Caleb Browne

And that’s a wrap folks for #CAN2025. Thanks to everyone who came and participated in the science and conversations and we conclude with the past (me), now present ( @rcbagot.bsky.social ) and future ( @markcembrowski.bsky.social ) chairs of the @canacn.bsky.social meeting. See you in Montreal 2026!

Thanks, Derya!

We hope these data will be a useful resource for the field, and that our findings could help guide the development of therapeutic strategies shaped by the unique impacts of different forms of substance use disorder.

Throughout the paper, outline general patterns of transcriptional regulation, gene networks and biological processes and affected, and try to identify some underlying regulatory systems involved.

Using RNAseq on FACS-sorted nuclei from D1 or D2 MSNs across different exposure conditions, we find that while these different classes of drugs induce a lot of parallel changes to the transcriptome, many patterns of gene expression are highly divergent, particularly in D2s.

Cocaine and morphine induce shared and divergent transcriptional regulation in nucleus accumbens D1 and D2 medium spiny neurons - Molecular Psychiatry Molecular Psychiatry - Cocaine and morphine induce shared and divergent transcriptional regulation in nucleus accumbens D1 and D2 medium spiny neurons

Happy to share our new paper in Molecular Psychiatry, co-led by Philipp Mews with @ericjnestler.bsky.social, where we compare how cocaine and morphine cause cell-type-specific transcriptional restructuring in the nucleus accumbens to inform processes occurring in SUD. www.nature.com/articles/s41...

🇨🇦🇨🇦🇨🇦💪💪💪

A crucial role for the cortical amygdala in shaping social encounters - Nature The posterolateral cortical amygdala and other connected brain regions have a key role in mediating the transition from investigative to aggressive behaviour in male mice.

1/4 I am very pleased to share this new manuscript, “A crucial role for the cortical amygdala in
shaping social encounters”, led by 2 spectacular postdocs, Dr. Tony Aubry who is on the job market, and coauthor @neuromanonyc.bsky.social

Read it here: www.nature.com/articles/s41...

Hi bluesky, The Martinez-Rivera Lab's website is now available! Pls share! :)
www.martinezriveralab.org

Re-upping this: Deadline is Feb 15th. PI position at our Research Institute at The Hospital for Sick Children in Toronto. Successful candidate will be cross-appointed at U of T. Great research community, great city! Early- and mid-career applications welcome.

can-acn.org/scientist-se...

Come join us @umontreal.ca - We're looking to recruit a Professor in the field of neurobiology, with a focus on linking neurodevelopment to neural circuit function and dysfunction.
#neuroskyence #neuroscience 🧪

See ad below -
www.fens.org/careers/job-...

Omar Abubaker, Eric Nestler and I spoke about how science brings hope for those suffering from alcohol and substance use disorders at an Advocacy forum @sfn.org #SfN24. Our message is that as scientists we need to be better at communicating this. @ericjnestler.bsky.social