WredenbergLab

Methylation is essential not only for RNA stability — we show it’s structurally required for forming the peptidyl transferase center (PTC). Without it, the mitoribosome stalls at an immature stage, unable to build its catalytic core.

By depleting mitochondria of S-adenosylmethionine (SAM), we disrupt canonical rRNA processing at the ribosomal junctions in MEFs and skeletal muscle. This leads to accumulation of unprocessed transcripts and defective ribosome assembly.

The mitochondrial methylation potential gates mitoribosome assembly Nature Communications - Here, using long-read RNA sequencing, SILAC proteomics, and cryo-EM, the authors show that loss of mitochondrial methylation impairs rRNA processing and ribosome maturation,...

Excited to share our latest work on how mitochondrial methylation shapes gene expression. Using long-read RNAseq and cryo-EM, we uncover two methylation-dependent checkpoints in ribosome biogenesis.
Thanks to everyone invovled. @ruthicglasgow.bsky.social @amunts.bsky.social
🔗 rdcu.be/etk12

Postdoctoral fellowship (2 years) to study mitochondrial DNA stability

Hello fellow mitochondriacs! Are you passionate about mtDNA? We now offer a 2-year postdoc opportunity for studies of mtDNA instability and its signaling. Apply by May 18th to join our international team in exotic Umeå. Please share!
www.umu.se/en/work-with...

Coupling of ribosome biogenesis and translation initiation in human mitochondria - Nature Communications Mitochondrial ribosome biogenesis requires the assistance of multiple assembly factors. Here, the authors provide insights into the essential role of the GTPase MTG3 during small subunit biogenesis an...

Happy to share out latest collaborative work with the groups of Ricarda Richter-Dennerlein and Peter Rehling just out in
@natcomms.nature.com. Great work led by two very talented PhD students - Franziska Finke (our lab) and Marleen Heinrichs (Richter-Dennerlein lab).
www.nature.com/articles/s41...

Small molecules restore mutant mitochondrial DNA polymerase activity - Nature An activator of DNA polymerase γ restores function to disease-causing mutant variants and demonstrates a potential route to treatments for inherited mitochondrial disorders involving POLG mutations.

New paper out from the Falkenberg and Gustafsson labs. Thanks to Pretzel for a successful collaboration.
www.nature.com/articles/s41...

Doktorandplats inom mitokondriell metabolism Vill du bidra till medicinsk forskning av toppkvalitet? Att vara doktorand innebär att vara antagen till en utbildning på forskarnivå (forskarutbildning) där man följer en individuell studieplan.

Interested in mitochondrial biology? We are looking for an enthusiastic PostDoctoral fellow and PhD student to join our group in Stockholm.
For the PhD position: kidoktorand.varbi.com/what:job/job...
For the PostDoc position: ki.varbi.com/what:job/job...

We argued that since mtDNA mutation accumulation is progressive, cellular mechanisms must influence its pathogenicity. Through a genetic screen in fruit flies, we identified pathways that can rescue a lethal mtDNA mutator phenotype. We are excited to test this in higher species.

Preventing excessive autophagy protects from the pathology of mtDNA mutations in Drosophila melanogaster - Nature Communications Finding ways to compensate for mitochondrial dysfunction is essential. Here, the authors performed a genome-wide genetic screen to identify genes that mitigate the larvae lethal phenotype of a fruit f...

We are excited to share our latest work on mechanisms that protect from mitochondrial dysfunction. Thank you to all collaborators and the 4th anonymous reviewer for supporting us. @naturecomms.bsky.social
www.nature.com/articles/s41...

1-2 Postdoctoral researchers in mitochondrial biology (scholarship) Do you want to contribute to improving human health? Research at the Division of Molecular Metabolism aims to understand the regulation of mitochondrial function and the role of mitochondrial dysfunct

We are hiring. Looking for a PostDoc in mitochondrial biology? We are offering an excellent scientific environment at the Division of Molecular Metabolism. Apply here:
ki.varbi.com/ny/what:job/...