Anton Goloborodko

What an utter travesty

Joint decomposition of Hi-C maps reveals salient features of genome architecture across tissues and development The spatial organization of chromosomes in the nucleus is fundamental to cellular processes. Contact frequency maps from Hi-C and related chromosome conformation capture assays are increasingly availa...

We're excited to share our new preprint, "Joint decomposition of Hi-C maps reveals salient features of genome architecture across tissues and development", led by Thomas Reimonn. www.biorxiv.org/content/10.1...

So love this explanation of the deification of AI and the singularity, sent to me by my son

RNA Pol II-based regulations of chromosome folding How transcription and cohesin complexes interact to regulate 3D genome organization remains unclear. Chapard et al. dissect their respective contributions and their interplay in shaping the genome arc...

Pleased to see this study out, combining experimental work from our lab at the @cbitoulouse.bsky.social, in particular by @nathaliebastie.bsky.social and @beckof.bsky.social, and from Laura Chaptal and @alengronne.bsky.social at IGH Montpellier
@cnrs.fr @cnrsbiologie.bsky.social

Congrats to all!

TIL MacBooks have accelerometers!

🧬 Check out our latest paper in the PRL: doi.org/10.1103/7fh5...

We use computer simulations and analytically solvable theory to study supercoiled DNA plasmids functionalized by pH-responsive groups. We show how charge annealing can reversibly switch the topological twist to writhe and vice versa.

Why not parquet (for the data that fit into a table well)?

Biozentrum PhD Fellowships Share your passion for life sciences. If you are talented and highly motivated, want to broaden your horizons and are interested in a wide range of research topics, apply for one of the sought after B...

Apply now for the prestigious and independent #BiozentrumPhDFellowships. Great science. Unique rotation-based selection of research group and other incentives. The summer call is open until October 12, 2025. bit.ly/4caiqqX @biozentrum.unibas.ch @unibas.ch #fellowship #PhD#Switzerland

DOC Fellowships awarded to numerous Vienna BioCenter Phd Students The Austrian Academy of Sciences (ÖAW)’s DOC Fellowship program supports outstanding PhD students by funding their innovative research projects. This year, no less than 13 talented PhD Students at the...

The Austrian Academy of Sciences (ÖAW)’s DOC Fellowship program supports outstanding PhD students by funding their innovative research projects. This year no less than 13 talented PhD Students at the Vienna BioCenter received this highly competitive fellowship
www.viennabiocenter.org/about/news/d...

bottom line: the host is unable to launch a piRNA response unless the transposon inserts itself into an exon of a host gene expressed in gonads. The data is so black and white that it was a true pleasure to put the paper together. Baptiste’s experimental skills are showcased in the data/figures.

piRNAs are essential for transposon silencing in the animal germline.
But how do hosts trap transposon sequences in genomic loci that help establish a piRNA response?

Looking at a natural transposon invasion, Baptiste Rafanel and Kirsten Senti made some remarkable observations.

At first, I thought it was Lenin! (childhood trauma)

Just 2 weeks left!

The Vienna BioCenter PostDoc Program is still accepting applications. We have 16 fully-funded fellowships available for researchers in biology, chemistry, physics, bioinformatics, and more.

Apply now: training.vbc.ac.at/post-docs/vi...

#VBCPostDoc

Group Leader - Genome Biology Unit Are you ready to lead groundbreaking research in Genome Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group addressing exciting and original biological...

To all post-docs: The Genome Biology dept ‪@embl.org
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

What a happy day - congratulations!!

last call!
submit your abstract by tonight to be selected for one of the many oral presentations at the leading European Transposon Meeting. We are very much looking forward to your contribution and attendance!

Head of the Cell Biology and Biophysics Unit The European Molecular Biology Laboratory (EMBL) is Europe’s flagship life sciences organisation, and one of the world’s leading research institutions. An intergovernmental organisation of 29 Member S...

EMBL Cell Biology and Biophysics department is searching for a new director. A major position to lead this field in Europe and beyond.
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

A twitter post explaining how you can “save PNGs to birds” by converting a drawing of a bird into a spectrogram then playing it to a starling who sung it back, reproducing the PNG.

Can’t wait to introduce bird-based storage into my backup system

Amazing stuff. I'd like to point you to the incredible graphical abstract for this recent Cell manuscript.

doi.org/10.1016/j.ce...

Great opportunity! The Uni Vienna has launched a call (APART) for 4-funding for outstanding postdocs from a US institution. The host lab has to nominate by 1 August a candidate for further selection. Anyone interested in our work please contact me by email with CV/motivation letter. Hurry up!

Scalable Chrysopoeia via $(n, 2n)$ Reactions Driven by Deuterium-Tritium Fusion Neutrons A scalable approach for chrysopoeia - the transmutation of base metals into gold - has been pursued for millennia. While there have been small-scale demonstrations in particle accelerators and proposa...

So Tokamak Fusion reactors can be used to generate gold from mercury - preprint from Marathon Fusion scientists #QuantumAlchemy 🤯😳- arxiv.org/abs/2507.13461

Bioinformatics Developer About the team and role The Ensembl Project based at the European Bioinformatics Institute (EMBL-EBI) develops free, comprehensive genome data services for a worldwide audience, distributing gene and ...

🧬💻 We're hiring a #Bioinformatics #Developer @emblebi.bsky.social! Join the @ensembl.bsky.social Variation team building open-source tools to support global research & clinical genomics. Collaborative team; real impact.
👉 Apply: embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
⏰ Deadline: 10 August

Apply for the AITHYRA-CeMM International PhD Program!

15-20 fully funded PhD fellowships available in Vienna, AT
in AI/ML and Life Sciences

Deadline for applications:
10 September 2025 apply.cemm.at

Tenure-track faculty search of the UCSF Biochemistry & Biophysics Department is open for applications!

We are looking for creative, innovative scientists asking fundamental questions in any area of biology.

Join our vibrant, collaborative, and supportive community!

aprecruit.ucsf.edu/JPF05702

Global inhibition of deadenylation stabilizes the transcriptome in mitotic cells In the presence of cell division errors, mammalian cells can pause in mitosis for tens of hours with little to no transcription, while still requiring continued translation for viability. These unique...

New preprint! We solve a mystery you didn't know existed. Mitotic cells lack new transcription but require ongoing translation. Interphase mRNA half life is only 2-4 hrs. So how do cells arrest in mitosis for hours without depleting their transcriptomes?

www.biorxiv.org/content/10.1...

Horizon Europe 2028 - 2034: twice bigger, simpler, faster and more impactful Research and innovation news alert: As part of the next long-term EU budget 2028-2034, the Commission is proposing to double the budget of the research and innovation framework programme to €175 billi...

Very promising news on the next seven-year EU budget, with a proposed substantial increase for Horizon Europe including the ERC.

We are analysing the other parts of this proposal in more detail.

@Vonderleyen @EZaharievaEU

research-and-innovation.ec.europa.eu/news/all-res...

And another opportunity! Any postdocs looking forward to start your lab on a tenure track? Supportive environment, great core facilities and an outstanding PhD program.

1 month to abstract deadline for the first cell biology of the nucleus meeting at @embl.org in many years - organised by the stellar @luskinglab.bsky.social @sarawickstrom.bsky.social Tom Quail & Simone Koehler

Tons of open slots, invited and selected speakers all get 20 mins ❤️

#EESNucleus

We are on the lookout for postdocs for two different projects at the intersection of ecology, evolution, and the human microbiome.

See thread for more information and reach out!

It’s actually even worse: they show it as a gel, which is pure fluorescence units, but a BioAnalyzes records as the molecules pass a single point sensor and critically _fails to normalize for different molecule speeds_

This results in a near-logarithmic overcounting of large molecules!