Taka

I usually focus on data analysis, but it had been a while since I last used KNIME, and I built a workflow again. I’m really glad I was able to create the analysis flow successfully.

I’ve been working on building an in vitro evaluation system using human samples, and I finally got results that feel promising for use as a screening system.

Novartis provides update on Phase III GCAptAIN study of Cosentyx® in giant cell arteritis (GCA)

www.novartis.com/news/media-r...

Had two whiskeys. So good.

My first hike of the year!

The advice I received was to maintain my ability to see the big picture, but also develop the skill to dive deep and commit fully when I recognize what’s truly important.
It’s a challenge I’ve been aware of for a while, so hearing it directly was both affirming and encouraging.

However, this can sometimes mean I fall short compared to those who focus deeply and deliver strong results on the one task that really matters.

I recently received some valuable feedback about my work style.
When I have 10 tasks, I tend to push all of them forward, even if task #2 is clearly the most critical.
One of my strengths is having a broad view and managing multiple things at once.

Great job!

Serological ACPA patterns reveal the preferential binding of autoantibodies to citrulline motifs. 6907 RA patients were screened for binding to citrulline containing peptides. The figure visualizes binding to four peptide families with the original peptide with multiple citrulline and the equivalent single citrulline peptides. Patients with any positive signal within the families are shown. A. Cit TNC5 in 3115 positive patients B. Cit Fibβ60-74 in 4474 positive patients C. Cit Fibα36-50 in 2645 positive patients D. Cit Vim60-75 in 4591 positive patients Heatmaps display positive signals in arbitrary units (AU) with the cut-off for positivity in the assays subtracted

ACPA specificity and recognition motifs were examined in 6,907 patients with RA from 5 Scandinavian cohorts. ACPA targeting non-glycine citrulline motifs assoc. more strongly w/ HLA-SE; ACPA to glycine citrulline motifs assoc. w/ smoking and IgA ACPA

A&R
doi.org/10.1002/art....
#Medsky #Immunosky

Even if it’s just internal documents, always include sources for graphs and numbers. Otherwise, it’ll be difficult to review later or hand over to someone else.

The Barking Crab

It was reasonably priced and delicious.

I really enjoyed the conference. I learned a lot

I’m heading to Boston for a conference. I’m really looking forward to it!

Generating ideas is important—it’s the first step of turning nothing into something. But I believe that developing and refining those ideas, taking them from start to finish, is even more valuable.

Let’s not lose sight of our true goals and means. The purpose is to develop medicine, and we shouldn’t let that purpose turn into just a means to navigate corporate politics.

I had a delicious meal and a great conversation with my colleague.

Everyone wants to believe that the path they’ve chosen is the right one. And as long as they put in the effort to make it right for themselves, any path can become the right one

My boss is fully committed to moving my project forward together. It helps me a lot.

NanoBRET® Target Engagement K192 Kinase Selectivity System The NanoBRET® Target Engagement (TE) K192 Kinase Selectivity System can quantitatively measure intracellular compound occupancy against a panel of 192 kinases in a single experiment.

This screening system is based on that technology.

www.promega.jp/products/cel...

Single-plate kinome screening in live-cells to enable highly cost-efficient kinase inhibitor profiling Cancer research, cancer treatment, and the field of chemical biology are examples which heavily rely on the discovery of selective kinase inhibitors. …

Single-plate kinome screening in live-cells to enable highly cost-efficient kinase inhibitor profiling

www.sciencedirect.com/science/arti...

IFN-γ–producing TH1 cells and dysfunctional regulatory T cells contribute to the pathogenesis of Sjögren’s disease Treg cell–specific deletion of Ca2+ influx results in a Sjögren’s disease–like phenotype in mice that is mediated by IFN-γ–producing CD4+ T cells.

IFN-γ–producing TH1 cells and dysfunctional regulatory T cells contribute to the pathogenesis of Sjögren’s disease

www.science.org/doi/10.1126/...

Serum Type I Interferon Score predicts clinically meaningful disease progression in limited cutaneous Systemic Sclerosis Objective To assess the value of serum Type I Interferon (IFN) score in predicting clinically meaningful progression in limited cutaneous systemic sclerosis (lcSSc) using a novel composite endpoint ...

Serum Type I Interferon Score predicts clinically meaningful disease progression in limited cutaneous Systemic Sclerosis
acrjournals.onlinelibrary.wiley.com/doi/10.1002/...

A genome-wide atlas of human cell morphology - Nature Methods An optical pooled cell profiling platform (PERISCOPE) based on Cell Painting and optical sequencing of molecular barcodes was used to develop the first unbiased genome-wide morphology-based perturbati...

A genome-wide atlas of human cell morphology
www.nature.com/articles/s41...

Opportunities and limitations of B cell depletion approaches in SLE - Nature Reviews Rheumatology This Review summarizes lessons learned from the use of rituximab in patients with systemic lupus erythematosus, and discusses the future of B cell targeting therapies, highlighting therapeutic options...

Opportunities and limitations of B cell depletion approaches in SLE
www.nature.com/articles/s41...