Jörn Coers

Call for 20 Assistant Professor positions Karolinska Institutet is a world-leading medical university with a long and proud history of ground-breaking research. We are now recruiting outstanding early-career researchers with particularly exce...

Wow

Karolinska Institutet is recruiting 20 outstanding early-career researchers for assistant professor positions

ki.se/en/about-ki/...

Congrats to all the 2025 awardees including my colleague Ashley Moseman here at Duke

Great to see you relaunch your lab! Looking forward to learning about all the great things the Frickel lab 2.0 will discover

🔥 Open postdoc position in human inflammation-driven control of infection! 🔥
Join me at the University of Geneva, Switzerland this summer as I’m moving my Wellcome-funded research activity to the Department of Microbiology and Molecular Medicine! (1/5)

Please share!

The Human Genome Project cost taxpayers $3 Billion.

Two decades on, it has generated a staggering return on investment of $1 Trillion, with benefits in medicine, agriculture, energy, the environment, & more.

If you want to boost the economy, funding science is one of the best things you could do.

Excited to announce Duke’s inaugural Climate and Fungi Symposium May 16, 2025! Please register for in-person or virtual 🍄 mgm.duke.edu/about-mgm/se...

Thanks! - we're excited about it. Lots to discover moving forward on this project.

Human giant GTPase GVIN1 forms an antimicrobial coatomer around the intracellular bacterial pathogen Burkholderia thailandensis Several human pathogens exploit the kinetic forces generated by polymerizing actin to power their intracellular motility. Human cell-autonomous immune responses activated by the cytokine interferon-ga...

Exciting work from neighbor Jörn Coers at Duke identifying a new class of host defense GTPases. Out of a genetic screen they identify the human Giant GTPase GVIN1 (previously annotated as a human pseudogene) in coatomer-based restriction of Burkholderia motility. 1808 aas long!

Cathepsin Z is a conserved susceptibility factor underlying tuberculosis severity Tuberculosis (TB) outcomes vary widely, from asymptomatic infection to mortality, yet most animal models do not recapitulate human phenotypic and genotypic variation. The genetically diverse Collaborative Cross mouse panel models distinct facets of TB disease that occur in humans and allows identification of genomic loci underlying clinical outcomes. We previously mapped a TB susceptibility locus on mouse chromosome 2. Here, we identify cathepsin Z ( Ctsz ) as a lead candidate underlying this TB susceptibility and show that Ctsz ablation leads to increased bacterial burden, CXCL1 overproduction, and decreased survival in mice. Ctsz disturbance within murine macrophages enhances production of CXCL1, a known biomarker of TB severity. From a Ugandan household contact study, we identify significant associations between CTSZ variants and TB disease severity. Finally, we examine patient-derived TB granulomas and report CTSZ localization within granuloma-associated macrophages, placing human CTSZ at the host-pathogen interface. These findings implicate a conserved CTSZ-CXCL1 axis in humans and genetically diverse mice that mediates TB disease severity. ### Competing Interest Statement The authors have declared no competing interest.

New preprint from Clare Smith’s lab on Cathepsin Z as a TB host susceptibility locus - cool collaboration with Hawn and Stein labs @dukemedschool.bsky.social
www.biorxiv.org/content/10.1...

The Coers lab is now on bsky.