Bryan D. James, PhD

Honored to be the first @amjepi.bsky.social Editor Spotlight! If you ever have any questions about the journal or the peer review process, or using social media for research, please feel free to hit me up!

Got to finally meet Xian Wu in person instead of zoom! Have enjoyed working with her on these two projects that she presented as posters today at #AAIC2025

@bucklr01.bsky.social killing it on the big stage, unveiling the X chromosome’s role in Alzheimer’s disease! #AAIC2025

Actually, Dr Freeze more apropos

@rushalzheimers.bsky.social colleagues showed up to support!

Also comparing across countries can lead to ecological fallacy (ie differences across groups don’t prove that intervening on these behaviors in individuals will lead to better health in those individual)

A lot to say about this: while I agree with your recommendations, we need to base them on scientific evidence. And here the outcome is cognitive function, not life expectancy (may not necessarily have same determinants)—not much evidence that prevalence of dementia is lower in Europe than US

Love my Alzheimer’s research peeps!

Check out @lamhine.bsky.social’s poster 749 showing multiracial Americans are the racial group with the SECOND highest prevalence of subjective cognitive decline 🤯 Much more research needed in this understudied population (that Tracy and I happen to be a part of) #AAIC2025

If White Lotus aired on the Food Network

Hearing from trial participants and how much the lifestyle changes have changed their lives is incredible: “a new lease on life” We always need to hear from the participants!

“I did lose something. I lost the title of prediabetic. And 11 inches off my waistline.” 👏👏

It could be argued these results are not huge but it is comparing a structured intervention to a self-guided intervention (not an inactive control group) and both groups improved. Were ethical reasons not to, but if trial had compared to inactive controls, effect would likely be massive!

US POINTER study showed a significant improvement in global cognition for a structured intervention (physical, social, and cognitive activities, MIND diet, health monitoring) compared to self-guided intervention equivalent to 1-2 years of aging #AAIC2025. Evidence that behavior change can work

U.S. POINTER Lifestyle Intervention Improved Cognition | AAIC U.S. POINTER is the first large-scale clinical trial to show that healthy lifestyle behaviors targeting multiple risk factors can protect cognitive function.

BREAKING from #AAIC25: U.S. POINTER, a large-scale, randomized controlled clinical trial, shows a healthy lifestyle program targeting multiple risk factors can protect cognitive function in diverse populations in communities across the United States. bit.ly/USPointerRel...

Takeaways from U.S. POINTER top line results:
➡️ Both a structured & a self-guided intervention improved cognition, with the structured group improving even more.
➡️ Cognitive benefits were consistent across age, sex, ethnicity, heart health status and APOE e4 genotype.
bit.ly/USPointerRel... #AAIC25

Yi was not able to make it to AAIC (thanks Visa restrictions 🙄) so I’ll be standing by the poster at 10:30 and 3:30

Come check out #AAIC2025 Poster 807! Work from my R01 with Melinda Power, led by Yi Chen on the association of different neuropathologies with a timely diagnosis of dementia in healthcare settings. Medicare claims linked to @rushalzheimers.bsky.social cohort data

For *prompting me to share. Dumb autocorrect

For #AAIC2025 attendees: #ADRD researcher starter pack! Thanks @tyk314.net for promoting me to share this again

go.bsky.app/22DpUEy

Sure thing!

Really appreciate the #AAIC2025 plenary starting with @alzassociation.bsky.social CEO Joanne Pike saying about the US government’s dramatic cutting of research funds: “We share your outrage”.

Excited to be in Toronto for #AAIC2025! Tough days for scientific research lately but we soldier on to make advancements in preventing and treating Alzheimer’s disease and related dementias #endalz

In light of today’s news about the National Cancer Institute announcing a 4% payline, it’s really important to communicate to people that the previous 10% payline was still effectively a lottery and the result of decades of underfunding the NIH. Paylines used to be 25%.

This cannot be overstated. The scientists at NWS did their jobs. The officials running government operations in Texas did not.

www.wired.com/story/meteor...

My daughter was at Camp Waldemar just a few miles from Mystic and thankfully up on a hill. All the girls are safe but camp is evacuated and over. So incredibly close to the unfathomable tragedy Mystic is experiencing. The larger political background to this makes me so incredibly angry

Thank you to all who checked in—Cora was at another camp on a hill above the Guadalupe that was spared the horrible flood. All the girls are safe. But the camp has damage and no power and had to evacuate. My girl is safe with family and we are going down to TX soon ♥️ My heart breaks for Camp Mystic

As wave of dementia cases looms, Law School looks to preserve elders’ rights— Harvard Gazette Academic experts seek improvements that could protect decision-making authority and autonomy.

Thanks to The Harvard Gazette for featuring our work on cognition and financial decision making in older age presented at the recent The Petrie-Flom Center for Health Law Policy, Biotechnology, and Bioethics at Harvard Law School conference.

news.harvard.edu/gazette/stor...

@societyforepi.bsky.social members: A call for involvement! Please sign up to serve on an SER committee: epiresearch.org/call-for-inv... Ends June 30!

Being on the Awards Committee has made me feel so connected to SER's mission and community. We need YOU, now more than ever! #episky #SER2025

Did you know that living in a disadvantaged neighborhood may increase the risk of developing dementia?

Read more at www.rush.edu/news/where-y...

#AlzheimersandBrainAwarenessMonth

Lack of virtue signaling