Ribosomes On the Road: Neurons Assemble Protein Factories Far from the Nucleus New study shows ribosome biogenesis can occur within neuronal branches, challenging traditional textbook biology.

🚛 Ribosomes on the road! New research from the Schuman Lab @mpibrain.bsky.social shows neurons can locally assemble ribosomes - far from the nucleus and close to synapses. A big shift from textbook biology! 📚🧬🔗 bit.ly/3GUJKPv #Neuroscience #CellBiology #Ribosomes

Novel dopaminergic neurotransmission in the Octopus visual system Coleoid cephalopods such as the common octopus have a complex visual system, with a camera-type eye and a large optic lobe, that evolved independently from its counterpart in vertebrates. However, the...

Very excited and proud to finally share this story! 🐙

We discovered surprising roles for dopamine and acetylcholine in the Octopus visual system…
doi.org/10.1101/2025...

Today we report the directed evolution of HUH into rHUH, a sequence-specific covalent protein tag for RNA labeling. rHUH was hard to engineer: the initial HUH template had no RNA activity, so we started with RNA-DNA hybrids. 30 rounds of selection on the yeast surface were required, and 7 cycles of

Erin M. Schuman Wins 2026 Nakasone Award

🎉 Huge congratulations to @MpiBrain director Erin Schuman @erin-schuman.bsky.social on receiving the 2026 Nakasone Award for her groundbreaking work on the function and plasticity of neuronal synapses! 🧠 @hfspo.bsky.social ‬#neuroscience #HFSP #NakasoneAward 👉 bit.ly/4m6g40P

Optogenetic storage and release of protein and mRNA in live cells and animals - Nature Communications Spatiotemporal control of biomolecules is a key challenge in cell biology. Here, authors introduce RELISR, an optogenetic condensate system enabling reversible, light-dependent sequestration and relea...

Optogenetic storage and release of protein and mRNA in live cells and animals | Nature Communications share.google/gz8nYXZ3hUVh...

#spatialbiology #imagingtools #fluorescencemicroscopy

🚀 We’re thrilled to welcome 14 talented and enthusiastic high-school students to the 2025 Max Planck Junior Scholars Program, kicking off today with a Science Boot Camp Week @mpibrain.bsky.social ! 🔬🧬 @maxplanck.de

Optogenetic storage and release of protein and mRNA in live cells and animals @natcomms.nature.com
www.nature.com/articles/s41...

119 EMBO Fellows from 30+ countries attended the EMBO Fellows’ Meeting in Heidelberg, DE from 27 June–1 July. #Research was shared and connections formed – an incredible opportunity for #networking and #collaboration. Thank you to all who joined and were part of this vibrant community! 🧪

Out now! We found a new molecule, OSP-1, that protects neurons from damage caused by oxidative stress. We show that OSP-1 reduces cell death by regulating autophagy, and can be an exciting target for future treatments of acute insults such as stroke.

www.nature.com/articles/s41...

This paper is now featured by @naturecomms.bsky.social on their Editors' Highlights page
Check it out 👇
www.nature.com/collections/...

NEW Paper:
If you're a fan of Rachel from 'Friends', you would love OSP-1, as it is also protective of ROS

Donato et al. found a novel gene OSP-1 (oxidative stress protective 1) that protects neurons from damage caused by reactive oxygen species (ROS), by modulating autophagy.👇

OSP-1 protects neurons from autophagic cell death induced by acute oxidative stress - Nature Communications How oxidative stress impacts neurons is poorly understood. Here the authors reveal that overactivation of autophagy following oxidative stress contributes to neuronal death and discover a protective f...

Leveraging the genetic power of the nematode C. elegans and the optogenetic tool KillerRed, the Hilliard Lab discovered osp-1, a novel gene that protects neurons from oxidative damage via cell-autonomous mechanisms 🧠 doi.org/10.1038/s414...

Upconverting microgauges reveal intraluminal force dynamics in vivo Nature - Nanoparticle-based ‘microgauges’ are developed for in vivo force sensing and deployed in C. elegans to investigate how mechanical force correlates with electrical signalling in...

How hard do bacteria-eating nematodes bite in order to break the bacterial cell wall? Check out our new paper, led by Jason Casar & collab with Jen Dionne, using pressure sensing beads that change color upon compression (bluetorial coming soon) rdcu.be/d5n7v

P-stalk ribosomes act as master regulators of cytokine-mediated processes Cytokines remodel the ribosome to incorporate the P-stalk, therefore altering the translation of mRNAs involved in cytokine responses.

New paper from the Faller Lab on P-stalk ribosomes and cytokine responses and commentary from the Willis Lab. #RNABiology #Ribosome
www.cell.com/cell/fulltex...

I am super excited to share our article addressing a longstanding question in neurobiology: how Ca²⁺ signaling cascades initiated at dendritic spines operate at a distance. Check it out here: authors.elsevier.com/sd/article/S... @cp-cell.bsky.social.

The Roger Evans and Aey Phanachet Stipendiary Research Fellowship: Symbiosis and/or Co-Evolution

Are you looking for postdoc opportunities? This @kingscollege.bsky.social research fellowship could be a fantastic opportunity for C. elegans research, if you're interested please do get in touch!
www.kings.cam.ac.uk/about/work-a...