Anton Goloborodko

Ubiquitin & Friends Fiesta in Vienna, 29-30 April 2026.
Great speakers, small size, a friendly community, perfect for early-career researchers to connect with fellow ubiquitin enthusiasts. Sign up at www.protein-degradation.org/symposium/ and submit abstracts for talks and awards.
#ubfriends26

Pls re-post: My department @oxfordbiochemistry.bsky.social are recruiting for several new faculty positions (links below). Broad search in molecular biology/biochemistry, across prokaryotes and eukaryotes. Interested in understanding life at the molecular level, this job might be for you!
1/n

i agree with the message - but has this Claude-using-old-data hypothesis been supported by anything? All I saw so far is another output by Claude, even if the hypothesis is entirely plausible

I have so many examples of students questioning whether I know enough about a topic to teach it. I asked in faculty meeting "who has been questioned whether they are qualified to teach a class?" The women raised their hands, the men didn't. It's definitely rooted in sexism and racism.

Exciting news:
Our RNA community in @uniregensburg.bsky.social is set to grow!

We are opening a Junior Group Leader position in RNA biochemistry / ribonucleases / RNA stability. A great opportunity to start your own team within our collaborative RNA network.

Details & application 👇

Our Lab is searching a postdoc for an exciting ERC-funded project that will start this summer. Apply if you’re passionate about multi-omics, cutting-edge computational approaches, and exploring biological questions across the animal 🪼 🪱 🐞 🦎 🦋 🕷️ tree of life www.biozentrum.unibas.ch/open-positio...

If you want to explore ncRNA dynamics during mammalian development, love microscopy, and are not afaraid of transposons biology, apply‼️
We are looking for a postdoc to join our team at @imbavienna.bsky.social
More details 👇🏻

Black and white illustration featuring a forest setting with central hippo like creature, hedgehog in the foreground and birds flying overhead

Illustration from Tove Jansson's book 'The Moomins and the Great Flood' (1945) #Womensart

But the usage limits are tough. When I use opus 4.6, i run out of tokens every day. Sonnet 4.6 is cheaper, but still quite good

I now use opus 4.6 for similar questions in an easier project and, for the first time, it feels actually useful. Eg I asked it to generate a checklist to evaluate a narrative and the logical structure of a paper and it gave me something very reasonable (i spent a decade formulating this for myself)

A bit hard to compare, although, I did have access to gpt 5.2 and opus 4.6 temporarily. I used both to solve difficult writing questions (e.g. exploring narratives and framing) and both were more or less a waste of time. Opus had a better style, but gpt 5.2 seemed to think harder.

I switched two or three years ago and never looked back.

It's the markets

Incredibly proud to share our new preprint, lead by the Incomparable Rithika Sankar.
Here we temporally dissect the role of FACT in mES cells, finding that FACT loss drives progressive deterioration of chromatin architecture, leading to transcriptional collapse.
www.biorxiv.org/content/10.6...

1/New preprint just dropped! 🔥🔥 We investigate how the genome is destroyed in apoptotic cells in a way that prevents DNA fragments from spreading beyond the dying cell 🧬⚰

Done here at @imbavienna.bsky.social & in the super @rcollepardo.bsky.social & Rosen labs:

www.biorxiv.org/content/10.6...

🧬 @danielibrahim.bsky.social, moderated by @stefanschoenfelder.bsky.social, on enhancer-promoter specificity & how promoter-proximal regions act as molecular filters.

Register: us02web.zoom.us/webinar/regi...

March 5, 4PM UK.

#Genomics #GeneRegulation

I've been trying to make LLMs help me analyse my drafts and explore alternative narratives for the past 1-2 years. Opus 4.6 is the first model that doesn't feel like a waste of time. Previous LLMs were best at rubber-ducking, with neutral-to-negative time gains; Opus 4.6 feels insightful

MDAnalysis is participating in #GSoC 2026!

👉 Read our blog post for details on how you can apply to work with MDAnalysis through GSoC: www.mdanalysis.org/2026/02/19/g...

🗓️ Pre-proposals must be submitted by March 9.

❗For transparency and fairness, use public forums for all #GSoC communications.

LINE-L1, HIV, Ty3 retrotransposons in insects.
several of these genomes are > 40% adenosine!

What is the molecular origin & evolutionary pressure resulting in A-rich genomes of retrotransposons & some retroviruses?

it must be so hardwired that hosts exploit this bias for genome defense

any ideas?

Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳

mrc.tal.net/vx/mobile-0/...

🤯🤯🤯

The Faculty has recently opened a wide variety of PhD positions dealing with fascinating physical phenomena, from isotopes to spin waves and carbon nanotubes to low-dimensional materials!

⁉️Want to know more?⁉️ All the information in the link below 👇

🔗 a29.at/3k85aW

The demystification of piRNA clusters

if you wonder how cells generate piRNAs specifically against transposons & you are looking for a weekend read

check out @86dominik.bsky.social's opus magna (or Dominik's great thread)

a shared project with the one and only Rippei Hayashi, lab alumnus & friend

How does the piRNA pathway solve the self vs. non-self problem? 🧬

Since piRNAs come from single-stranded RNA, how does the cell choose the right ones? For years, "piRNA clusters" were seen as THE privileged source. But are they really special and earmarked for biogenesis? (1/19)

A small polymerase ribozyme that can synthesize itself and its complementary strand The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...

Why hasn't this paper gotten more attention?

"Moderna's CEO announced the company will no longer invest in new Phase 3 vaccine trials for infectious diseases: 'You cannot make a return on investment if you don't have access to the U.S. market. Vaccines for Epstein-Barr virus, herpes, and shingles have been shelved.” 9:12 AM Feb 12, 2026 604.8K Views

In terms of what cures are being lost:

- Epstein-Barr virus is perhaps the major trigger for multiple sclerosis
- herpes simplex virus causes cold sores, genital herpes, infections in babies, deadly meningitis
- shingles virus causes an intensely painful disease

Interested in transcriptional regulation, enhancers and 3D genome folding?

In this new study we wondered about the role of cohesin loading at enhancers for long-range transcriptional control

www.biorxiv.org/content/10.6...

detailed 🧵👇

Disappearance of a massive star in the Andromeda Galaxy due to formation of a black hole When a massive star reaches the end of its lifetime, its core collapses and releases neutrinos that drive a shock into the outer layers (the stellar envelope). A sufficiently strong shock ejects the e...

www.science.org/doi/10.1126/...

Happy birthday to one of my favourite haters, Charles Darwin

NOW LIVE!: PhD opening joint with @drjonbaxter.bsky.social at @gdsc-sussex.bsky.social
Get in touch and apply if you are interested in any and all of: Chromosomes, Genome Stability, Chromatin and DNA Topology in Mitosis and Meiosis.
www.sussex.ac.uk/study/fees-f...