Dominic Grün

Major new direction in the lab: hacking human cell biology with pathogen effectors (eORFs) - amazing collaboration with @miketilapia.bsky.social lab. Huge congrats to first authors Tomas & He & all co-authors! Check out the pre-print on @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...

Spatiotemporal dynamics of the cardioimmune niche during lesion repair - Nature Cardiovascular Research Chan et al. generate a high-resolution spatiotemporal atlas of healing hearts and reveal cellular networks of lesion repair, including macrophage–fibroblast interactions that control late-stage fibros...

Research | Chan et al. generate a high-resolution spatiotemporal atlas of healing hearts and reveal cellular networks of lesion repair, including macrophage-fibroblast interactions that control late-stage fibrosis.

doi.org/10.1038/s441...
rdcu.be/ePzs6

Highly cited Würzburg researchers (clockwise): Ronny Thomale, José Pedro Friedmann Angeli, Georg Gasteiger, Dominic Grün, and Christoph Wanner. (Image: Tobias Ritz / José Pedro Friedmann Angeli / Katja Krause / Marcus Rockoff / Daniel Peter)

We are delighted to announce our #HighlyCited2025 researchers: Ronny Thomale, @angelifriedmann.bsky.social , Georg Gasteiger, @dominicgrun.bsky.social, and Christoph Wanner. Congratulations!
➡️ www.uni-wuerzburg.de/en/news-and-...

Thanks, Gennady! If you email me, I can connect you with Andy who performed the data analysis.

Thanks, Kilian!

This massive project was led by my excellent postdoc @andysonchan.bsky.social.
This work would not have been possible without all our fantastic collaborators, in particular, the groups of Peter Kohl and Franziska Schneider-Warme who provided essential experimental in vivo methods.

Our data provide a rich basis for the identification of molecular targets for novel therapeutic approaches to improve heart healing after myocardial infarction.

Unexpectedly, our data reveal a rare population of progenitor-like cardiomyocytes that up-regulate proliferation gene programs. NiCo predicted rare immune cells (ILC2) together with myeloid and endothelial cells as synergistic inducers of dedifferentiation via BMP7, TWEAK, and IL1B signalling.

Based on NiCo’s covariation analysis, we predict signalling pathways mediating mutual suppression of proliferation between myofibroblasts and macrophages that could be an essential molecular break limiting excessive scar formation. We provide extensive in vitro validation of these pathways.

Using our published NiCo algorithm, we infer cellular niche networks and molecular drivers of cell state dynamics. In particular, we predict and validate signalling pathways that control cell state changes of monocytes into pro-inflammatory and subsequently into immune-regulatory macrophages.

We dissected dynamics of cellular states across all cell populations, including rare cell types underrepresented in available resources. In particular, we resolve dynamics of a broad spectrum of immune cell types.

We generated a large resource of single-cell transcriptome and single-cell resolution spatial transcriptomics (Xenium) data for two common models of cardiac repair (cryoinjury and LAD). We demonstrate very similar responses in both models.

Our spatio-temporal map of lesion repair in the heart at single-cell resolution is now published in @natureportfolio.nature.com Cardiovascular Research.
www.nature.com/articles/s44...
We dissected dynamics of multicellular niches that control cardiac repair. See 🧵 for highlights.

The Roadmap of the Human Liver Cell Atlas is out in @natrevgastrohep.nature.com laying out the scope and goals of our Human Liver Cell Atlas emerging from the @cziscience.bsky.social funded Liver Seed Network.
www.nature.com/articles/s41...

** Now seeking postdocs **

Join our interdisciplinary and transnational team in Würzburg (Germany) or Paris (France) to drive projects in translational biology and antibiotic drug discovery.
Backgrounds in computational biology, AI, physics, or microbiology are all welcome. Please spread the word.

Registration for our "Advances in Single-Cell Technologies" meeting is still open and we invite abstract submissions until October 30th. Join us in beautiful Freiburg together with an excellent line-up of single-cell technology experts!
www.uniklinik-freiburg.de/single-cell-...

Join our "Advances in Single-Cell Technologies" meeting in December in Freiburg, co-organised with Marco Prinz and @katrinkierdorf.bsky.social. Excellent line-up of speakers covering spatial technologies, lineage tracing, computational methods, and more.
www.uniklinik-freiburg.de/single-cell-...

New preprint from the lab! Using multiplexed spatial analysis and single-cell multiomics, we resolved the portal liver immune niche and identified crosstalk between cholangiocytes, dendritic cells and gdT cells that controls fibrosis in a mouse cholangitis model.
www.biorxiv.org/content/10.1...

Join us for a series of presentations from leading data science experts, including @francescafinotello.bsky.social, @dominicgrun.bsky.social, Johanna Klughammer, Malte Lücken, @fabiantheis.bsky.social and @jwrth.genomic.social.ap.brid.gy.

Few dates left to apply for this tenure-track professorship on Single-Cell Systems Biology in my department at @uni-wuerzburg.de. Competitive package and highly attractive research environment at the Institute of Systems Immunology.

Consider attending the MOPITAS autumn school on Spatial Transcriptomics in Munich with expert lectures and hands-on sessions for all steps of spatial transcriptomics data analysis.
event.sdu.dk/mopitas-scho...

junior professorship position (f/m/d) in Single-Cell Systems Biology - Würzburg (Stadt), Bayern (DE) job with Julius-Maximilians-University Würzburg - Faculty of Medicine | 673667 The Julius-Maximilians-University Würzburg, Faculty of Medicine is offering one junior professorship position (f/m/d) in Single-Cell Systems Biology.

We have an attractive opening for a tenure-track professorship in Single-Cell Systems Biology. Excellent package and infrastructure at @uni-wuerzburg.de Institute of Systems Immunology. Great place to live and work in the heart of the franconian wine region!

jobs.sciencecareers.org/job/673667/j...

LoxCode in vivo barcoding reveals epiblast clonal fate bias to fetal organs Much remains to be learned about the clonal fate of mammalian epiblast cells. Here, we develop high-diversity Cre recombinase-driven LoxCode barcoding…

A triumph of perseverance from twitterless Tom Weber, Christine Biben and the team, our in vivo barcoding "LoxCode mouse" used to resolve epiblast fate to fetal organs is finally published in @cellpress.bsky.social and available through @jacksonlab.bsky.social www.sciencedirect.com/science/arti...

Congrats, Shalin and team! Really looking forward to read this!

Registration for the upcoming symposium "Imaging the Immune System VI" in Würzburg is still open. Fantastic speaker line-up at a beautiful historic venue in the centre of Würzburg.

imaging-immune-system.wuesi.com

Barry Blitt’s cover for this week’s issue, “The First Hundred Days.” #NewYorkerCovers nyer.cm/ysrCZ47

Congrats Nina and team!! Great to see this beautiful study published!

Extremely happy to share our study on the regulation of HSCs in the context of myocardial infarction published in Nature Cell Biology! Driven by two amazing scientists in my lab - Jasmin and Maricarmen and co-led with the awesome cardiologist Timo! Huge thanks also to all our collaborators 👏🏻👏🏻

Segger logo

Message passing intuition behind the segger’s link-prediction model and the network architecture

1/ New preprint! 🍳

@elihei.bsky.social and our team at @embl.org , @dkfz.bsky.social, and @mskcancercenter.bsky.social built #segger - a fast, accurate cell segmentation tool for spatial transcriptomics that assigns transcripts to their cell origins!

doi.org/10.1101/2025...

Research Assistant in the field of glioblastoma immunology Do you want to contribute to top quality medical research? The Sten Linnarsson lab is a part of Unit of Molecular Neurobiology at the Department of Medical Biochemistry and Biophysics (MBB) . Linnarss

We're looking to hire a research assistant for flow cytometry of brain tumor immune cells! Apply here -> ki.varbi.com/en/what:job/...