Kate Miroshnikova

Home from a great #EMBO workshop in Barcelona. Intracellular mechanics & organelle Mechanobiology was such a fun topic! @christanny.bsky.social made sure I didn’t get lost. It was great to catch up with @katemiro.bsky.social 1st time in almost 10yrs!!. Thank you to the hosts.. (continued) 1/2

24 Millionen Euro für zwei Sonderforschungsbereiche Die Deutsche Forschungsgemeinschaft richtet einen neuen Sonderforschungsbereich zur männlichen Unfruchtbarkeit ein und verlängert einen etablierten Verbund zu zellulären Grenzflächen. Insgesamt fließe...

Große Freude! Die @dfg.de richtet einen neuen Sonderforschungsbereich zur männlichen Unfruchtbarkeit ein und verlängert den etablierten Verbund @sfb1348.bsky.social. Insgesamt fließen rund 24 Millionen Euro an die Universität Münster.

Launching celldynamicslab.com, the homepage of our new group at EPFL working on cell fragmentation, membrane and cortex mechanics, FLIM imaging, and microfluidics tools. MSc/PhD or postdocs interested in quantitative cell biology are welcome to reach out. We're also hiring a lab manager in 2026!

Job Alert! The Institute for Neuro- and Behavioural Biology at the Faculty of Biology @uni-muenster.de invites applications for a Full Professorship (W3) in “Systems Neuroscience” - Highly attractive research environment at the Multiscale Imaging Center. Apply by January 5th. See shorturl.at/VczFp

Excited to embark on this scientific journey with Ewa Paluch and Daniel StJohnston to understand fundamentals of epithelial tissue and cell shapes! Thank you to @erc.europa.eu for the support!

Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities | Keystone Symposia Join us at the Keystone Symposia on Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities, March 2026, in Geneva, with field leaders!

Come join us in Geneva for everything epigenetics and gene regulation. It will be a great meeting! Please repost!
www.keystonesymposia.org/conferences/...

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

💫NEW: @sarawickstrom.bsky.social @katemiro.bsky.social & co show that mechano-osmotic changes in the #nucleus induce general #transcriptional repression and prime #chromatin for cell fate transitions by relieving repression of specific differentiation genes. #pluripotency
bit.ly/3VMcyNZ

Thanks Jesse!!!

Amazing to have our work finally out!!! 😍🤩😍

Amy, Leanne, Maria & Kate welcomed our #SCC25 attendees to the beautiful Malta this afternoon, a great 4 days ahead for this group, discussing all things Stem Cells & Cancer!
@joneslabucsf.bsky.social @mariapalcolea.bsky.social @katemiro.bsky.social

Happy to share the latest work from Preeti Sahu, with Adriana Sanchez-Danes on the biomechanics of cell fate choices during tumor initiation! We implement/test a 3D vertex model with proliferation and fate choices for multilayered tissues! See 🧵 below (1/n) bit.ly/3ZXxJzk

Paper accepted!!!!
Congratultions to @lizebonaaugust.bsky.social Blanca del Rosal and Leslie Yeo it was a pleasure to work together on this amazing project! 🎊🎊🎊🎊

How epithelial junctions mature: Study shows conformational transition in key protein Epithelial tissues cover the inner and outer surfaces of the body. A study by the working group of cell biologist Prof. Carsten Grashoff now provides insight into the molecular details underlying the ...

Exciting new paper by the group of Carsten Grashoff @sfb1348.bsky.social @uni-muenster.de
shows conformational change in alpha-Catenin during maturation of #epithelial junctions
www.uni-muenster.de/news/view.ph...

Computational image analyst (m/f/d) The Max Planck Institute for Molecular Biomedicine in Münster, Germany, has an opening for a

My lab @mpi-muenster.bsky.social is looking for a computational biologist with a passion for imaging and spatial biology. A staff scientist position with long-term perspective! Apply and spread the word 🙏 jobs.mpi-muenster.mpg.de/jobposting/0...

Job add showing the lab logo and the following text: WHAT WE OFFER Fully-funded fellowships up to five years Opportunity to start your own research program or lead ongoing projects. Large, diverse and extraordinary scientific network at the NIH/Bethesda campus. Working at NIH offers the possibility of living in a diverse, liberal and vibrant city: Washington DC Or in a calm residential area with great schools and good affordable housing: Bethesda and Rockville. WHO YOU ARE You share our enthusiasm for epigenetics, gene regulation, nuclear organization and mouse development. You have PhD-experience in one or more of the following: mouse development, mouse genetics, epigenetics, or computational biology.

🚨🚨🚨 Please repost
We are looking for postdocs to join our lab at NIH.
Apply:
www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply
Learn more about training at NIH :
www.training.nih.gov/research-tra...

DNA methylation influences human centromere positioning and function - Nature Genetics Genome-wide and targeted perturbation of DNA methylation at centromeres affects CENP-A positioning and centromere structure, resulting in aneuploidy and reduced cell viability.

▶️ Pour en savoir plus
⏩ Lire l'actu : curie.fr/actualite/di...
⏩ Lire la publication : www.nature.com/articles/s41...

Would love to be a part of the group if still space! Thanks!

New preprint! 🚨 We uncover a slow adaptation to stretch that links star-bundling of keratin filaments with nuclear escape from its keratin cage. Led by @tomgolde.bsky.social‬ 🙌
@IBECBarcelona
www.biorxiv.org/content/10.1...

Final call to register and submit abstracts for the @faseborg.bsky.social conference on the Mechanobiology of the Cell Nucleus (#MBNSRC) to be considered for platform presentations. The conference takes place in Melbourne, FL, Oct. 26-30, 2025. See more info at: events.faseb.org/event/Mechan...

Thanks so much for the kind words Adrien! 🤩 would love to discuss the next steps to integrate more mechanical measurements as planned soon!

Pathologists have used nuclear & tissue shapes to diagnose #cancer for decades, but what is the molecular basis for this? In our latest work, we develop a computational pipeline to figure this out in #colorectalcancer! Check out 🧵& preprint #mechanobiology #stemcells www.biorxiv.org/content/10.1...

Thanks so much Martin, hope all is well - would love your feedback!

a woman with a big hairdo is singing and the words simply the best are above her ALT: a woman with a big hairdo is singing and the words simply the best are above her

Very proud of this work performed by the super talented Fabien Bertillot with essential support from @sol-herve.bsky.social and our amazing collaborators, especially Toni Seppälä and @sarawickstrom.bsky.social. Grateful for support from @mpi-muenster.bsky.social, NIH, and @helsinki.fi

Collectively, our work supports a model where disruption of tissue architecture & stromal cues initiate a co-evolutionary feed forward loop that drives disease aggression & suggests that quantitative analysis of tumor heterogeneity with architecture as proxy may be the key to diagnostic precision

Interestingly, while epithelial-to-mesenchymal transition states were also enriched in fragmented architectures, mechanical confinement was not sufficient to trigger #EMT. Combination of compression & soluble signals from the stroma drove further separation of regenerative stem cell and EMT states.

To figure out causation we turned to patient derived #organoids. Together with our #bioengineering colleagues in the Lutolf lab we generated topographies that mimic poor prognosis architectures. Indeed, regenerative stem cell states emerged in response to mechanical constraints and compression

Analyzing single patient biopsies with heterogeneous architectures showed that cell states and architectures co-evolve, and we can predict likely tissue shape transitions based on the transcriptional signatures! So now the chicken & egg question: which comes first – abnormal shapes or cell states?

Intriguingly, nuclear shapes correspond with tissue architectures, both independently predicting patient survival. Overlaying this with #spatialtranscriptomics revealed that fragmented architectures associate with regenerative stem cell states that have been shown to drive metastasis.

Pathologists have used nuclear & tissue shapes to diagnose #cancer for decades, but what is the molecular basis for this? In our latest work, we develop a computational pipeline to figure this out in #colorectalcancer! Check out 🧵& preprint #mechanobiology #stemcells www.biorxiv.org/content/10.1...

A Nuclear Mechanobiology meeting is a dream come true!!! Please join us!