David Hettle

Great to join #ReActAfrica and @southcentre.bsky.social at #AARC25 for 2 days of discussion and learning about #AMR across Africa

#antimicrobialresistance

#neosky #neoEBM #neonates #neonatalsepsis #sepsis #africa @plosglobalpublichealth.org @espr-esn.bsky.social @vanessacarteramr.bsky.social

Look after patients with neonatal sepsis in sub-Saharan Africa?

🫵We want to hear from YOU!

❓Why❓
Exploring clinicians experiences of diagnostics, antibiotics + guidelines

📢 English, French or Portuguese

🔗 redcap.sun.ac.za/surveys/?s=N9A…

📢 Healthcare workers across Africa — we want to hear from you! Together, we can improve newborn health in LMICs. 💪👶Don't forget to take our survey before 10 May 2025!📝
🔗 redcap.sun.ac.za/surveys/?s=N...

Sepsis is one of the most frequent causes of death worldwide & yet in many LMICs we have no or low quality phenotypic diagnostics to guide our therapy. This is particularly problematic in the context of neonatal sepsis where ESBL Kleb pneumo is often implicated. @lshtmamrcentre.bsky.social

Back at the #ESCMIDGlobal clinical round - watching the experts' #clinicalreasoning in all kinds of cases

🧫 First up - Whipple's disease

Long-term arthralgia
Cardiac involvement
Persistent diarrhea even after fevers settle

#ESCMID2025 #IDSky

Amazing to present our work (with @tinamwat.bsky.social) on developing blood culture processes in Harare 🇿🇼 at #ESCMID2025 #ESCMIDGlobal

And great to meet others + chat about the work's impact in #neonatalsepsis + #AMR #AMS #antimicrobialstewardship

@thruzim.bsky.social

But it is a lovely circle...

I guess I found it helpful to visualise the process of how these COULD work in a best-case and so can aspire to?

Essential diagnostics in low-resource settings

Sipho Dlamini, Dissou Affolabi, @makedasemret.bsky.social insights on
💥 Brain drain
💥 Lack of granularity in calls to improve
💡 Lessons of networks (echoing TB labs) in SSA

Current status: www.thelancet.com/journals/lan...

#ESCMIDGlobal #ESCMID2025

#AI is here + will become key in #antimicrobialstewardship #AMS

Flagged by Prof Thursky @ncas.bsky.social at #ESCMID2025 #ESCMIDGlobal - this paper is a great blueprint for implementing AI in AMS programmes

Link: www.thelancet.com/journals/lan...

New Frontiers in Antimicrobial Stewardship @escmid.bsky.social

Keynote lecture: Karin Thursky @ncas.bsky.social

How can we reframe + conceptualize #AMS to work for 2025 + beyond.

Who outside of healthcare really know the ins and outs of what #AMR #AMS mean?

#ESCMIDGlobal #ESCMID2025

Critical talk to think about moving from #AMR surveillance + antibiotic use data
⬇️
Stewardship initiatives #AMS

Talk from Mark de Boer on bridging the gap!

#ESCMIDglobal #ESCMID2025

Could there be ways to collect appropriateness data at the time of prescription?

The retrospective review of the notes is the super time-consuming part! And trying to understand 'between-the-lines' clinical reasoning.

Agreed. Hard/expensive to prove, especially in LMICs where difficult to even access all the antibiotics that are used

Just in the session on Proxy Indicators now

Starting Sunday at #ESCMID2025 #ESCMIDglobal debating 'Proxy indicators: bridging the gap between #AMR surveillance and #antimicrobialstewardship #AMS

Finding a way to tie quantity metrics to appropriateness of prescription

A start to #AMS Sunday according to @dianeashiru.bsky.social

Are you at #ESCMID2025 #ESCMIDglobal?

Do you care for patients with neonatal sepsis, and work in sub-Saharan Africa?

Please complete this survey looking at care of neonates + fighting #AMR in sub-Saharan Africa

#neonates #neonatalsepsis #sepsis

Great to hear from @idiots-pod.bsky.social @erinmccreary.bsky.social @jakescottmd.bsky.social at #ESCMID2025 #ESCMIDglobal on social media and podcasts in #IDsky #infectiousdiseases

Rapid bacterial identification and resistance detection using a low complexity molecular diagnostic platform in Zimbabwe Background Sepsis is a major cause of mortality in low-resource settings. Effective microbiological culture services are a bottleneck in diagnosis and surveillance. Aim We aimed to evaluate the perf...

Molecular cartridge based diagnostics have been a game changer for TB diagnostics - why can we not do the same for blood cultures?
Please see our newest publication in collaboration with FIND, Sally Mugabe Central Hospital, the NMRL & @thruzim.bsky.social

PLOS: dx.plos.org/10.1371/jour...

Do you care for patients with neonatal sepsis in sub-Saharan Africa?

🫵We want to hear from YOU!

redcap.sun.ac.za/surveys/?s=N9A…

❓Why❓
To explore clinicians views on diagnostics, antibiotics and guidelines

📢In English, French or Portuguese.

#neonatalsepsis #neonates #sepsis