Iris

Agentic AI and the rise of in silico team science in biomedical research - Nature Biotechnology This study examines the emerging use of agentic artificial intelligence (AI) in biomedical research, highlighting the challenges and opportunities that may inform the design of agentic AI systems suit...

A new @natbiotech.nature.com Perspective outlines the key algorithms and foundational building blocks driving agentic AI, and discusses biomedical applications, design considerations, and the challenges ahead in making agentic AI deployable at scale in biomedicine. www.nature.com/articles/s41...

Agentic AI and the rise of in silico team science in biomedical research - Nature Biotechnology This study examines the emerging use of agentic artificial intelligence (AI) in biomedical research, highlighting the challenges and opportunities that may inform the design of agentic AI systems suit...

Our perspectives piece on Agentic AI for biomedical research has been published in Nature Biotechnology www.nature.com/articles/s41... #agenticAI #artificialintelligence #agents

Clinical progress of engineered cellular immunotherapies for autoimmunity - Nature Biotechnology Engineered cellular immunotherapy shows great potential for treating autoimmune diseases. Payne and colleagues review emerging clinical data of the most recently developed technologies.

Engineered cellular immunotherapies for autoimmunity are advancing fast, with many now in clinical trials. This @natbiotech.nature.com Review breaks down what emerging data reveal — and where the field is heading next. www.nature.com/articles/s41...

Developmentally inspired synthetic kidney engineering - Nature Biotechnology Hughes and colleagues present a developmentally inspired tissue engineering strategy to overcome barriers in kidney tissue generation, enhancing prospects for renal replacement therapies.

A new Review in @natbiotech.nature.com presents a vision for engineering synthetic kidneys inspired by natural development. A promising step toward future renal replacement therapies. www.nature.com/articles/s41...

A new review from the Doudna Lab lab on tissue-targeted in vivo delivery of gene editors: https://www.nature.com/articles/s41587-025-02945-w

#CRISPR #delivery

Integrated experimental and AI innovations for RNA structure determination - Nature Biotechnology RNA’s dynamic nature and complex physiochemical properties make it difficult to structurally resolve. This Perspectives examines how integrating experimental and computational approaches to structure ...

RNA structures are hard to solve, but experimental and computational approaches are evolving. This new Perspective in @natbiotech.nature.com shows how their interplay will be the driving force to help the field forward. www.nature.com/articles/s41...

How do you detect transgenes in genome-edited crops? We tested several methods and report our findings in 2 back-to-back papers: onlinelibrary.wiley.com/doi/10.1111/...
rdcu.be/eLgUi

The COP16 decision established a multilateral mechanism for digital sequence information benefit-sharing. DSI researchers assess what has been accomplished so far and identify remaining challenges go.nature.com/4nBE4t8
rdcu.be/eJnid

Redefining druggable targets with artificial intelligence - @wcmenglanderipm.bsky.social @aihealthmit.bsky.social go.nature.com/4fHNMYi

Engineering B cells to treat and study human disease - Nature Biotechnology Recent developments in B cell engineering expand our ability to study human disease and drive progress toward new B cell therapies, balancing challenges in clinical implementation with emerging opport...

How can we engineer B cells to treat diseases? Read about the latest developments of this exciting field in this new Review out now in @natbiotech.nature.com www.nature.com/articles/s41...

Can senolytics reverse or slow aging?
Table of companies pursuing this goal.
So far the results are questionable.
@natbiotech.nature.com
www.nature.com/articles/s41...

Unlocking gene regulatory networks for crop resilience and sustainable agriculture - Nature Biotechnology Gene regulatory networks are crucial for understanding complex gene regulation in plants and could advance crop improvement for more sustainable and climate-resilient agricultural practices.

Gene regulatory networks are crucial for understanding complex gene regulation in plants and could help improve crops for more sustainable and climate-resilient agriculture. Read about it in this Review out now in @natbiotech.nature.com www.nature.com/articles/s41...

Improving engineered biological systems with electronics and microfluidics - Nature Biotechnology A classification of hybrid engineered biological systems is presented to support researchers in making design choices that expand their use.

This Review presents a classification system of hybrid engineered biological systems to support researchers in making design choices, out now in @natbiotech.nature.com www.nature.com/articles/s41...

Base editors model mitochondrial disease - Nature Biotechnology Optimized TALE base editors are used to generate a rat model of mitochondrial disease and then revert the disease mutation in the next generation.

Base editors model mitochondrial disease #NBTNV - @mikrobenjaeger.bsky.social go.nature.com/45O9PJM

Anatomy of the 23andMe fall and implications for consumer genomics - Nature Biotechnology 23andMe’s bankruptcy serves as a moment of reflection for the direct-to-consumer (DTC) genomics industry. We analyzed 23andMe financial data and business practices to reveal the factors behind the fal...

Anatomy of the 23andMe fall and implications for consumer genomics go.nature.com/3Hf6sBE

Enabling next-generation anaerobic cultivation through biotechnology to advance functional microbiome research - Nature Biotechnology Overcoming key hurdles for the development of next-generation anaerobic cultivation methods could have major impacts on microbial community research and applications.

Overcoming key hurdles for the development of next-generation anaerobic cultivation methods could have major impacts on microbial community research and applications. Read how in this new Perspective in @natbiotech.nature.com www.nature.com/articles/s41...

A call for built-in biosecurity safeguards for generative AI tools - Nature Biotechnology Nature Biotechnology - A call for built-in biosecurity safeguards for generative AI tools

A call for built-in biosecurity safeguards for generative AI tools go.nature.com/3GIpTlR

Enabling next-generation anaerobic cultivation through biotechnology to advance functional microbiome research Nature Biotechnology - Overcoming key hurdles for the development of next-generation anaerobic cultivation methods could have major impacts on microbial community research and applications.

Here we share thoughts on next-gen cultivation: rdcu.be/ejPSb. Hope it helps 😄 Was fun to write with great colleagues @lisamaierlab.bsky.social @jselkrig.bsky.social @baerboletta.bsky.social @typaslab.bsky.social @mmmicrobiomelab.bsky.social @leibniz-dsmz.bsky.social @westermannlab.bsky.social

1/ We need new ways of producing foods and fuels to minimise our impact on our planet. Our new paper now in
@natbiotech.nature.com examines whether microbes hold the key to producing foods and fuels in the future
Open access: rdcu.be/eiIUu
nature.com/articles/s41...

Cancer vaccines: the experts speak - Nature Biotechnology The development of therapeutic cancer vaccines has long been a promising yet challenging field of research. While early efforts were impeded by limited efficacy and immune escape, recent advances in i...

The development of therapeutic cancer vaccines is seeing exciting progress recently. Curious how researchers are dealing with challenges to translate new technologies to the clinic? @natbiotech.nature.com asked experts for an update. www.nature.com/articles/s41...

Making cell therapy accessible: challenges and opportunities - Nature Biotechnology Despite major advances in bringing cancer cell therapies to the clinic, their widespread accessibility remains a substantial challenge. High manufacturing costs, lack of funding and varying regulatory...

Cell therapies are transforming our ability to treat cancer but are out of reach for many patients. @natbiotech.nature.com asked experts to share their insights into pressing challenges and promising strategies to make these therapies more broadly accessible www.nature.com/articles/s41...

A look back at what vaccines have done.

Proud of our new perspective describing the role of mathematical biology for immunotherapy www.nature.com/articles/s41... @natbiotech.nature.com

This month, we've focused on recent developments as well as challenges in cancer immunotherapy, including cancer vaccines, immune checkpoint inhibitors, and CAR-engineered cells. Please read more👇

Engineering innate immune cells for cancer immunotherapy - Nature Biotechnology The unique attributes of innate immune cells position them as attractive candidates for cancer immunotherapy, with engineering strategies to enhance their antitumor potential, offering notable therape...

Innate immune cells are promising candidates for cancer immunotherapy and various engineering strategies can be employed to set them up for success. Read about is in this Review in @natbiotech.nature.com and don't forget to check out our full Focus Issue! www.nature.com/articles/s41...

🔥New Night Science paper!!
Discovery happens when your initial plans fall apart but it requires you to have a particular mindset: it's not extraverted, orderly, neurotic or agreeable that's the most important – discovery requires an OPENNESS to new ideas and unexpected insights.

Pharma stocks sink after ouster of top FDA vaccine regulator Shares of U.S. drugmakers fell on Monday after reports that the Food and Drug Administration's top vaccine official, Peter Marks, had been forced to resign, the most high-profile exit at the regulator as the Trump administration undertakes an overhaul of federal health agencies.

Shares of US drugmakers fell after reports that @fda.gov top vaccine official, Peter Marks, had been forced to resign, as the Trump administration undertakes an overhaul of federal health agencies #NBTNewsBeat www.reuters.com/business/hea...

The emerging landscape of engineered bacteria cancer therapies - Nature Biotechnology Our ability to use engineered bacteria for cancer therapy is rapidly expanding. A survey of preclinical, clinical and commercial efforts provides an overview of the state of the field, revealing trend...

Check out the state of the field of engineered bacteria for cancer therapy in this Comment in @naturebiotech.bsky.social www.nature.com/articles/s41...

Induced proximity at the cell surface - Nature Biotechnology Technologies to modulate induced proximity at the cell surface advance the manipulation of diverse biological responses.

Modulating induced proximity at the cell surface is a powerful engineering strategy that can find diverse applications in basic and translational science. Curious to learn about emerging modalities in this space? Read this review out now in @naturebiotech.bsky.social www.nature.com/articles/s41...

Toward single-molecule protein sequencing using nanopores Nature Biotechnology - Maglia and colleagues discuss advances in nanopore technology en route to single-molecule protein sequencing

Nanopore technology might be able to sequence proteins soon! Read about the road ahead in this exciting Perspective rdcu.be/edWPi in @naturebiotech.bsky.social