Guillaume Charras

How does signalling control cortical tension?

Using optogenetics and AFM, we show that myosin recruitment and cortical tension increase proportionally with RhoA signalling.

More here:
www.biorxiv.org/content/10.6...

Super work by Pierre Bohec with Guillaume Salbreux and @dianakhorom.bsky.social

Structure and Function of the Cytoskeleton The cytoskeleton, a dynamic and intricate network of protein filaments, is found within the cytoplasm of all cells, from bacteria and archaea to complex eukaryotes. This essential cellular component …

Learn all things #cytoskeleton #research in an interdisciplinary environment at EMBO Workshop "Structure and Function of the Cytoskeleton" in Paris, FR, 7–10 April 2026.

Deadline: 20 December 2025

https://meetings.embo.org/event/26-cytoskeleton
#EMBOCytoskeletalFunction #EMBOevents #conference 🧪

Robust pan-junctional reinforcement preserves the gut epithelial barrier under mechanical stress Epithelia are specialized tissue barriers that safeguard the organism's internal milieu from the hostile external environment, a function critically dependent on intercellular junctions. In the colon,...

Ever wondered how adult organs preserve epithelial barrier integrity while continuously exposed to mechanical stress? We tackled this question in our new preprint – led by our brilliant PhD student Vishnu Krishnakumar! (1/11)
🔗 www.biorxiv.org/content/10.1...

Can pressure gradients persist over long timescales in animal cells? We induced intracellular pressure gradients and examined the resulting flows in single cells. We reveal surprisingly long lasting pressure gradients.

More here: elifesciences.org/reviewed-pre...

🥳 Thrilled to share our lab's first preprint, led by our talented postdoc Justine Creff! 👩🏻‍🔬 We tackled a fundamental question: how the epithelium withstands mechanical stress at the interface of cells with distinct geometries and mechanics, such as enterocytes (E) and goblet cells (G) (1/9)

👋 Are you looking for a postdoc position? Do you think microtubules are fascinating? Then we might have the job for you! 2-year funded postdoc to join our lab!
👉 deadline 20/06
👇 check it out

www.godinholab.com

Spatial and temporal signatures of cell competition revealed by K-function analysis | Molecular Biology of the Cell Cell competition is often categorized into mechanical competition, during which loser cell elimination is induced by long-range mechanical effects, and biochemical competition, during which loser cell...

Very happy to see my PhD work published and featured as the cover of MBoC. Thanks to Jasmine, Manasi, Giulia and of course Guillaume @gcharras.bsky.social and Alan @quantumjot.bsky.social for all the support! doi.org/10.1091/mbc....