β-Amyloid induces microglial expression of GPC4 and APOE leading to increased neuronal tau pathology and toxicity - Molecular Neurodegeneration To define how Aβ pathology alters microglia function in Alzheimer’s disease, we profiled the microglia surfaceome following treatment with Aβ fibrils. Our findings reveal that Aβ-associated human micr...

Excited to share a new paper I contributed to in Molecular Neurodegeneration!

Aβ drives microglial GPC4 & APOE, promoting tau pathology via an amyloid-glia-tau axis. Grateful to the team, esp. @bbholmes.bsky.social

https://molecul…/articles/10.1186/s13024-025-00883-4

#Alzheimers #Research #Neuro