Dominic Grün

The Roadmap of the Human Liver Cell Atlas is out in @natrevgastrohep.nature.com laying out the scope and goals of our Human Liver Cell Atlas emerging from the @cziscience.bsky.social funded Liver Seed Network.
www.nature.com/articles/s41...

** Now seeking postdocs **

Join our interdisciplinary and transnational team in Würzburg (Germany) or Paris (France) to drive projects in translational biology and antibiotic drug discovery.
Backgrounds in computational biology, AI, physics, or microbiology are all welcome. Please spread the word.

Registration for our "Advances in Single-Cell Technologies" meeting is still open and we invite abstract submissions until October 30th. Join us in beautiful Freiburg together with an excellent line-up of single-cell technology experts!
www.uniklinik-freiburg.de/single-cell-...

Join our "Advances in Single-Cell Technologies" meeting in December in Freiburg, co-organised with Marco Prinz and @katrinkierdorf.bsky.social. Excellent line-up of speakers covering spatial technologies, lineage tracing, computational methods, and more.
www.uniklinik-freiburg.de/single-cell-...

New preprint from the lab! Using multiplexed spatial analysis and single-cell multiomics, we resolved the portal liver immune niche and identified crosstalk between cholangiocytes, dendritic cells and gdT cells that controls fibrosis in a mouse cholangitis model.
www.biorxiv.org/content/10.1...

Join us for a series of presentations from leading data science experts, including @francescafinotello.bsky.social, @dominicgrun.bsky.social, Johanna Klughammer, Malte Lücken, @fabiantheis.bsky.social and @jwrth.genomic.social.ap.brid.gy.

Few dates left to apply for this tenure-track professorship on Single-Cell Systems Biology in my department at @uni-wuerzburg.de. Competitive package and highly attractive research environment at the Institute of Systems Immunology.

Consider attending the MOPITAS autumn school on Spatial Transcriptomics in Munich with expert lectures and hands-on sessions for all steps of spatial transcriptomics data analysis.
event.sdu.dk/mopitas-scho...

junior professorship position (f/m/d) in Single-Cell Systems Biology - Würzburg (Stadt), Bayern (DE) job with Julius-Maximilians-University Würzburg - Faculty of Medicine | 673667 The Julius-Maximilians-University Würzburg, Faculty of Medicine is offering one junior professorship position (f/m/d) in Single-Cell Systems Biology.

We have an attractive opening for a tenure-track professorship in Single-Cell Systems Biology. Excellent package and infrastructure at @uni-wuerzburg.de Institute of Systems Immunology. Great place to live and work in the heart of the franconian wine region!

jobs.sciencecareers.org/job/673667/j...

LoxCode in vivo barcoding reveals epiblast clonal fate bias to fetal organs Much remains to be learned about the clonal fate of mammalian epiblast cells. Here, we develop high-diversity Cre recombinase-driven LoxCode barcoding…

A triumph of perseverance from twitterless Tom Weber, Christine Biben and the team, our in vivo barcoding "LoxCode mouse" used to resolve epiblast fate to fetal organs is finally published in @cellpress.bsky.social and available through @jacksonlab.bsky.social www.sciencedirect.com/science/arti...

Congrats, Shalin and team! Really looking forward to read this!

Registration for the upcoming symposium "Imaging the Immune System VI" in Würzburg is still open. Fantastic speaker line-up at a beautiful historic venue in the centre of Würzburg.

imaging-immune-system.wuesi.com

Barry Blitt’s cover for this week’s issue, “The First Hundred Days.” #NewYorkerCovers nyer.cm/ysrCZ47

Congrats Nina and team!! Great to see this beautiful study published!

Extremely happy to share our study on the regulation of HSCs in the context of myocardial infarction published in Nature Cell Biology! Driven by two amazing scientists in my lab - Jasmin and Maricarmen and co-led with the awesome cardiologist Timo! Huge thanks also to all our collaborators 👏🏻👏🏻

Segger logo

Message passing intuition behind the segger’s link-prediction model and the network architecture

1/ New preprint! 🍳

@elihei.bsky.social and our team at @embl.org , @dkfz.bsky.social, and @mskcancercenter.bsky.social built #segger - a fast, accurate cell segmentation tool for spatial transcriptomics that assigns transcripts to their cell origins!

doi.org/10.1101/2025...

Research Assistant in the field of glioblastoma immunology Do you want to contribute to top quality medical research? The Sten Linnarsson lab is a part of Unit of Molecular Neurobiology at the Department of Medical Biochemistry and Biophysics (MBB) . Linnarss

We're looking to hire a research assistant for flow cytometry of brain tumor immune cells! Apply here -> ki.varbi.com/en/what:job/...

Postdoctoral fellow - Saez-Rodriguez Group Your group Saez-Rodriguez Research Group Your supervisor Julio Saez-Rodriguez Your role As a postdoctoral fellow in the Saez Rodriguez group, you will develop and apply computational methods and tools...

6 days left to apply to the Post-doc opening in our lab
@ebi.embl.org to develop&apply #bioinformatics & #machine-learning methods to study intra-/extra cellular networks to extract disease mechanisms from #single-cell and #spatial multiomic data: embl.wd103.myworkdayjobs.com/EMBL/job/Hin...

This is my institution. These are the people I work with making these decisions. The situation is heartbreaking. Public medical schools have no other choice; there is no other source of funding, and everyone in academia is at extreme risk right now.

Currently, there's a lot of interest in quantitative models that would help us understand and predict features of the complex cellular systems that underlie human health and disease - think about virtual cells, for example. On can trace some of these ideas back to the early days of systems biology.

Office desk without any personal items or decor

Today, along with 2,000 other NIH employees, I had to clear out my office 😭

It was truly the honor of my life to work with such incredibly passionate people focused on improving human health. I’ve never experienced a more positive culture where *everyone* cared about their job and serving others.

Decoding cell–cell communication using spatial transcriptomics Nature Reviews Genetics, Published online: 21 February 2025; doi:10.1038/s41576-025-00824-3In this Tools of the Trade article, Ankit Agrawal introduces the computational framework NiCo (Niche Covariation), which integrates spatial transcriptomics with…

New online! Decoding cell–cell communication using spatial transcriptomics

Decoding cell–cell communication using spatial transcriptomics - Nature Reviews Genetics In this Tools of the Trade article, Ankit Agrawal introduces the computational framework NiCo (Niche Covariation), which integrates spatial transcriptomics with single-cell RNA-sequencing data to stud...

Check out this nice "Tools of the Trade" piece in Nature Reviews Genetics written by Ankit Agrawal on our NiCo algorithm for the analysis of single-cell spatial transcriptomics data from platforms like Xenium, MERSCOPE, seqFISH etc.
Feel free to reach out for advice.
www.nature.com/articles/s41...

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.

Mapping cells through time and space with moscot - Nature Moscot is an optimal transport approach that overcomes current limitations of similar methods to enable multimodal, scalable and consistent single-cell analyses of datasets across spatial and temporal...

Excited to see Moscot (moscot-tools.org) published in @Nature! We scaled Optimal Transport (OT) in single-cell genomics & added multimodality together with spatiotemporal trajectory inference, finding exciting new biology in the pancreas! 🚀 Read at www.nature.com/articles/s41...

That looks super interesting…

Our new lab coffee machine. What a beauty…

DESeq2 has 74k citations! Crazy 🤩

A few days left to apply if you would like to work on spatial multi-omics modeling in an interdisciplinary team!

Thanks!