Florent Delhommel

Molecular mechanisms of biomolecular condensate formation in Drosophila melanogaster siRNA biogenesis Abstract. Biogenesis of small interfering RNAs (siRNA) in Drosophila melanogaster involves the processing of double-stranded RNA (dsRNA) by Dcr-2 with Loqs

New paper in collaboration with the Förstemann Lab & Boekhoven Lab is out! Combining #NMR & mutational analysis, we characterize the unique features of the #Ago2 IDR region which drives Ago2/RNA #condensate formation.
doi.org/10.1093/nar/...
@clarahipp.bsky.social

J'entends Aurore Bergé sur @franceinfo.fr expliquer que les gens sont contres la loi Duplomb parce qu'ils sont désinformés.
Désinformés par qui ? 14 sociétés savantes ? La ligue contre le cancer ? Le CNRS écologie environnement ?

Very happy to share our preprint on heavy metal associated (HMA) domain-containing rice proteins bound by the rice blast MAX effector AVR-Pia! 🌾

You designed binders for your favourite protein and wish there was a way to experimentally screen them within 24h w/ only a set of pipettes and a plate reader?

Check out our Cell-Free 2-Hybrid approach (CF2H)

Full post: tinyurl.com/48cz5nb6

Preprint: www.biorxiv.org/cgi/content/...

One of our group members @clarahipp.bsky.social had the great opportunity to attend the Nobel Laureate Meeting last week in sunny Lindau ☀️
#lino25

Quantifying the carbon footprint of conference travel: the case of NMR meetings Abstract. Conference travel contributes to the climate footprint of academic research. Here, we provide a quantitative estimate of the carbon emissions associated with conference attendance by analyzi...

Read our preprint related to an important topic: climate change 👉 mr.copernicus.org/preprints/mr...
As scientists, we rely on data for rational decisions. Climate science is clear: human-made CO₂ emissions are changing our climate fast. But what can we do about it—individually or as a community? 1/n

Unique conformational dynamics and protein recognition of A-to-I hyper-edited dsRNA Abstract. Adenosine-to-inosine (A-to-I) editing is a highly abundant modification of double-stranded RNA (dsRNA) and plays an important role in posttranscr

📢 Paper with @sattler-lab.bsky.social now published in @narjournal.bsky.social ! doi.org/10.1093/nar/... We combine #NMR, #SAXS, and #MD to construct conformational ensembles, showing that A-to-I hyper-editing leads to significant structural dynamics. MD simulations by @piompons.bsky.social

We are happy to announce the “10th European solid-state NMR summer school” (October 19-24, 2025) that will take place at the Technical University Munich (@TUM.de) in Garching, Germany. #NMRchat #BioNMR

For more detailed information, please follow the link:
www.bio.nat.tum.de/ocb/upcoming...

Rachel Thomas, PhD - Deep learning gets the glory, deep fact checking gets ignored an AI researcher going back to school for immunology

"a fascinating case study on the limits of AI in biology and the harms of current publishing incentives" rachel.fast.ai/posts/2025-0...

Thrilled to share our new method in-cyclo NMR that lets us watch molecular machines in action — decoding molecular machine kinetics with atomic precision and exceptional time resolution in one go! 🚀 Check it out: doi.org/10.1038/s414... #NMR #StructuralBiology

Structural and Functional Characterization of the 28 kDa Structured Core of BmSA1, the Major Surface Antigen of Babesia Microti Babesiosis is a tick-borne disease that poses a significant threat to animal health worldwide. In addition, climate change and the risk of human-to-human transmission through blood transfusion have m...

A new paper from the CBS !
Structural and Functional Characterization of the 28 kDa Structured Core of BmSA1, the Major Surface Antigen of Babesia Microti
onlinelibrary.wiley.com/doi/10.1002/...

Triple Labeling Resolves a GPCR Intermediate State by Using Three-Color Single Molecule FRET The correlation of individual conformational changes in dynamic protein complexes remains challenging as most structural methods rely on averaged information over a large number of molecules. Single molecule FRET is a powerful tool for monitoring such conformational changes. When performed using three distinct probes, it enables the correlation of domain movements by providing up to three simultaneous distance measurements with high temporal resolution. Nevertheless, a major challenge lies in the site-specific attachment of three probes to unique positions within the target protein. Here, we propose an orthogonal triple-labeling strategy that is not compromised by native, reactive amino acid functionalities. It combines genetic code expansion and bioorthogonal labeling of two different noncanonical amino acids with an enzymatic self-labeling SNAP tag. We demonstrate its application by establishment of a 3-color sensor on the human metabotropic glutamate receptor 2, a dimeric, multidomain G protein-coupled neuroreceptor, and describe a previously unknown conformational intermediate state using 3-color single molecule FRET.

Our new study is out !
We introduce a triple labeling strategy (2 non canonical Amino Acids + 2 click chemistries and 1 SNAP-tag) to triple label a G-protein coupled receptor.
Open access in JACS
pubs.acs.org/doi/10.1021/...

L'UE va investir 500 millions d'euros pour attirer les chercheurs Paris - L'Union européenne va proposer une "nouvelle enveloppe de 500 millions d'euros" pour la période 2025-2027 "afin de faire de l'Europe un pôle d'attraction pour les chercheurs", a annoncé lundi ...

“Choose Europe for Science” : L’UE va investir 1/7ème de ce que la France vient de supprimer au budget de la recherche. 2+2=5 www.lexpress.fr/informations...

Once again, a great collaboration between the Buchner Lab, the @sattler-lab.bsky.social and the Rosenzweig Lab!

Schematic of Hsp90's conformational cycle and the effect of Sgt1 that stabilizes the client's complex and prevents Aha1 binding.

New preprint is out! We've looked at the interactions of Sgt1 with Hsp90 in yeast and found some surprising results! We've also shown that in the presence of clients, Sgt1 prevents aha1 binding on Hsp90 and thus increases the substrate's dwell time. #NMR #chaperone

www.biorxiv.org/content/10.1...

QDS target Hla to disarm S. aureus
New work IDs quinoxalinediones as small molecules that protect host cells by neutralizing S. aureus toxin α-hemolysin & preventing pore formation, highlighting how a large toxin can be inhibited by a small molecule
www.cell.com/cell-host-mi...

Cryo-EM structure and regulation of human NAD kinase The cryo-EM structures of human NADK in its free form and bound to NAD+ uncover key insights into its regulatory mechanisms.

New paper from our lab !

Cryo-EM structure and regulation of human NAD kinase | Science Advances www.science.org/doi/10.1126/...

Etats-Unis : un chercheur français refoulé pour avoir exprimé « une opinion personnelle sur la politique menée par l’administration Trump » Le ministre de la recherche a dit sa « préoccupation », mercredi, après cette décision des autorités américaines. Le chercheur du CNRS aurait subi un contrôle aléatoire à son arrivée, avant que son or...

French researcher, going to a conference in Houston, was forbidden entry to US; his work and personal electronics were both confiscated.

Why? Because a “random search” of his cell phone revealed a negative personal opinion on Trump and the Trump administration. www.lemonde.fr/internationa...

I think it's important to reach out to your own community and explain what the funding cuts mean in practice.

📢Aujourd'hui l'Institut Pasteur se mobilise pour la science, l'inclusion & l'avenir du savoir avec l'organisation du symposium «Excellence Scientifique : et si l'inclusion était la clé ?» en écho avec la Journée Internationale des Droits des Femme & la participation au mouvement #StandUpForScience !

#standupforscience
Campus Arnaud de Villeneuve, Montpellier, France
@standupforscience.bsky.social
@standupforscifr.bsky.social

#StandUpforScience au @cbsmontpellier.bsky.social
#StandForScience_Montpellier.

« Défendons les sciences face aux nouveaux obscurantismes » TRIBUNE. En écho au mouvement américain de protestation contre la politique de Donald Trump, un collectif de personnalités françaises appelle citoyens et scientifiques à rejoindre le mouvement « Stand...

« Défendons les sciences face aux nouveaux obscurantismes »

En écho au mouvement américain « Stand up for Science » contre la politique de Trump, un collectif de personnalités françaises appelle citoyens et scientifiques à une journée de mobilisation le 7 mars.

👇
www.lemonde.fr/sciences/art...

NIH cuts billions of dollars in biomedical funding, effective immediately The move halts a large slice of money for most universities and research institutions virtually overnight, imperiling vital research in everything from cancer to heart disease.

NIH has cut billions of dollars in biomedical funding, effective immediately
The move halts a large slice of money for most universities and research institutions virtually overnight, imperiling vital research in everything from cancer to heart disease.

www.washingtonpost.com/health/2025/...

Communiqué du Conseil Scientifique du CNRS recommandant aux institutions et laboratoires de recherche affiliés à évaluer la pertinence de leur présence sur une plate-forme aussi toxique que X.

En raison des dérives de X, dont l'algo semble rendre complètement inopérant le partage d'informations scientifiques & la confrontation sereine des idées, le Conseil Scientifique du @cnrs.bsky.social invite les instituts & laboratoires affiliés à évaluer la pertinence de leur présence sur X.

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The known unknowns of the Hsp90 chaperone An exploration of the unanswered questions in how the molecular chaperone Hsp90 supports protein homeostasis, and how single-molecule techniques could drive future breakthroughs in answering them.

What a way to start 2025! Our review on the Known Unknowns of the Hsp90 Chaperone has been published!
Huge thanks to Laura Silbermann and Benjamin Vermeer for all of their efforts, and to @scisonja.bsky.social for the great collaboration :)
You can read it here:
elifesciences.org/articles/102...

ATTENTION pour une raison inconnue notre compte bluesky avait été supprimé ! Nous l'avons recréé mais nous avons perdu tous nos abonnés. Merci de diffuser l'information

The BEST-HMBC-HMQC experiment for pairing geminal methyl groups in Valine and Leucine side-chains. Methyl groups are essential probes for characterising interactions and dynamics in large proteins. HN-based triple-resonance NMR experiments are often too insensitive for methyl assignments, making a ...

Preprint, The BEST-HMBC-HMQC expt for pairing geminal methyl groups in Valine and Leucine side-chains. Ana P.A. Alva, Lucas Siemons, Ulric le Paige, Coline Wiame, Florence Cordier, Nicolas Wolff, Guillaume Bouvignies, Philippe Pelupessy, Fabien Ferrage chemrxiv.org/engage/chemr... #NMRchat #NMR 🧲

Structural basis of orientated asymmetry in a mGlu heterodimer - Nature Communications Metabotropic glutamate receptors exist as both homo- and heterodimers. Here, the authors report the mGlu2-4 receptor structures in the inactive, intermediate and active states, and reveal the reason f...

Our new study is out ! We combined #cryoEM and #smFRET to reveal the structural basis of the activation of an heterodimeric #GPCR, the metabotropic glutamate receptor mGluR2-4.
Fantastic collaboration with the teams of Jean-Philippe Pin, Yan Zhang & Jianfeng Liu.
www.nature.com/articles/s41...

Molecular architecture of thylakoid membranes within intact spinach chloroplasts Thylakoid membranes coordinate the light reactions of photosynthesis across multiple scales, coupling the architecture of an elaborate membrane network to the spatial organization of individual protei...

This one was delayed for a while… apologies to the musicians. Collab with Matt, Will and Lorna (over on Twitter). And a great dev effort from Lorenz @lorenzlamm.bsky.social. Ofc @cellarchlab.com team. Comment if you want to help. #teamthylakoid

www.biorxiv.org/content/10.1...