic stimulation (TMS) is widely employed to modulate cerebellar activity [1]. Although neuronavigation is widely used to target cortical regions, cerebellar TMS is still predominantl...

Vridhi Rohira & colleagues propose combining magnetic resonance imaging (MRI)-based neuronavigation on a cerebellar spatially unbiased atlas template SUIT atlas to improve cerebellar TMS targeting.

www.brainstimjrnl.com/article/S193...

Multi-locus transcranial magnetic stimulation with pulse-width modulation In transcranial magnetic stimulation (TMS), a pulse of current driven through a coil on the scalp induces an electric field on the cortex, eliciting neuronal activation. Multi-locus TMS (mTMS) uses mu...

In a recent study Heikki Sinisalo & colleagues investigate whether the issue of rapid pulse delivery to different cortical targets can be overcome by multi-coil TMS combined with pulse-width modulation (PWM) in microsecond scale

www.brainstimjrnl.com/article/S193...

Accelerated iTBS-Induced Changes in Resting-State Functional Connectivity Correspond with Cognitive Improvement in Amnestic MCI Published results of our Phase I safety and feasibility trial of accelerated intermittent theta burst stimulation (a-iTBS) in mild cognitive impairment (MCI) due to Alzheimer’s disease showed a large ...

Stephanie Aghamoosa et al. shows that Accelerated iTBS for amnestic MCI linked to cognitive improvement AND changes in brain connectivity.
Increased segregation in target networks (DMN, VAT) and local DMN connectivity correlate with better cognition.

www.brainstimjrnl.com/article/S193...

Saeed Makkinayeri & team use Hidden Markov Models to define TMS-EEG brain states with distinct spectral, temporal and spatial features linked to fMRI networks. Interestingly, the sensorimotor network engagement boosts MEP amplitudes.

www.brainstimjrnl.com/article/S193...

Comparing analgesic effects of temporal interference stimulation on ventral posterolateral thalamus and high-definition transcranial alternating current stimulation on sensorimotor cortex during susta... The quest for non-invasive, effective, and safe pain relief methods has driven extensive research. The sensorimotor cortex (SM1) is essential for pain localization, processing signals from the thalamu...

Jixin Liu et al evaluate analgesic effects during and after stimulation using tTIS on VPL and HD-tACS on SM1 showing α-tACS applied to the SM1 produced a significant pain-relieving effect during the post-stimulation phase.

www.brainstimjrnl.com/article/S193...

Jodoin and team report first open-label study of a spaced tDCS protocol for MDD, demonstrating strong feasibility, safety, and preliminary therapeutic effects.

www.brainstimjrnl.com/article/S193...

Case evidence of connectivity-guided intermittent theta burst stimulation for the treatment of autism spectrum disorder Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by social communication and interaction impairment as well as stereotyped behaviors and restricted interests. It i...

Case study by Li-Xia Yuan & team for personalized #TMS in #ASD! Connectivity-guided iTBS targeting DLPFC-NAc circuitry reduced repetitive behaviors by 72%, with effects lasting 3 months. Imaging revealed functional & structural changes in reward system

www.brainstimjrnl.com/article/S193...

Accelerated iTBS with a personalised targeting method to treat negative symptoms of schizophrenia: A randomized controlled trial The efficacy of non-invasive brain stimulation in ameliorating schizophrenia’s negative symptoms remains to be validated. The mesocortical pathway, mostly comprising the ventral tegmental area (VTA) and prefrontal cortex, is the core neural circuit underlying negative symptoms. This study aimed to assess the clinical and biological effects of accelerated intermittent theta burst stimulation (iTBS) targeted to the dorsolateral prefrontal cortex (dlPFC), guided by personalised dlPFC-VTA functional connectivity (FC).

Yunyi Han, Fang Jin and team publishes: Accelerated personalized iTBS targeting brain circuits (dlPFC-VTA) significantly reduces negative symptoms in schizophrenia vs. sham (Cohen’s d=0.83). Imaging changes linked to improvement.

www.brainstimjrnl.com/article/S193...

A fantastic talk by recipient of 2025 Early Career Award winner at 6th Int’l Brain Stim Conf, Dr. Andreas Horn on effects of deep and superficial brain stimulation on various neural circuits.

Another fantastic Plenary session at 6th Int’l Brain Conf: Randy Nudo discusses current mechanisms underlying stimulation-induced neuroplasticity in recovery outcomes.

Amazing talk by recipient of 2025 Int’l Brain Stim Award, Prof. Walter Paulus, on history of brain stim, lessons learned & generalizing treatment approaches in neurological/psychiatric diseases at 6th Int’l Brian Stim Conf

Plenary session at 6th Int’l Brain Stim Conference: Prof. Charlotte Stagg discussing Breakthrough in Precision Stimulation for Targeted Motor Control #BrainStimConf Feb 23-26, 2025, Kobe, Japan

Plenary session at 6th Int’l Brain Stim Conference: Marom Bikson presents on Wearable Brain Stimulation #BrainStimConf Feb 23-26, 2025, Kobe, Japan.

Conference - International Brain Stimulation Conference - About This sixth international meeting, organized by Elsevier and sponsored by and integrated with the journal Brain Stimulation.

6th Int’l Brain Stimulation Conference in Kobe, Japan, starts next week! Don’t miss this dynamic program featuring cutting-edge research, and innovative advancements shaping the future of brain stimulation. See you there! #BrainStimConf #BrainStimulation www.elsevier.com/events/confe...

Conference - International Brain Stimulation Conference - About This sixth international meeting, organized by Elsevier and sponsored by and integrated with the journal Brain Stimulation.

6th Int’l Brain Stim Conference in Kobe, Japan, will showcase groundbreaking research, multidisciplinary panels & transformative advancements in brain stimulation. Be part of the future! #BrainStimConf #NeuroInnovation www.elsevier.com/events/confe...

Next month in Kobe, Japan: Int’l Brain Stim Conference! extraordinary scientific program groundbreaking research and multidisciplinary discussions, register today! #BrainStimulationhttps://www.elsevier.com/events/conferences/international-brain-stimulation-conference

International Brain Stimulation Conference | Sponsors & Exhibitors | Elsevier International Brain Stimulation Conference - Sponsors & Exhibitors

The 6th Int’l Brain Stimulation Conference will feature industry-sponsored workshops showcasing the latest tech & practical applications. Learn directly from innovators in the field! #BrainStimConf #NeuroTech www.elsevier.com/events/confe...

Conference - International Brain Stimulation Conference - About This sixth international meeting, organized by Elsevier and sponsored by and integrated with the journal Brain Stimulation.

The 6th International Brain Stimulation Conference in Kobe, Japan is just over a month away! Explore the latest breakthroughs and therapies in brain stimulation. Delegate places still available—register now! #BrainStimConf #BrainStimulation www.elsevier.com/events/confe...

Conference - International Brain Stimulation Conference - About This sixth international meeting, organized by Elsevier and sponsored by and integrated with the journal Brain Stimulation.

We’re delighted Plenary and 2025 Int. Brain Stimulation award winner, Walter Paulus @yourUMG will present “Lessons from 225/40/25 Years of Quantitative Transcranial Stimulation” at #BrainStimConf. Last chance to register & save, deadline today. www.elsevier.com/events/confe...

Conference - International Brain Stimulation Conference - About This sixth international meeting, organized by Elsevier and sponsored by and integrated with the journal Brain Stimulation.

Discuss ‘noninvasive brain stimulation for dementing disorders -from bench to bedside for bright future’ w/ #BrainStimConf Plenary Takenobu Murakami @tottori_univ. Registration discount deadline Friday (6 Dec). www.elsevier.com/events/confe...