Changing Gastrointestinal Transit Time Alters Microbiome Composition and Bile Acid Metabolism: A Cross‐Over Study in Healthy Volunteers Alterations in whole gut transit time (WGTT) significantly impact microbiome composition and bile acid metabolism. Using senna and loperamide, we show that WGTT changes influence bacterial diversity,....

doi.org/10.1111/nmo....
We show lower transit time alone decreases microbiome diversity + BA metabolism and increases fecal BA. Many 'omics studies and breath testing (SIBO) don't take this into account, hindering true progress on IBS/IBD pathomechanism.
#gastrosky #MedSky

25.05.2025 11:39 — 👍 3    🔁 1    💬 0    📌 0

Looking forward to present my talk about "Epimerization of Host-Derived Bile Acids By Ruminococcus gnavus
as a Hallmark of Microbiota Dysbiosis" at #KSHumanMicro25 #KSHostMicrobe25

Connecting bacteria to specific metabolites, will enhance out mechanistic understanding of IBD.
#gastrosky #MedSky

16.02.2025 18:51 — 👍 2    🔁 0    💬 0    📌 0

BS and UC have endoscopically visible mucosal biofilms that represent a disrupted microbiome and Bile acid malabsorption as possible mechanism of diarrhea.

www.gastrojournal.org/article/S001...

#gastrosky #MedSky
@gastroenterology.bsky.social

16.02.2025 18:41 — 👍 2    🔁 0    💬 0    📌 0