Rupert Beale

Carbonara.

@southlondongirl.bsky.social right so I don’t recommend swimming with your iPhone in your pocket. Long story, also boring. But Sicily, excellent, @flossieteacake.bsky.social said I should share this pasta alla Norma with you. It’s got Ricotta Salata and everything. Aces. Shall we do dinner sometime?

No it's normal.

Congrats, very interesting work!

The main thing - is it not already clear - RFKr Jr is uniquely unqualified to lead the HHS.

All main agencies under his watch - NIH, FDA, CMS - are also headed by incompetent contrarian peddlers of disinformation, conspiracy theories, and pseudoscience.

This will, and already does, cost lives.

Notes from Beethoven’s genome Wesseldijk et al. compare the genomic information collected from Ludwig van Beethoven with population-based datasets used to quantify musical achievement.

If someone you know buys into claims about "genetic optimization" of embryos using polygenic scores of cognition, just send them our 2024 paper on Beethoven & musicality. We wrote it to help communicate limits of individual-level genetic predictions & complexity of links between DNA & behaviour. 🧪👇

I know we're supposed to reflexively dismiss the loss of any niche subject in the humanities, but this is a big part of why the university exists: so a student who wants to learn Basque can learn Basque. & the reason a school can offer that class is because THEY HAVE A ROMANCE LANGUAGES DEPARTMENT.

Surely you meant to write ‘formerly a world class institution’?

🎥 The Keystone Symposium on Autophagosomes & Endolysosomes is now on demand!

Watch talks on lysosome‑mediated quality control, nutrient regulation & cell signaling—insights from leaders in the field
.
👉 keysym.us/KSAutophagy2...
#KSAutophagy25 #autophagosome #endolysosomes @bealelab.bsky.social

Not necessarily anything very much to do with heart function.

The Autophagosomes & Endolysosomes meeting wraps today in Whistler, capping days of deep insight into lysosomal biology & autophagy.

👏 Congrats to our Keystone scholarship awardees—your future in science is bright!
🔗 keysym.us/scholarships...
#KSAutophagy25 @bealelab.bsky.social

Cheering myself up by reminding myself this is happening next week.

Congrats, very interesting paper.

DMXL1 promotes recruitment of V1-ATPase to lysosomes upon TRPML1 activation - Nature Structural & Molecular Biology Lee et al. show that DMXL1, a regulator of V-ATPase assembly, is recruited to lysosomes upon TRPML1 activation in a manner dependent on conjugation of ATG8 proteins on lysosomal membranes (CASM) and p...

Chan Lee @harperlabhms.bsky.social reports CASM-driven V-ATPase recruitment to lysosomes for acidification upon TRPML1 activation via DMXL1-RAVE loader. With Magdalene Moran(Caraway), Sophie Helaine lab, Joao Paulo, & HarperLab teams(HMS). Funds: Warren Alpert FND/NIH www.nature.com/articles/s41...

MPs have personal beliefs, but also solemn duties: that’s why they must reject the assisted dying bill this week | Gordon Brown Our obligations to each other are ill served if laws focus unduly on those who want assisted dying. The priority should be the best palliative care, says former prime minister Gordon Brown

Sharing this on the eve of tomorrow's vote.

I am a palliative care doctor who is not opposed to AD. But enshrining in law a state-funded right to die, while not enshrine a similar right to the palliative care that might make life worth living, is so very wrong.

www.theguardian.com/commentisfre...

RFK Jr. removes all members of CDC panel advising U.S. on vaccines It's the latest move by Kennedy – a prominent vaccine skeptic – to change and potentially undermine vaccinations in the U.S. since he took the helm at HHS.

Robert F Kennedy Jr said he is “retiring” all 17 members of a crucial government panel of vaccine advisors

He is removing all members of the Advisory Committee on Immunization Practices, which advises the CDC and Prevention

This could serious damage US health
www.cnbc.com/2025/06/09/r...

‘Deficiencies in protecting patients and professionals’ - RCP publishes its position on the Terminally Ill Adults (End of Life) Bill

We have raised concerns about existing deficiencies in the Terminally Ill Adults (End of Life) Bill.

We believe the bill in its current form lacks adequate protections for patients and professionals.

Full statement: ow.ly/EOhP50W692q

Mrs Beale trying to persuade me to come to your book event… apologies!

Yep.

😜

🤔

Today it’s TOMOPORK. With seven vegetables, because Pentecost.

Well this wasn’t at all 100% predictable.

Pasta alla Norma! @flossieteacake.bsky.social wanted it.

Wellington!

Waitrose would have a lot to answer for if so…

These were non poisonous…. I hope!

I do like clafoutis.

None of us really have a sweet tooth, so I’m not much of a pastry chef.

Well there’s cheese and cherries a lemon tart (that I didn’t make). But nobody needs more food!