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Mac Shine

@macshine.bsky.social

Computational Neurobiologist from Sydney, Australia. https://shine-lab.org

2,940 Followers  |  2,322 Following  |  69 Posts  |  Joined: 30.07.2023  |  1.7748

Latest posts by macshine.bsky.social on Bluesky

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🚨 California and Hawaii under tsunami watch after 8.7M quake in Eastern Russia.

30.07.2025 01:09 β€” πŸ‘ 1578    πŸ” 590    πŸ’¬ 99    πŸ“Œ 76
Tsunami Warning

Tsunami Warning

Tsunami Warning – 7/30, 9:40am
The Tsunami Advisory has been upgraded to a Tsunami Warning. Waves of up to 3m are expected. Those near coastal areas, rivers, or lakes should evacuate to higher ground immediately. #tsunami

30.07.2025 00:53 β€” πŸ‘ 274    πŸ” 154    πŸ’¬ 8    πŸ“Œ 13
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Evolutionary trade-off between vocal tract and testes dimensions in howler monkeys - PubMed Males often face a trade-off between investments in precopulatory and postcopulatory traits [1], particularly when male-male contest competition determines access to mates [2]. To date, studies of pre...

The point is, the monkeys making the loudest noise have the smallest balls.
pubmed.ncbi.nlm.nih.gov/26592343/

27.07.2025 20:28 β€” πŸ‘ 28    πŸ” 4    πŸ’¬ 2    πŸ“Œ 0

Dem leadership should appoint an official Alt Press Secretary to give briefings after every one that Karoline Leavett does and just break them down lie by lie

maybe THAT’S the job we give Colbert πŸ˜‚

22.07.2025 00:10 β€” πŸ‘ 1750    πŸ” 318    πŸ’¬ 48    πŸ“Œ 31
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An exciting collaboration is underway. @thetransmitter.bsky.social is partnering with @neuromatch.bsky.social to serve the computational neuroscience community and help connect neuroscientists across all career stages.
www.thetransmitter.org/neuromatch-p...

#neuroskyence

18.07.2025 14:27 β€” πŸ‘ 73    πŸ” 22    πŸ’¬ 2    πŸ“Œ 0
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β€œthe kindest person in the room is often the smartest.” JB Pritzker is a mensch.

17.07.2025 01:20 β€” πŸ‘ 9194    πŸ” 2716    πŸ’¬ 281    πŸ“Œ 228
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Prefrontal axons going to lots of places!
doi.org/10.1016/j.ce...
#neuroskyence

15.07.2025 16:50 β€” πŸ‘ 47    πŸ” 10    πŸ’¬ 2    πŸ“Œ 0
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Cooperative thalamocortical circuit mechanism for sensory prediction errors - Nature Experiments in mice show that a cortico-thalamic circuit generates prediction-error signals in primary visual cortex that amplify visual input that deviates from animals’ expectations.

Pairs well with www.nature.com/articles/s41...

β€œOur results indicate that individual V1 neurons do not signal how the actual visual input deviates from the animal’s predictions, as postulated within the predictive coding framework”

Thrilling to see a major theory get tested!

11.07.2025 19:50 β€” πŸ‘ 56    πŸ” 11    πŸ’¬ 3    πŸ“Œ 1
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GLP-1 and the Neurobiology of Eating Control: Recent Advances Abstract. Obesity is now considered a chronic relapsing progressive disease, associated with increased all-cause mortality that scales with body weight, af

Really proud to start the year by sharing our new review in @endosocjournals.bsky.social on the roles of GLP-1 in eating and obesity treatment, led by superstar postdoc @laurenjonesucl.bsky.social!

academic.oup.com/endo/article...

πŸ§ͺπŸ§ πŸ“ˆ #neuroscience #neuroskyence #GLP-1 #obesity #wegovy #ozempic

21.01.2025 11:59 β€” πŸ‘ 83    πŸ” 22    πŸ’¬ 5    πŸ“Œ 1

I honestly think we should have a screening system for who gets to have money and influence based on asking "what was Star Wars about?" and "who were the good guys?"

09.07.2025 08:08 β€” πŸ‘ 43    πŸ” 8    πŸ’¬ 5    πŸ“Œ 0
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Molecular and functional diversity of the autonomic nervous system - Nature Reviews Neuroscience The autonomic nervous system has long been viewed as a simple motor system in brain-to-body signalling. In this review, Wang and colleagues highlight diversity within autonomic neurons and their dynam...

Molecular and functional diversity of the autonomic nervous system β€” a Review by Tongtong Wang, Avedis Tufenkjian, Olujimi A. Ajijola & Yuki Oka

#neuroscience #neuroskyence

www.nature.com/articles/s41...

07.07.2025 08:30 β€” πŸ‘ 20    πŸ” 6    πŸ’¬ 0    πŸ“Œ 0

Exciting new preprint from the lab: β€œAdopting a human developmental visual diet yields robust, shape-based AI vision”. A most wonderful case where brain inspiration massively improved AI solutions.

Work with @zejinlu.bsky.social @sushrutthorat.bsky.social and Radek Cichy

arxiv.org/abs/2507.03168

08.07.2025 13:03 β€” πŸ‘ 124    πŸ” 55    πŸ’¬ 3    πŸ“Œ 10
Function over form: The temporal evolution of affordance-based scene categorization | JOV | ARVO Journals

🚨 New paper in Journal of Vision!
We show that scene affordancesβ€”what you can do in a spaceβ€”shape how we perceive and categorize scenes. This shapes your similarity preferences, predicts your categorization false alarms, and even alters neural representations. πŸ§΅πŸ‘‡
πŸ”— doi.org/10.1167/jov....
(1/7)

08.07.2025 16:38 β€” πŸ‘ 26    πŸ” 9    πŸ’¬ 3    πŸ“Œ 0
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Attractors are usually not mechanisms The mathematical objects can not be. And the "attractor models" have not been established as mechanisms in mammals

Attractors are usually not mechanisms - new blog post: open.substack.com/pub/kording/...

08.07.2025 14:40 β€” πŸ‘ 150    πŸ” 33    πŸ’¬ 19    πŸ“Œ 9
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How does the human brain coordinate hierarchical cortical development? Our work in Nature Neuroscience identifies a role for thalamocortical structural connectivity in the expression of hierarchical periods of cortical plasticity & environmental receptivity in youth 🧡 www.nature.com/articles/s41...

08.07.2025 00:00 β€” πŸ‘ 119    πŸ” 44    πŸ’¬ 4    πŸ“Œ 8
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Spared spatial imagery solves the puzzle of aphantasia

Short new piece on aphantasia just out in TiCS: www.sciencedirect.com/science/arti... Key idea: aphantasia often involves a lack of *visual-object* imagery (explaining subjective reports & objective correlates) but selectively spared *spatial* imagery (explaining preserved task performance).

28.06.2025 13:10 β€” πŸ‘ 22    πŸ” 3    πŸ’¬ 1    πŸ“Œ 0
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fMRI must break out of its silo We need to develop research programs that link phenomena across levels, from genes and molecules to cells, circuits, networks and behavior.

ICYMI: β€œFor fMRI to meaningfully contribute to progress in neuroscience, we need to develop research programs that link phenomena across levels,” writes Avram Holmes @avramholmes.bsky.social.

www.thetransmitter.org/future-of-fm...

26.06.2025 19:44 β€” πŸ‘ 9    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0

Another great article from @thetransmitter.bsky.social and Laura Lewis, who has been working painstakingly over the last few years to help ramp up the spatiotemporal resolution of fMRI so that we can really start to dig into whole-brain signals in vivo.

25.06.2025 21:13 β€” πŸ‘ 6    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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fMRI can do more than you think Advances in brain imaging technology provide new and different information about the brain.

ICYMI: Recent technological advances in functional MRI provide a range of new information about brain physiology. Collaboration between engineers and neuroscientists will help maximize these gains, writes Laura Lewis.

www.thetransmitter.org/human-neurot...

25.06.2025 16:19 β€” πŸ‘ 29    πŸ” 9    πŸ’¬ 1    πŸ“Œ 3
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Modeling the influences of non-local connectomic projections on geometrically constrained cortical dynamics The function and dynamics of the cortex are fundamentally shaped by the specific wiring configurations of its constituent axonal fibers, also known as the connectome. However, many dynamical propertie...

Paper is here: arxiv.org/abs/2506.19800
Code is here: github.com/DynamicsAndN...

If you're interested and at #OHBM2025 come watch Rishi present his work in the "Modeling and Analysis - Connectivity" workshop on Saturday in the Great Hall; and check out his poster #1440 (on Friday & Saturday)

25.06.2025 05:02 β€” πŸ‘ 5    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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New preprint!

Why are long-range connectomic interactions in the cortex dominant in shaping dynamics in some experiments but apparently negligible in others?

We (w/ R Maran, @elimuller.bsky.social) address this question by studying a new hybrid model of cortical dynamics.

arxiv.org/abs/2506.19800

25.06.2025 05:02 β€” πŸ‘ 40    πŸ” 14    πŸ’¬ 1    πŸ“Œ 0
OSR Petition We are launching a petition to request that OHBM preserves the Open Science Room (OSR) as a dedicated space during the annual meeting for the Open Science community. Although Open Science is a well-ac...

The Open Science Room has been an exciting space at the OHBM Meeting for many years, but its future is threatened. Please sign this petition to signal your support for preserving a dedicated space for the OSR at future meetings. ohbm.github.io/osr2025/peti...

24.06.2025 22:44 β€” πŸ‘ 30    πŸ” 14    πŸ’¬ 1    πŸ“Œ 1

agreed. makes it really tricky to bounce between sessions effectively...

24.06.2025 01:00 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Useful #OHBM2024 deep link - Table listing all posters with stand-by times & categories

gmpartners365-my.sharepoint.com/:x:/g/person...

24.06.2025 00:20 β€” πŸ‘ 7    πŸ” 4    πŸ’¬ 3    πŸ“Œ 0

Major congrats, mate! I can't wait to see what you and your group come up with...

23.06.2025 21:29 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Fantastic article from one of the leaders of the burgeoning field or layer-resolved functional MRI. A pleasure to read!

23.06.2025 21:25 β€” πŸ‘ 8    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Imaging cortical layers to understand brain as network organ This spatial scale, bridging cells and brain areas, has been overlooked in human brain research. But advances in fMRI technology are changing that.

ICYMI: In this essay for our Future of fMRI series, Laurentius Huber @layerfmri.bsky.social explains how new advances in functional MRI could help to connect cells and brain areas at the mesoscopic scale.

#neuroskyence #OHBM2025

www.thetransmitter.org/future-of-fm...

23.06.2025 15:39 β€” πŸ‘ 18    πŸ” 7    πŸ’¬ 1    πŸ“Œ 1
Bridging the epistemological divide in neuroscience to improve ontological clarity | Published in Aperture Neuro By Giulia Baracchini, Eli Muller & 1 more. This perspective highlights the epistemological divide that arises from the wide variety of different experimental approaches... which in turn lead to ontolo...

The diversity of methods we use to probe the brain (epistemologies) naturally leads to clashes in our theories of how the brain works (ontologies). So how do we reconcile this divide and grow into a more unified neuroscience? Here is our take:
apertureneuro.org/article/1388...

20.06.2025 22:27 β€” πŸ‘ 7    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0
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🧠 The State of the Brain Special Issue features insights from last year’s keynotes, award winners & committee leaders.

πŸ”— Explore major findings & themes from 2024: apertureneuro.org/issue/12560

@arokem.org @alexfornito.bsky.social @macshine.bsky.social @vcalhoun.bsky.social @misicbata.bsky.social

20.06.2025 18:21 β€” πŸ‘ 13    πŸ” 7    πŸ’¬ 0    πŸ“Œ 2

Oh cool. I really love Matthew Larkum's work on the neural substrates of consciousness too, though he and I have not yet had a deep discussion about intralaminar thalamus just yet ;)

11.06.2025 20:31 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

@macshine is following 20 prominent accounts