Vittorio Rispoli

Invasive neurophysiology and whole brain connectomics for neural decoding in patients with brain implants - Nature Biomedical Engineering A modularized open-source pipeline for invasive brain signal decoding bridges the gap between closed-loop neuromodulation and clinical brain–computer interface approaches in a large patient cohort.

New paper in Nature Biomedical Engineering by @timonmerk.bsky.social !

We built a platform that unites AI-based brain signal decoding with connectomics across 123 hours of recordings from 73 patients. A step toward adaptive, network-level neurotechnology.

www.nature.com/articles/s41...

🚨 New preprint out! 🚨
“Translating the Transcriptome: A Connectomics Approach for Gene-Network Mapping and Clinical Application”
🔗 doi.org/10.1101/2025... 

🧵 A short thread:

Kudos to Davide Fontanesi, Giulia Saccardin, Edoardo Monfrini, Barbara Garavaglia, Alessio Di Fonzo, and the entire team behind this work.

#dystonia #neurogenetics #VPS16 #MDSGene #movementdisorders #movedisorder

In this paper, we describe a newly identified case of VPS16-related hyperkinetic disorder and offer a detailed literature review on phenotype based on the MDS Gene methodology, with particular attention to onset, progression and peculiar clinical features.

We're excited to share our latest work:
“A Twisting Diagnosis: A New Case of VPS16-Related Hyperkinetic Spectrum and Literature Review” — now published in @Movement Disorders Clinical Practice #MDCP_Journal

Find out more here:
onlinelibrary.wiley.com/share/author...

Can we reboot walking after Parkinson's disease DBS?
Can AI teach deep brain stimulation devices to help people 'walk the walk?' A new study by Wang says MAYBE. Using personalized data-driven models, they optimized DBS for walking.
@parkinsondotorg.bsky.social #parkinson @ucsfhealth.bsky.social

🧠 ⚡️ Preprint alert ⚡️ 🧠

I️n the most comprehensive review of DBS in epilepsy, with 124 studies, 1,210 patients, and 20 anatomical targets we map where stimulation works best and why.

Deep Brain Stimulation for Epilepsy: Optimal Targeting and Clinical Outcomes
www.researchgate.net/publication/...

Frequency- and layer-specific effects of high-frequency STN stimulation on mouse motor cortical areas in vivo Abstract. High-frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective evidence-based therapy for Parkinson’s disease; howe

Take a look at our new work, providing explanations for the mechanisms of deep brain stimulation, with insights into the modulation of motor- premotor cortex activity from mouse-based and translatable research methodologies for future therapy solutions
shorturl.at/5Atjh

Classifying neurogenic dysphagia as a movement disorder Swallowing is a complex sensorimotor task with widespread control throughout the nervous system. Jones et al. explore swallowing disorders in neurological

academic.oup.com/brain/advanc.... This is interesting

Tremor is a common symptom across many neurological disorders.

But is there a shared tremor circuit across disorders - one that could guide treatment, regardless of diagnosis?

We think: yes.

Our study is out now in @natcomms.nature.com:

🔗 www.nature.com/articles/s41...

🧵 A thread.

The apomorphine era has arrived…but do you know how we got here? After nearly two centuries of false starts, misuses, and rediscoveries, apomorphine is finally center stage in Parkinson’s disease therapy with the FDA approval of a subcutaneous infusion pump in 2025. Do you know the history?

Is there a role for noninvasive "network" stimulation (multifocal tDCS) to evaluate candidates for deep brain stimulation?

@lukasgoede.bsky.social says yes – new study here:

onlinelibrary.wiley.com/doi/10.1002/...

A 🧵

@netstim.org @braincircuits.bsky.social @lead-dbs.org

Patient Selection in Deep Brain Stimulation: A Role for Transcranial Direct Current Stimulation to Enhance the Levodopa Challenge? Dopaminergic medication and deep brain stimulation (DBS) improve motor symptoms in Parkinson's disease (PD), but levodopa response alone may not predict DBS outcomes. We retrospectively analyzed 19 P...

Patient selection for Deep Brain Stimulation (DBS) is crucial.
Are there ways to improve it?

In our new study, we found hints that non-invasive brain stimulation might enhance the levodopa response
- and serve as an additional marker for DBS outcomes.

doi.org/10.1002/acn3...

A thread. 🧵

Extended coverage of human serum glycosphingolipidome by 4D-RP-LC TIMS-PASEF unravels association with Parkinson’s disease - Nature Communications 4D-TIMS-glycosphingolipidomics expedite clinical serum profiling of 376 GSLs covering ganglio- and neolacto-series, neutrals and sulfatides. Clinical phenotyping of Parkinson’s disease cohort (sub)gro...

#Glycosphingolipidomics alterations iincluding #peripheral #immunity dependant profiles in #Parkinsons disease New Manuscript allert in #NatComm go.nature.com/43AalJZ

#Neurology
#Medicine

MR guided focused ultrasound surgery is an effective and uprising treatment option for Essential tremor. But where is the optimal site to sonicate? Which spots to avoid due to side-effects?

@science.org @braincircuits.bsky.social @netstim.org

– a thread🧵!

www.science.org/doi/10.1126/...

New paper in Imaging Neuroscience by Jack A. Reeves, Ferdinand Schweser, et al:

IRONMAP: Iron network mapping and analysis protocol for detecting over-time brain iron abnormalities in neurological disease

doi.org/10.1162/imag...

Are we getting closer to noninvasive temporal interference stimulation instead of DBS? Maybe? DBS has been amazing; as we seek citius, altius, fortius; the swifter, higher and stronger approaches, we realize that the mountain is quite steep. TIS modulated beta oscillations deep in the human brain.

🚨 🥁 Preprint alert:
The Deep Brain Stimulation Response Network in Parkinson’s Disease Operates in the High Beta Band
->> www.researchgate.net/publication/... <<--

Wouldn't it be cool to be able to stimulate deep w/in the brain w/o the need for brain surgery, and without actually making a physical lesion in the brain (i.e. FUS or pallidotomy)? This paper provides 'proof of concept' that a transcranial ultrasound stimulation (TUS) approach may be achievable.

Schematic summary of therapeutic effects of dopamine and deep brain stimulation (DBS) across spatial, spectral, and temporal scales in Parkinson's disease.

Excited to have my PhD project paper exploring the network mechanisms of neuromodulation accepted for publication!

We show how deep brain stimulation and medication exert a shared modulation of motor network synchrony in Parkinson's disease.

Very excited by this paper led by Savir Madan & @laurenahart.bsky.social, which introduces the first self-train dataset for learning Lead-DBS and a nice tool to self-assess how well localizations compare to expert solutions.

ICYMI: New online! Parkinson disease pathology can originate in the kidney https://bit.ly/41sGYrY

Out now in Brain Stimulation

Towards accredited training in brain stimulation: proceedings from the Brain Stimulation Subspecialty Summits (BraSSS)

with co-host Nolan Williams and 23 other awesome co-authors including some from @braincircuits.bsky.social

www.brainstimjrnl.com/article/S193...

@europepmc.org does have all* of PubMed indexed (and indeed partners with PMC for full text) - in addition to other sources (incl. for preprints).

OpenAlex (openalex.org) and Lens (lens.org) similarly include all* PubMed records, as does @openaire.bsky.social (but less easy to filter in webUI)

1/

A "key transcriptomic hallmark" in Parkinson's: Lower SNCA expression in genetic (SNCA, GBA, LRRK2) and non-genetic cohorts. This finding, "previously obscured by immune cell signatures," further supports the loss of function hypothesis. @biorxivpreprint.bsky.social
www.biorxiv.org/content/10.1...

All that jerks is not myoclonus, not all who needle find benefit.

Our editorial on the new IAPRD myoclonus classification is online.

@albertoespay.bsky.social

www.prd-journal.com/article/S135...

Illustration showing a diverse group of four people standing in a line, with a person at the right looking back at them with an arm extended. The image features a caption that reads, "WORKING LIFE — One mentor isn’t enough. Here's how I build a network of mentors."

"One email at a time, one informational interview after another, I became comfortable, confident, and strategic in building my network of mentors."

One mentor isn’t enough, wrote Erika Moore in this 2021 #ScienceWorkingLife essay. https://scim.ag/3DWR4YV #NationalMentoringMonth

Interested in modeling DBS induced white matter activations?
Konstantin Butenko has a new preprint on all the options available within OSS-DBS / @lead-dbs.org including Electric Field Projections and probabilistic Pathway Activation Modeling:

www.medrxiv.org/content/10.1...

New paper in Imaging Neuroscience by Gavin Hsu, Lucas C. Parra, et al:

Dose–response of tDCS effects on motor learning and cortical excitability: A preregistered study

direct.mit.edu/imag/article...