Matthias Fellner

Dual mechanisms of digestion-resistant proteins in food systems: structural resistance and enzyme inhibition Digestion-resistant proteins, which are proteins that reduce or inhibit the digestive process of dietary nutrients, might be an emerging field to explore. Growing public interest in food compositio...

Check out our latest review on digestion-resistant proteins, a collaboration with the Zhang lab (China Agricultural University) and Otago @otagobiochemist.bsky.social / Food Sciences. doi.org/10.1080/1040...

07.09.2025 21:53 — 👍 0    🔁 1    💬 0    📌 0

Identification of covalent inhibitors of Staphylococcus aureus serine hydrolases important for virulence and biofilm formation - Nature Communications Staphylococcus aureus is a leading cause of bacteria-associated mortality worldwide. New tools are needed to both image and treat this pathogen. We previously identified a group of S. aureus serine hy...

Our work identifying new covalent inhibitors of Staphylococcus aureus serine hydrolyses from fragment libraries is out! great work from @tulsiupadhyay.bsky.social and our many collaborators, including @christianslentz.bsky.social, @mfellnerlab.bsky.social. #chembio
link.springer.com/article/10.1...

30.05.2025 21:55 — 👍 42    🔁 11    💬 2    📌 1

Great collaboration with Suzanne Warring, Hazel Sisson @peterfineran.bsky.social and others to combat kiwifruit canker via an endolysin-lipase chimera, grateful to be involved, check it out here: www.jbc.org/article/S002...

13.05.2025 07:38 — 👍 4    🔁 2    💬 1    📌 0

An mRNA Display Approach for Covalent Targeting of a Staphylococcus aureus Virulence Factor Staphylococcus aureus (S. aureus) is an opportunistic human pathogen that causes over one million deaths around the world each year. We recently identified a family of serine hydrolases termed fluorop...

Well done @sijiewang.bsky.social and everyone else involved
pubs.acs.org/doi/10.1021/...

01.03.2025 11:32 — 👍 1    🔁 0    💬 0    📌 0

Identification of Covalent Cyclic Peptide Inhibitors Targeting Protein–Protein Interactions Using Phage Display Peptide macrocycles are promising therapeutics for a variety of disease indications due to their overall metabolic stability and potential to make highly selective binding interactions with targets. R...

Amazing work by @sijiewang.bsky.social and our collaborators is out in JACS today. Interested in covalent inhibitors of protein-protein interactions? Check it out. pubs.acs.org/doi/10.1021/...

25.02.2025 02:51 — 👍 30    🔁 11    💬 1    📌 0

Activity-Based Protein Profiling Identifies an α-Amylase Family Protein Contributing to the Virulence of Methicillin-Resistant Staphylococcus aureus In search of new putative antimicrobial drug targets in methicillin-resistant Staphylococcus aureus, we aimed to identify and characterize retaining glycosidase activities in this bacterial pathogen. ...

New article out in ACS Infectious Diseases! Using activity-based probes by H. Overkleeft, former PhD candidate @jalal228.bsky.social identified an alpha-amylase family protein of S. aureus supporting virulence during Galleria infection! @monaj66.bsky.social pubs.acs.org/doi/10.1021/...

11.02.2025 08:38 — 👍 16    🔁 6    💬 0    📌 2

FphH and FphI cryo and room temperature crystal structures.

Happy to share our paper "Similar but Distinct—Biochemical Characterization of the Staphylococcus aureus Serine Hydrolases FphH and FphI" in PROTEINS doi.org/10.1002/prot... - cryo vs room temperature protein crystallography, SAXS, molecular dynamics and much more to uncover key enzyme differences.

29.12.2024 23:09 — 👍 2    🔁 0    💬 0    📌 0

Just out Comparative lipidomics profiles of planktonic and biofilms of methicillin-resistant and -susceptible Staphylococcus aureus: doi.org/10.1016/j.ab... MS & NMR to dig into lipid differences between strains, living states & media. Get in contact to investigate your lipids of interest together!

13.12.2024 10:43 — 👍 3    🔁 1    💬 0    📌 0