Oihane Uriarte Huarte

Figure 1 showing the strategy to isolate nuclei from the brain including blood vessels and the epigenetic profiles of 6 major brain cell types.

Happy to share our latest work led by @kevincziegler.bsky.social and Aydan Askarova, examining cell type contributions of vascular cell types to dementia risk. Many thanks to the donors, and for support from @ukdri.ac.uk and @alzassociation.bsky.social.
www.cell.com/neuron/fullt...

Questions about becoming an #ALZFunded researcher? Stop by Booth 1010 in the #AAIC25 Exhibition Hall today through Wednesday, 10:30 a.m.- 4:15 p.m., for more information on how we support dementia scientists throughout the field.

🏆 Bart de Strooper, M.D., Ph.D., is the recipient of the Khalid Iqbal Lifetime Achievement Award. #AAIC25

@ucl.ac.uk‬ @cbdresearch.bsky.social @ukdri.ac.uk

Welcome to all of those joining us in-person in Toronto for #AAIC25!

We're looking forward to a week of networking, collaboration and learning both virtually and in "The 6ix." 🍁🦫

How does APOE change your risk of developing Alzheimer's disease? At least partially by changing the function of immune cells in your brain 🧠🧬

New paper out in @natcomms.nature.com today: www.nature.com/articles/s41...

@ukdri.ac.uk @kingsioppn.bsky.social @imperialbrains.bsky.social

Unlock the power of past Alzheimer's clinical trials! 🧠

Drs. Mark Dubbelman and Sietske Sikkes join the ISTAART Voices podcast to explore how better access to trial data can improve patient stratification for disease-modifying therapies in Alzheimer’s research and care!

🎧alz.org/ISTAARTpodcast

Dear immune/glia lovers of brain, gut and beyond… We’re looking for a lab tech/manager to join our team! Pls see details for application here ucl.ac.uk/work-at-ucl/se… @ukdri.ac.uk @uclqsion.bsky.social - pls help circulate among networks who’d be of interest, thank you!

A man stands at a podium speaking. Text reads "Registration is now open! Alzheimer's Association AAIC25, Toronto, Canada and Online, July 27-31"

Collaborate with top researchers from around the 🌍 and help propel the next wave of progress in dementia science at #AAIC25, July 27 - 31 in Toronto, Canada, and online. Early-bird registration closes May 16. Register now to save: alz.org/aaic.

Delighted to welcome our new class of ISTAART Ambassadors for 2025! This year's 43 Ambassadors represent 27 countries across the globe. They'll work with us at #AAIC25 Toronto & online & we'll be mentoring them over the next year!

Meet them at alz.org/ISTAARTambassadors

@alzassociation.bsky.social

Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease Hematopoietic stem cell transplant is the gold standard for treatment of globoid cell leukodystrophy, also called Krabbe disease. Aisenberg et al. define the molecular signature of disease-associated macrophages (globoid cells) and demonstrate that brain-specific high-efficiency macrophage replacement in the twitcher model of Krabbe disease improves neuropathology, macrophage dysfunction, and survival.

Online now: Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease

A first first-author paper by Aydan Askarova with @mangiruben.bsky.social & @sj-marzi.bsky.social showing that genetic risk for neurodegenerative conditions is linked to disease-specific microglial pathways. @ukdri.ac.uk 🎉 🍾
journals.plos.org/plosgenetics... More to come from Aydan soon!

Interleukin-34-dependent perivascular macrophages promote vascular function in the brain The niche signals critical for the homeostasis and functions of the brain border-associated macrophages (BAMs) are not well understood. Van Hove et al. demonstrate that BAMs require IL-34 derived from mural cells and perivascular fibroblasts for their maintenance in adulthood. They show that BAMs are required to promote normal vascular function in the brain.

Online now: Interleukin-34-dependent perivascular macrophages promote vascular function in the brain

Monocytes can efficiently replace all brain macrophages and fetal liver monocytes can generate bona fide SALL1+ microglia Replacing brain macrophages holds substantial therapeutic promise but remains challenging. Bastos et al. uncover the requirements for monocytes to replace microglia and border-associated macrophages. They show that monocyte ontogeny shapes brain macrophage identity, with fetal monocytes acquiring a true microglial state. Using xenotransplantation and Alzheimer’s patient data, they identify human monocyte-derived microglia. These findings are important for microglia replacement therapies.

Online now: Monocytes can efficiently replace all brain macrophages and fetal liver monocytes can generate bona fide SALL1+ microglia

CHAS infers cell type-specific signatures in bulk brain histone acetylation studies of neurological and psychiatric disorders Murphy et al. develop CHAS, a computational tool that uncovers cell type-specific patterns in bulk tissue histone acetylation data. Applying CHAS to brain disorders reveals distinct cell type targets ...

We are so happy to share our latest paper "CHAS infers cell type-specific signatures in bulk brain acetylation studies of neurological and psychiatric disorders".

www.cell.com/cell-reports...

@ukdri.ac.uk @kingsioppn.bsky.social @imperialbrains.bsky.social

Excited to share this new work led by the talented Mike Dolan @dolan in collaboration with Evan macosko
See below for details and preprint

VCID-UMD Grant | Alzheimer's Association Alzheimer’s Disease Strategic Fund: Vascular Contributions to Cognitive Impairment and Dementia - Understanding Mechanisms of Dysfunction (VCID-UMD) – learn about grant objectives, eligibility and dea...

‼️🚨⚠️ New @alz.org grant announcement!

ADSF: Vascular Contributions to Cognitive Impairment and Dementia - Understanding Mechanisms of Dysfunction (VCID-UMD) is now OPEN!

LOI deadline: May 30, 2025 5 pm ET/USA @istaart.bsky.social

alz.org/research/for_researchers/grants/types-of-grants/vcid-umd

Harnessing human iPSC-microglia for CNS-wide delivery of disease-modifying proteins Widespread delivery of therapeutic proteins to the brain remains challenging. To determine whether human induced pluripotent stem cell (iPSC)-microgli…

Congratulations to
Dr. Jean Paul Chadarevian and the entire @blurtonjoneslab.bsky.social team for this beautiful piece of work: Harnessing human iPSC-microglia for CNS-wide delivery of disease modifying proteins." 👍👍👍
www.sciencedirect.com/science/arti...

Parkinson's researchers discover 'tip of the ICE-berg' on quest for a cure Parkinson's researcher Malú Tansey brings cell-level science to IU’s already strong clinical research program. Her lab engages in "paradigm-shifting work" studying inflammation and immune...

Nice highlight on the incredible work of @malutansey.bsky.social and team! #goteamstark

medicine.iu.edu/blogs/resear...

Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease - Nature The immune-checkpoint molecule TIM-3 regulates microglial homeostasis, and its microglial-specific deletion reduced cognitive impairment in a mouse model of Alzheimer’s disease.

With Butovsky Lab, we show that silencing TIM-3 in brain-resident immune cells prevents neurodegeneration in a mouse model of #Alzheimer’s disease. Deletion of TIM-3 in microglia enhance phagocytic clearance of toxic amyloid beta. #Immunosky🧪 www.nature.com/articles/s41...

📢Tune in to ISTAART Voices!

Drs. Gregory Jicha and Peter Nelson compare emerging anti-amyloid therapies to biologics used in cancer and other diseases. This conversation highlights novel therapies transforming Alzheimer's treatment!

Listen now at alz.org/ISTAARTpodca...! 🎧

A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer’s disease - Nature Medicine The ratio between the levels of two synaptic proteins in cerebrospinal fluid predicts future cognitive resilience versus decline among presymptomatic individuals and individuals with early Alzheimer’s...

A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer’s disease @naturemedicine.bsky.social
www.nature.com/articles/s41...

Excited to share our findings on how APOE genotype impacts cell responses to AD using human brain snRNAseq. Huge thanks to the team for all the hard work! @drneurochic.bsky.social @mayoclinic.org @cp-neuron.bsky.social

AAIC APOE and lipid biology conference participants watching a manatee in Miami

The highlight of #AAIC APOE and lipid biology? @liddelowsa.bsky.social and @oihaneuh.bsky.social seem to think so! 🥰🦭

Glycocalyx dysregulation impairs blood–brain barrier in ageing and disease - Nature Disruption of mucin-domain glycoprotein expression and function in the endothelial glycocalyx are associated with ageing and Alzheimer’s disease, leading to dysregulated blood–brain barrier function.

Glycocalyx dysregulation impairs blood–brain barrier in ageing and disease

www.nature.com/articles/s41...

A high-throughput assay platform to discover small molecule activators of the phospholipase PLC-γ2 to treat Alzheimer’s disease A naturally occurring missense variant of the phospholipase C isozyme, PLC-γ2, harboring a single substitution (P522R) protects against several neurodegenerative diseases, including Alzheimer’s diseas...

Excited to be part of the work-"A high-throughput assay platform to discover small molecule activators of the phospholipase PLCG2 to treat Alzheimer’s disease"- now out in JBC !
Huge thanks to Qisheng and the team for this amazing collaborators! www.jbc.org/article/S002...

a cartoon character is pointing at a map of the world . ALT: a cartoon character is pointing at a map of the world .

Excited to be in #Pittsburgh for the @alzassociation.bsky.social #AAICNeuroNext conference.
This hybrid global conference is free and run in parallel in Barcelona, Belgrade, Buenos Aires, Ibadan, Indianapolis, Nairobi, New Delhi, Pittsburgh, Porto Alegre, Santiago, Thessaloniki, and Yaoundé!

Dive into the complex relationship between Alzheimer's and Lewy body pathologies with Dr. Duygu Tosun on the latest episode of ISTAART Voices! Discover how cutting-edge research is paving the way for innovative treatments.

New episode, out now at alz.org/ISTAARTpodcasts

@alzassociation.bsky.social

YouTube video by Paige Logan The ISTAART Ambassador Program: Your Passport to a Global Dementia Research Community

The ISTAART Ambassador Program is still open for applications!

Hear what the current cohort has to say about the program, what it meant to them, and why you should apply!

www.youtube.com/watch?v=Y_7-...

CUT&Tag recovers up to half of ENCODE ChIP-seq histone acetylation peaks Techniques for genome-wide epigenetic profiling have been undergoing accelerated development toward recovery of high-quality data from bulk and single cell samples. DNA-protein interactions have tradi...

📢 CUT&Tag version 3

Sometimes the preprint to paper route can be quite the odyssey. And so in that vein, we are delighted to give you version 3 of our CUT&Tag optimization and benchmarking manuscript:

www.biorxiv.org/content/10.1...

AAIC Award Nominations are open.

Submit a nomination today for the AAIC Lifetime Achievement Awards, the Bill Thies Award for Distinguished Service to ISTAART and the Inge Grundke-Iqbal Award for Alzheimer's Research.

aaic.alz.org/about/awards...