Florent Delhommel

Congrats to our lab member Philipp, who defended his PhD this week! 🎓🎉

Watch Robert Quast @rbquast.bsky.social from our Team presenting our work on single molecule #FRET on #GPCR in the first FBI Connect webainar !

We are hiring a 2-year postdoctoral researcher to join our Membrane Biophysics team at the CBS in Montpellier. Join us to reinvent Atomic Force Microscopy to image the most common interface on our planet: the surface of water @membranesbiophy.bsky.social @cbsmontpellier.bsky.social

graphical abstract showing the combination of techniques used to analyze the dynamics of a de novo enzyme.

Our latest work is out! We combined #NMR with #Crystallography, #MD, and #ProteinMPNN to analyze the conformational dynamics of a de novo enzyme and redesigned it! Great collaboration between
@cathleenzeymer.bsky.social and the @sattler-lab.bsky.social.

www.cell.com/structure/fu...

Don’t miss this opportunity to work with a fantastic mentor, a great team, in a beautiful city of France!

Highly endowed ERC Synergy Grant for Prof. Johannes Buchner Disease-causing proteins – ERC Synergy Grant for research at TUM on the role of chaperone “helper proteins.”

Misfolded proteins can cause #Alzheimers, #Parkinsons and #Cancer. Johannes Buchner, part of the CHAPEROME team, receives an #ERC Synergy Grant to study how chaperone #proteins keep cells healthy: go.tum.de/904052 👏

#ERCSyG #biotechnology
@erc.europa.eu

📷A. Heddergott

We are hiring a PhD student!!
The project starts as early as January 2026 and is fully funded for three years.
Everyone with interest in NMR-centered structural biochemistry of nucleic acid-protein interactions in virus-infected cells, get in contact!
biochemie.uni-greifswald.de/forschung/fo...

Lancement ce jour du projet d'extension de notre laboratoire. 1100m² de nouveaux espaces et 280m² rehabilités.
Merci pour leur soutien à nos tutelles et nos partenaires.
@inserm.fr @cnrs.fr @umontpellier.bsky.social
@occitanie.bsky.social @villedemontpellier.bsky.social
& l'Etat

Thrilled to share my first corresponding author paper as a project leader in @hillerlab.bsky.social ‪ Amazing work from first author @annaleder.bsky.social We discovered multi-chaperone condensates in the ER that revolutionise the current vision of protein folding!
www.nature.com/articles/s41...

BNMRZ Symposium Ultra-Highfield NMR and 4D Structural Biology – From Mechanisms to Therapies, November 6–7, 2025, TUM Institute for Advanced Study, Garching @ias-tum.bsky.social registration opens soon www.bnmrz.org/4dstructbiol #BNMRZ #NMRchat #NMR 🧲

Molecular mechanisms of biomolecular condensate formation in Drosophila melanogaster siRNA biogenesis Abstract. Biogenesis of small interfering RNAs (siRNA) in Drosophila melanogaster involves the processing of double-stranded RNA (dsRNA) by Dcr-2 with Loqs

New paper in collaboration with the Förstemann Lab & Boekhoven Lab is out! Combining #NMR & mutational analysis, we characterize the unique features of the #Ago2 IDR region which drives Ago2/RNA #condensate formation.
doi.org/10.1093/nar/...
@clarahipp.bsky.social

J'entends Aurore Bergé sur @franceinfo.fr expliquer que les gens sont contres la loi Duplomb parce qu'ils sont désinformés.
Désinformés par qui ? 14 sociétés savantes ? La ligue contre le cancer ? Le CNRS écologie environnement ?

Very happy to share our preprint on heavy metal associated (HMA) domain-containing rice proteins bound by the rice blast MAX effector AVR-Pia! 🌾

You designed binders for your favourite protein and wish there was a way to experimentally screen them within 24h w/ only a set of pipettes and a plate reader?

Check out our Cell-Free 2-Hybrid approach (CF2H)

Full post: tinyurl.com/48cz5nb6

Preprint: www.biorxiv.org/cgi/content/...

One of our group members @clarahipp.bsky.social had the great opportunity to attend the Nobel Laureate Meeting last week in sunny Lindau ☀️
#lino25

Quantifying the carbon footprint of conference travel: the case of NMR meetings Abstract. Conference travel contributes to the climate footprint of academic research. Here, we provide a quantitative estimate of the carbon emissions associated with conference attendance by analyzi...

Read our preprint related to an important topic: climate change 👉 mr.copernicus.org/preprints/mr...
As scientists, we rely on data for rational decisions. Climate science is clear: human-made CO₂ emissions are changing our climate fast. But what can we do about it—individually or as a community? 1/n

Unique conformational dynamics and protein recognition of A-to-I hyper-edited dsRNA Abstract. Adenosine-to-inosine (A-to-I) editing is a highly abundant modification of double-stranded RNA (dsRNA) and plays an important role in posttranscr

📢 Paper with @sattler-lab.bsky.social now published in @narjournal.bsky.social ! doi.org/10.1093/nar/... We combine #NMR, #SAXS, and #MD to construct conformational ensembles, showing that A-to-I hyper-editing leads to significant structural dynamics. MD simulations by @piompons.bsky.social

We are happy to announce the “10th European solid-state NMR summer school” (October 19-24, 2025) that will take place at the Technical University Munich (@TUM.de) in Garching, Germany. #NMRchat #BioNMR

For more detailed information, please follow the link:
www.bio.nat.tum.de/ocb/upcoming...

Rachel Thomas, PhD - Deep learning gets the glory, deep fact checking gets ignored an AI researcher going back to school for immunology

"a fascinating case study on the limits of AI in biology and the harms of current publishing incentives" rachel.fast.ai/posts/2025-0...

Thrilled to share our new method in-cyclo NMR that lets us watch molecular machines in action — decoding molecular machine kinetics with atomic precision and exceptional time resolution in one go! 🚀 Check it out: doi.org/10.1038/s414... #NMR #StructuralBiology

Structural and Functional Characterization of the 28 kDa Structured Core of BmSA1, the Major Surface Antigen of Babesia Microti Babesiosis is a tick-borne disease that poses a significant threat to animal health worldwide. In addition, climate change and the risk of human-to-human transmission through blood transfusion have m...

A new paper from the CBS !
Structural and Functional Characterization of the 28 kDa Structured Core of BmSA1, the Major Surface Antigen of Babesia Microti
onlinelibrary.wiley.com/doi/10.1002/...

Triple Labeling Resolves a GPCR Intermediate State by Using Three-Color Single Molecule FRET The correlation of individual conformational changes in dynamic protein complexes remains challenging as most structural methods rely on averaged information over a large number of molecules. Single molecule FRET is a powerful tool for monitoring such conformational changes. When performed using three distinct probes, it enables the correlation of domain movements by providing up to three simultaneous distance measurements with high temporal resolution. Nevertheless, a major challenge lies in the site-specific attachment of three probes to unique positions within the target protein. Here, we propose an orthogonal triple-labeling strategy that is not compromised by native, reactive amino acid functionalities. It combines genetic code expansion and bioorthogonal labeling of two different noncanonical amino acids with an enzymatic self-labeling SNAP tag. We demonstrate its application by establishment of a 3-color sensor on the human metabotropic glutamate receptor 2, a dimeric, multidomain G protein-coupled neuroreceptor, and describe a previously unknown conformational intermediate state using 3-color single molecule FRET.

Our new study is out !
We introduce a triple labeling strategy (2 non canonical Amino Acids + 2 click chemistries and 1 SNAP-tag) to triple label a G-protein coupled receptor.
Open access in JACS
pubs.acs.org/doi/10.1021/...

L'UE va investir 500 millions d'euros pour attirer les chercheurs Paris - L'Union européenne va proposer une "nouvelle enveloppe de 500 millions d'euros" pour la période 2025-2027 "afin de faire de l'Europe un pôle d'attraction pour les chercheurs", a annoncé lundi ...

“Choose Europe for Science” : L’UE va investir 1/7ème de ce que la France vient de supprimer au budget de la recherche. 2+2=5 www.lexpress.fr/informations...

Once again, a great collaboration between the Buchner Lab, the @sattler-lab.bsky.social and the Rosenzweig Lab!

Schematic of Hsp90's conformational cycle and the effect of Sgt1 that stabilizes the client's complex and prevents Aha1 binding.

New preprint is out! We've looked at the interactions of Sgt1 with Hsp90 in yeast and found some surprising results! We've also shown that in the presence of clients, Sgt1 prevents aha1 binding on Hsp90 and thus increases the substrate's dwell time. #NMR #chaperone

www.biorxiv.org/content/10.1...

QDS target Hla to disarm S. aureus
New work IDs quinoxalinediones as small molecules that protect host cells by neutralizing S. aureus toxin α-hemolysin & preventing pore formation, highlighting how a large toxin can be inhibited by a small molecule
www.cell.com/cell-host-mi...

Cryo-EM structure and regulation of human NAD kinase The cryo-EM structures of human NADK in its free form and bound to NAD+ uncover key insights into its regulatory mechanisms.

New paper from our lab !

Cryo-EM structure and regulation of human NAD kinase | Science Advances www.science.org/doi/10.1126/...

Etats-Unis : un chercheur français refoulé pour avoir exprimé « une opinion personnelle sur la politique menée par l’administration Trump » Le ministre de la recherche a dit sa « préoccupation », mercredi, après cette décision des autorités américaines. Le chercheur du CNRS aurait subi un contrôle aléatoire à son arrivée, avant que son or...

French researcher, going to a conference in Houston, was forbidden entry to US; his work and personal electronics were both confiscated.

Why? Because a “random search” of his cell phone revealed a negative personal opinion on Trump and the Trump administration. www.lemonde.fr/internationa...

I think it's important to reach out to your own community and explain what the funding cuts mean in practice.

📢Aujourd'hui l'Institut Pasteur se mobilise pour la science, l'inclusion & l'avenir du savoir avec l'organisation du symposium «Excellence Scientifique : et si l'inclusion était la clé ?» en écho avec la Journée Internationale des Droits des Femme & la participation au mouvement #StandUpForScience !