Victoria Aranda

154 million lives and counting: 5 charts reveal the power of vaccines - a timely news explainer/reminder by @heidiledford.bsky.social

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🧪 #MedSky

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A human brain map of mitochondrial respiratory capacity and diversity - Nature The ability to physically partition the human brain at a spatial resolution comparable to neuroimaging methods enabled the development of a brain-wide atlas of mitochondrial content, specialization an...

Meet the MitoBrainMap!

The first map of mitochondrial phenotypes provides a foundation for exploring the molecular energetic landscape of a normal brain.
It turns out that the human brain contains diverse mitochondrial phenotypes driven by topology & cell types
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www.nature.com/articles/s41...

#ScientistAtWork photo competition A celebration of the striking and colourful work that scientists do around the world.

Our #Scientistsatwork photo competition is open for submissions.

This is a competition for scientists themselves.

Winners will receive £500, a subscription to Nature & have their photo featured alongside an interview in Nature.

Deadline - March 28th

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www.nature.com/immersive/sc...

How the NIH dominates the world’s health research — in charts (and what we stand to lose)
@nature.com @natureportfolio.nature.com
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www.nature.com/articles/d41...

Clonal dynamics and somatic evolution of haematopoiesis in mouse - Nature Isolating and studying haematopoietic stem cells in young and aged mice demonstrates evolutionary processes related to blood production and provides a framework for interpreting future work using labo...

new out in @nature.com www.nature.com/articles/s41...

Today in Nature, integrating AI in smart watches for loss of pulse detection: www.nature.com/articles/s41... 🧪

Trump 2.0: an assault on science anywhere is an assault on science everywhere US President Donald Trump is taking a wrecking ball to science and to international institutions. The global research community must take a stand against these attacks.

We at Nature denounce this assault on science 🧪 www.nature.com/articles/d41...

Breast cancer is on the rise: data reveal drastic gap in survival rates Lack of screening and limited treatment options mean that low- and middle-income countries face higher death rates despite having fewer cases than wealthier nations.

Breast cancer is on the rise: data reveal drastic gap in survival rates

Lack of screening and limited treatment options mean that low- and middle-income countries face higher death rates despite having fewer cases than wealthier nations

🧪 #MedSky
@nature.com

www.nature.com/articles/d41...

A neoantigen vaccine generates antitumour immunity in renal cell carcinoma - Nature A phase I trial of a neoantigen-targeting personalized cancer vaccine led to durable and polyfunctional T cell responses and antitumour recognition, and was associated with no recurrence in patie...

And renal cancer, too! Cancer vaccines this month in Nature www.nature.com/articles/s41... 🧪

Clonal driver neoantigen loss under EGFR TKI and immune selection pressures - Nature We show the evolution of a case of EGFR mutant lung cancer treated with a combination of erlotinib, osimertinib, radiotherapy and a personalized neopeptide vaccine targeting somatic mutations, includi...

And more clinical exploration of cancer vaccines this week in Nature: www.nature.com/articles/s41... 🧪

RNA neoantigen vaccines prime long-lived CD8+ T cells in pancreatic cancer - Nature In a phase 1 trial, patients with pancreatic ductal adenocarcinoma who were treated with surgery and bespoke neoantigen mRNA vaccines combined with anti-PD-L1 and chemotherapy exhibited marked lo...

This week in Nature, important (in more than one sense ) results about mRNA vaccines long term effects in pancreatic cancer: www.nature.com/articles/s41... 🧪

Trump administration to cut billions in medical research funding National Institutes of Health said the $4bn loss will affect ‘indirect’ funding of buildings, equipment and staff

Simply inexplicable!
Trump administration to cut billions in medical research funding
🧪 #AcademicSky

www.theguardian.com/us-news/2025...

Children’s arithmetic skills do not transfer between applied and academic mathematics - Nature Children who learn maths working in markets and children who learn maths only from school were both unable to transfer their skills to new contexts, highlighting a need to reconsider how maths is...

Do you ever wonder whether teaching children math in a classroom translates to applied skills? or if those kids that can do applied math would perform well in a classroom setting? A new @nature.com paper shows that these skills do not translate 🧪 www.nature.com/articles/s41...

How one language family took over the world: ancient DNA traces its spread Millennia-old genomes suggest Indo–European tongues originated from the Caucasus mountain region.

Nearly half the world’s population speaks at least one of the roughly 400 Indo–European languages. Now ancient genomes tell us how it came to pass
@nature.com 🧪
www.nature.com/articles/d41...

Out of Africa: celebrating 100 years of human-origins research A landmark study reporting the discovery of Australopithecus africanus one century ago put the African continent at the centre of the story of humanity.

www.nature.com/articles/d41... 🧪

Expanding the human gut microbiome atlas of Africa - Nature A cross-sectional study from four African countries shows the importance of investigating the gut microbiome in previously under-represented populations and provides a framework for equitable microbio...

Out now in @nature.com: Gut microbiome diversity across African populations - a valuable resource for further research and foundational for global health equity. 🧪

www.nature.com/articles/s41...

CARD domains mediate anti-phage defence in bacterial gasdermin systems - Nature Caspase recruitment domains (CARDs) are present in defence systems that protect bacteria against phage, where the bacterial CARD domain is essential for protease-mediated activation of bacte...

Out now in @nature.com: Elegant work demonstrating CARD-dependent activation of bacterial gasdermins. 🧪

www.nature.com/articles/s41...

Global meta-analysis shows action is needed to halt genetic diversity loss - Nature A comprehensive meta-analysis of global terrestrial and marine genetic diversity covering more than three decades of research demonstrates rapid loss of genetic diversity and identifies conservation i...

How can we stop genetic diversity loss? A meta-analysis in @nature.com finds the conservation strategies designed to improve environmental conditions, increase growth rates, and introduce new individuals can maintain or increase genetic diversity🧪https://www.nature.com/articles/s41586-024-08458-x

Engineered heart muscle allografts for heart repair in primates and humans - Nature Epicardial engineered heart muscle allografts from induced pluripotent stem cell-derived cardiomyocytes can safely and effectively remuscularize chronically failing hearts in rhesus macaques, leading ...

This week in Nature, translational and clinical cardiac stem cell engineering: “Engineered heart muscle allografts for heart repair in primates and humans” www.nature.com/articles/s41... 🧪

Fine-tuning gibberellin improves rice alkali–thermal tolerance and yield - Nature Precise regulation of the phytohormone gibberellin to optimal levels may not only confer alkali–thermal tolerance to Green Revolution rice varieties but may also further enhance their yield, and ...

Crops face a variety of challenging conditions, including alkaline soil and global warming. @nature, scientists gain molecular insights and apply them to not only make rice both alkali- and temperature-tolerant, but also to further increase its yield. www.nature.com/articles/s41...

Ancient human genomes offer clues about the earliest migrations out of Africa Oldest Homo sapiens genomes point to dates of mixture with Neanderthals.

Analyses of 45,000-year-old bones from Europe allow scientists to pin down when modern humans interbred with Neanderthals, shedding light on the histories of populations with no present-day descendants

https://go.nature.com/4h7FCbA

30th Anniversary Series on the Future of Medicine As Nature Medicine celebrates the 30th anniversary of it’s launch, we reflect on what the future holds for medicine and for our journal.

To celebrate its 30th anniversary, Nature Medicine launches a new series to spotlight key challenges & opportunities over the next 30 years of biomedical innovation 🎉
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@natureportfolio.bsky.social

www.nature.com/collections/...

Immune evasion through mitochondrial transfer in the tumour microenvironment - Nature Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired antitumour immunity.

A study in Nature confirms that the phenomenon of mitochondrial transfer can occur bidirectionally between cytotoxic T cells and cancer cells within the tumour microenvironment. This leads to senescence of the T cells and impaired antitumour immunity.
www.nature.com/articles/s41... 🧪

This is figure 3, which shows the crystal structures of 3FTx-binding proteins closely matched those of the design models.

A study in Nature used deep learning methods to design proteins that can neutralize the effects of three-finger toxins found in snake venom, which could lead to the development of safer and more accessible antivenom treatments. https://go.nature.com/4aDxmxK 🧪

Bluesky’s science takeover: 70% of Nature poll respondents use platform Roughly 6,000 readers answered our poll, with many declaring that Bluesky was nicer, kinder and less antagonistic to science than X.

Roughly 6,000 readers answered our poll, with many declaring that Bluesky was nicer, kinder and less antagonistic to science than X

https://go.nature.com/42tH8Ai

Rapid and scalable personalized ASO screening in patient-derived organoids - Nature A scalable platform for generating patient-specific organoids for testing personalized oligonucleotide therapeutics is described.

This week in Nature, how a platform of cardiac organoids can accelerate ASO therapeutic development in DMD: “Rapid and scalable personalized ASO screening in patient-derived organoids” 🧪 www.nature.com/articles/s41...

Precise modelling of mitochondrial diseases using optimized mitoBEs - Nature A study reports optimized mitochondrial base editors with reduced off-target effects to facilitate the generation of mouse models of human mitochondrial diseases.

More disease modeling technology this week in Nature, through optimization of mitochondrial base editing: “Precise modelling of mitochondrial diseases using optimized mitoBEs” 🧪 www.nature.com/articles/s41...

The road to CAR-T-cell therapy for lethal childhood brain tumours A phase I trial in young people with a form of glioma tests immune cells engineered to target cancer cells.

Promising results from a phase I clinical trial of GD2-CAR T cells (immune cells engineered to target the molecule GD2) in children & young adults with diffuse midline gliomas — incurable cancers of the CNS
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A clinical briefing on a new @nature.com paper

www.nature.com/articles/d41...

Joint speech and text machine translation for up to 100 languages - Nature SEAMLESSM4T is a single machine translation tool that supports speech-to-speech translation, speech-to-text translation, text-to-speech translation, text-to-text translation and automatic speech recog...

Remember Bable Fish from The Hitchhiker’s Guide to the Galaxy? A single model that supports speech-to-speech translation, speech-to-text translation, text-to-speech translation, text-to-text translation & automatic speech recognition is here!

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www.nature.com/articles/s41...

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