Kathleen Farley

Here is the link to nominate: americanchemical.co1.qualtrics.com/jfe/form/SV_...

Make a nomination! The 2026 Philip A. Portoghese Early Career Award for the Advancement of Medicinal Chemistry recognizes two outstanding early career investigators in the field of medicinal chemistry research.

The deadline for nomination is December 1, 2025. Thank you! #ACSMedChemLett #JMedChem

SMASH 2025 is kicking off with a session on Accelerating Small Molecule Drug Innovation moderated by Daneen Angwin-Kaerner #NMR #SMASH2025

@rrgil.bsky.social kicking off the Early Career Researcher’s Symposium sponsored by Magnetic Resonance in Chemistry (MRC) at the SMASH NMR meeting in Porto, Portugal. #Smash2025 #nmr

How the Trump Administration Is Dismantling America’s Cancer-Research System

Reading today’s big NYT Magazine story made me physically sick

It details how Trump & the men he put in charge of federal research—men like Jay Bhattacharya & RFK Jr—are dismantling cancer research

Not just the US vaccine system—they’re crushing cancer R&D

🎁Link

www.nytimes.com/2025/09/14/m...

Hopefully you got some Ben & Jerry’s ice cream at the Doty probe booth!

Art Institute would be on my list

Table showing the massive cuts in federal science funding for EPA- 54.5%, NASA -24%. NOAA - 24%, NSF -56%, USGS- 38% etc.

This is just a partial glimpse of the destruction of American science by Trump and the GOP.

This is no way to run a bagel shop or a country Academic science in the US is being gutted by Trump

This is no way to run a bagel shop or a country by Art Edison.
#NMRchat
artedison.substack.com/p/this-is-no...

Vaccine experts band together to counter U.S. government misinformation Vaccine Integrity Project intends to provide scientific responses to ill-founded vaccine moves

Vaccine scientists and medical leaders have announced they are launching an unprecedented initiative to react to vaccine misinformation and scientifically unfounded vaccine decisions by the U.S. government. scim.ag/3ES9r1Q

Nearly 800 NIH grants have been terminated so far, including some focused on HIV and AIDS, trans health, and COVID-19, after researchers were told their work was no longer an agency priority. https://cbsn.ws/3YkDndI

Rainy Saturday = bread baking. Made Cuban bread for the first time. #chemistswhocook

www.washingtonpost.com/health/2025/...

Trump Administration Has Begun a War on Science, Researchers Say (Gift Article) Nearly 2,000 scientists urged that Congress restore funding to federal agencies decimated by recent cuts.

On a letter I signed
www.nytimes.com/2025/03/31/s...

Igivearod 2025: Supporting Rural Alaska | DonorsChoose The Igivearod fundraising drive is a grassroots effort to support rural schools across Alaska and other community organizations along the route of the Iditarod Sled Dog Trail Race. Learn more at ig...

Thanks for posting this! What a great cause to support. #uglydogs I just supported Igivearod 2025: Supporting Rural Alaska on DonorsChoose. Help a classroom in need today. www.donorschoose.org/igivearod25?...

The #NMR event not to be missed in 2025!

Poster chair committee 2025 : Kathleen Farley, Amy Freund, Roberto Gil and Philippe Lesot
What a panel !

#NMRevents #NMRchat #NMR

Discovery of Nirmatrelvir (PF-07321332): A Potent, Orally Active Inhibitor of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV-2) Main Protease In early 2020, severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) infections leading to COVID-19 disease reached a global level leading to the World Health Organization (WHO) declaration of ...

Proud to be a member of this team! #NMRchat pubs.acs.org/doi/10.1021/...

Maybe you should do a cooking class? I would be interested.

"If you think research is expensive, try disease" - Mary Lasker

Nothing else to say.

Conformational Role of Methyl in the Potency of Cyclohexane-Substituted Squaramide CCR6 Antagonists CCR6 is a chemokine receptor that mediates the migration of pathogenic inflammatory leukocytes to sites of inflammation in response to its ligand, CCL20. Herein we report the design of a potent CCR6 antagonist capable of inhibiting the chemotactic migration of CCR6+ T cells in vitro. Key to this finding was the discovery of a remarkable methyl substituent effect on antagonist potency. A 365-fold improvement in potency was observed for the cis-2-methylcyclohexanamine analogue compared to the unsubstituted cyclohexanamine derivative. Evidence generated through the characterization of conformationally restricted analogues supports the conclusion that the large potency enhancement is the result of the methyl substituent biasing the cyclohexane ring ground state conformation to favor that of the bound ligand and thus decreasing the ligand strain energy.

A great example of the utility of NMR in drug discovery! Congratulations to the team! #NMRchat pubs.acs.org/doi/10.1021/...

Stand Up And Be Counted

Biopharma companies and CEOs are keeping their heads down at their own peril. They should speak up about what’s happening to the NIH and other science agencies before it’s too late.

Silence gives consent. And no one should consent to this.

It's not "Breaking News" now, since it was announced by NIH yesterday. But it is breaking.......
washingtonpost.com/health/2025/...

Picture of SMASH 2025 program chairs in Porto, Portugal

SMASH 2025 is in Porto, Portugal. #NMRchat #SMASH2025

Welcome to Bluesky!

RFK Jr. Is Not Up to the Enormous Task Before Him During his confirmation hearings, President Trump’s nominee to lead the Department of Health and Human Services showed that his dangerous views on vaccines and science haven’t changed.

🧪 About that "gold standard science" RFK is promising...and other takeaways from his two days in the hot seat. My latest @opinion.bloomberg.com (gift link):

Trump's NIH Freeze Puts Scientific Research at Risk America’s best scientific minds are scrambling to determine the impact of the disruption.

Some thoughts on the confusion and anxiety created by the current freeze on communications, hiring, grant reviews, travel, etc at NIH (gift link):

I do miss our morning chats and diagraming complex structural problems on the white board!

#retiredlife is great, how are things in 220?

Female scientist in front of NMR magnet

Sourdough bread

Siberian husky puppy

As an introduction to #bluesky
-I ❤️ big magnets #chemsky #nmrchat
-I just retired from #pfizer after 35+ years
-I am still active in NMR #SMASH @pubs.acs.org #MRC #JMedChem #consulting
-I ❤️ Sourdough! #chemistswhocook
-I ❤️ sled dogs #UglyDogs