Which YouTube Thumbnail do you prefer?

YouTube video by Dr. Brandon Beaber Neurological Disorders Associated with B12 Deficiency

Neurological Disorders Associated with B12 Deficiency youtube.com/shorts/YHc1n...

Shohei Ohtani is good at baseball

Control of Regulatory T Cell Development by the Transcription Factor Foxp3 Regulatory T cells engage in the maintenance of immunological self-tolerance by actively suppressing self-reactive lymphocytes. Little is known, however, about the molecular mechanism of their develop...

Here is one of the relevant publications: www.science.org/doi/10.1126/...

Nobel Prize in Physiology or Medicine 2025 The Nobel Prize in Physiology or Medicine 2025 was awarded jointly to Mary E. Brunkow, Frederick J. Ramsdell and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance"

Congratulations to 2025 Nobel prize in medicine winners Fred Ramsdell, Mary Brunkow, and Shimon Sakaguchi for discoveries related to immune system tolerance such as Transcription Factor Foxp3, believed to have importance in autoimmune disease www.nobelprize.org/prizes/medic...

YouTube video by Dr. Brandon Beaber Octave Multiple Sclerosis Disease Activity (MSDA) Test Explained by Neurologist

Octave Multiple Sclerosis Disease Activity (MSDA) Test youtu.be/KNSXmlJTUUg?...

Yeah...I suspect that the patient population and even technicalities of the software could be influencing the result. Sometimes resolution of recent edematous lesions can cause pseudoatrophy which is a big factor.

Thanks for the suggestion

Good suggestion but I didn't attend, so I would have to look into this

The effect on brain atrophy of different MS disease modifying therapies based on a network meta-analysis (click the image) pubmed.ncbi.nlm.nih.gov/41080911/

Hypogammaglobulinemia and infections in patients with multiple sclerosis treated with anti-CD20 monoclonal antibodies: a systematic review and meta-analysis of observational studies Monoclonal antibodies targeting CD20 (anti-CD20 mAbs) used in patients with multiple sclerosis (MS) can cause hypogammaglobulinemia and increase the risk of infections. We aim to identify the propo...

What is the risk of serious infections with ocrevus? According to this meta-analysis, about 6% www.tandfonline.com/doi/full/10....

Does anyone have suggestions for YouTube videos I could make about multiple sclerosis?

Understanding Ocrelizumab’s Impact on Advanced Progressive MS: Insights From Dr. Gavin Giovannoni | NeurologyLive - Clinical Neurology News and Neurology Expert Insights Gavin Giovannoni, MBBCh, PhD, FCP, FRCP, FRCPath, lead investigator of the phase 3 ORATORIO-HAND trial, provided comment on the results presented at ECTRIMS 2025, highlighting ocrelizumab’s therapeuti...

The O-HAND trial: Ocrevus showed benefits in primary progressive MS [data presented at ECTRIMS, unpublished]. 30% reduction in a composite disability endpoint compared to placebo. www.neurologylive.com/view/underst....

The frequency and characteristics of multiple sclerosis misdiagnosis referrals to a tertiary center in Saudi Arabia - PubMed MS misdiagnosis is frequent, especially in atypical cases or non-specialist evaluations. Early referral and strict use of McDonald's criteria may reduce diagnostic errors and healthcare costs.

Researchers from Saudi Arabia at a tertiary care center report that 6.6% of those referred for multiple sclerosis were actually misdiagnosed. Most were prescribed unnecessary medication. pubmed.ncbi.nlm.nih.gov/41067083/

People with higher income with multiple sclerosis in New Zeland were more likely to receive highly effective disease modifying therapy. pubmed.ncbi.nlm.nih.gov/41072254/

I mixed it up. The one I created is on the right.

Talk to your own provider as this is controversial

Maternal and neonatal outcomes associated with natalizumab exposure during pregnancy in Iranian patients with multiple sclerosis - PubMed In this cohort, continuing NTZ during pregnancy, including into the third trimester, appeared to be generally well tolerated and not associated with major maternal or neonatal complications. While onl...

Can you take tysabri during pregnancy? Based on a cohort (n=30, Iran): "continuing [including] during pregnancy, including into the third trimester, appeared to be generally well tolerated and not associated with major maternal or neonatal complications." pubmed.ncbi.nlm.nih.gov/41076768/

A thumbnail created by me (left) vs. chat gpt (right). Which do you prefer?

YouTube video by Dr. Brandon Beaber Selma Blair's Multiple Sclerosis Journey

Selma Blair's Multiple Sclerosis Journey youtube.com/shorts/kuZoI...

Nitrofurantoin warning: please read Nitrofurantoin is a commonly prescribed antibiotic for urinary tract infections (UTIs) and is also used long-term as a urinary antiseptic to prevent UTIs.

#MS_Selfie Newsletter - Nitrofurantoin warning: please read

Nitrofurantoin is a commonly prescribed antibiotic for urinary tract infections (UTIs) and is also used long-term as a urinary antiseptic to prevent UTIs. => buff.ly/7gPsotL

Ageing and remyelination failure in people with multiple sclerosis - PubMed One of the most promising strategies to delay, prevent, or reverse disability progression in multiple sclerosis (MS) is enhancing endogenous remyelination. While preclinical research has established a...

If you are too old, is it impossible remyelinate? NO! "There does not appear to be an age cut-off beyond which remyelination is not possible, as there are pathological data supporting remyelination occurring, to some extent, across all ages." pubmed.ncbi.nlm.nih.gov/41048166/

14.3 % of people with MS have paramagnetic rim lesions (PRLs) (dark rim on SWI sequence) which correlate with higher disability [data from Norway] pmc.ncbi.nlm.nih.gov/articles/PMC...

Man who became popular in Blinking White Guy gif raises over $300,000 for multiple sclerosis research Drew Scanlon, a resident of San Francisco, said the case was close to him a friend and his mother are afflicted with it

Drew Scanlon, the man with the famous bewildered blinking meme in 2013 has managed to raise over $300,000 for multiple sclerosis in fundraising bicycle races over the years. One of his friends has the condition. www.theguardian.com/us-news/2025...

YouTube video by Dr. Brandon Beaber Multiple Sclerosis Starts Years Before Symptom Onset

www.youtube.com/watch?v=oxd3...

Dr. Beaber always does a great job translating the data for us medically challenged. Follow him if you already don't: @brandon-beaber.bsky.social

YouTube video by Aaron Boster MD Does Obesity Make Multiple Sclerosis Get Worse Faster?

Does Obesity Make Multiple Sclerosis Get Worse Faster? Very important data shared by @aaronbostermd.bsky.social youtu.be/9UJXK_tKqUg?...

The published MS-STAT2 trial, a phase 3, randomized, double-blind, placebo-controlled trial which DID NOT show any benefit of high dose simvastatin in preventing disability progression in progressive MS. pubmed.ncbi.nlm.nih.gov/41045938/

ECTRIMS 2025: Standard Ocrevus dose holds up in PPMS Topline trial data showed that a higher Ocrevus dose didn't provide more benefit than the standard regimen in people with PPMS.

Higher doses of ocrevus were not more effective than standard doses in the Phase 3b GAVOTTE trial multiplesclerosisnewstoday.com/ectrims/2025...

Head-to-Head Trial Supports New Treatment for Kids With MS A multicenter phase 3 trial comparing ocrelizumab to fingolimod for children with MS achieved its noninferiority primary endpoint while suggesting potential safety advantages.

Ocrevus was superior to gilenya in pediatric MS in a head to head trial (OPERETTA 2 trial) with 48% fewer relapses (annual relapse rate of 0.07 vs 0.14) along with "greater reductions in disease activity on brain imaging." www.medscape.com/viewarticle/...

Various gastrointestinal diseases are more common 5 years prior to MS “symptom onset” (from BC Canada), arguably part of the MS "prodrome" pmc.ncbi.nlm.nih.gov/articles/PMC...