Liisa Galea

Dr Munmun Choudhury on the major paradigm shifts in mental health care/research… are we ready for the 4th paradigm shift. Does AI have a role to play? And how to challenges (I.e. access to care) create barriers to progress? The social ecology is imp. Are the algorithms sensitive enough?

Up next for @camhnews.bsky.social research day is Tristan Glatard on promises and pitfalls of AI for neuroscience. Two broad ways of using AI. Predictive models and conversational agents.

Amy Diehl holding a paperback copy of GLASS WALLS

Hot off the press! Just got my copy of GLASS WALLS in paperback. Release date is Dec 11, along with audiobook format. Preorder here: amy-diehl.com/book

Closing Central Madrid To Cars Resulted In 9.5% Boost To Retail Spending, Finds Bank Analysis City of Madrid significantly boosted the takings of its shops and restaurants last Christmas by banning cars from the CBD, finds an analysis by Spain's second largest bank.

Keep this in mind when people claim cars mean business — closing Central #Madrid to cars over holidays resulted in a 9.5% boost in retail spending on its main shopping street: STUDY.

There was also a 71% drop in air pollution.

Via @carltonreid.com in @forbes.com. #citymakingmath #citiesforpeople

Gotta say, it’s a hard time to be a historian of medicine whose focus was pre-antiseptic / pre-vaccine era.

lol.

Goodbye San Diego! Thank you @sfn.org for another great meeting & exciting science! In the future, I hope to see more progressive work on sex/gender & critical #WomensHealth - related factors -ovarian cycle, menopause, pregnancy- featured in lectures & symposia! See you next year! #SfN25

Interested in how the gut microbiome influences mood, and hormones?? What should you eat to keep your gut microbiome happy? What’s different about men vs women’s gut microbiome? Please give this episode a listen. It’s full fibrey-richness.. 😉 🧄🧅🍌🍐➡️🧠⚕️

Reue: Sex and gender differences in CVD. There are known differences in disease pathology for atherosclerotic plaques with thicker fibrous caps, more collagen but less lipids in women/females. Which is recapitulated in mouse models!! With both goner and chromosome effects. Super cool.

Similar findings in humans! With drop in omega3 FA. and reduced mitochondrial respiration but only in women/females (using ipsc).

reue: Statin adverse side effects larger in women for diabetes and myopathy. These effects are recapitulated in mice!! See how studying sex can increase translation???!! Omega 3 FA may offset these side effects through mitochondrial function.

Reue: Same genes are conserved in humans. The Kdm5c allele shoes dose dependent side effects on fat depots and mitochondrial thermogenesis.

Karen Reue: Using the 4 core genotype and other models: 2XX gain more rapidly on a HFHC diet than those with a Y. There is also more sc fat depots. Are those genes that escape X inactivation responsible?

She drives the point home that gonads and XX/XY/XO/XXY complement influence health across the lifespan & are important throughout the body not just for reproductive reasons.

Dr Karen Reue’s Ori Rotstein Lecture for IMS at U Toronto - on why she studies sex differences. Look at those differences in serum metabolites, gene expression and all thing adipose related

He Vowed to “Protect the Unborn.” Now He’s Blocking a Bill to Expand Medicaid for Wisconsin’s New Moms. Splitting with anti-abortion members of his own party, Wisconsin Assembly Speaker Robin Vos has refused to join 48 other states in ensuring that vulnerable women have access to potentially lifesaving ...

In 48 other states, new moms have access to Medicaid for up to one year after they give birth. Not in Wisconsin.

There, the limit remains two months. And it’s only because of one man: Assembly Speaker Robin Vos.

By @megomatz.bsky.social

Methodology

The consequences of misinformation are real and often tragic #vaccines #measles www.nature.com/articles/d41...

Rodent vs human brain development (& hormone profiles) so important to understand. And one way to do this is to use hiPSCs from humans to create organoids (3D) vs 2D cultures of NPCs, neurons etc. neural organoids can be used as a model system to study brain development @ncndgroup.bsky.social

Early gene expression does show sex differences across the brain using postmortem tissue. In addition, fetal testosterone peaks 14-16w during gestation in males -does this contribute?

Prevalence and treatment responses differ by sex. Over time the treatment response to antipsychotics improves in males but not females 🤯. These findings suggest it’s fruitful to look at sex as a factor. Sex hormones and chromosomes play a role.

Deepak is giving us some lessons learned from working with organoids and studying males and females as well as how estrogens influence human development. @ncndgroup.bsky.social How & do the mechanisms of glutamergic neurons develop differ between males and females?

Follow along for highlights from Deepak’s talk @ncndgroup.bsky.social

The speaker at the lectern

Title slide

After the lunch break, we will have several short presentations, chaired by Annie Butler
First, Ian Harris with 'The varying use of randomisation in “randomised” trials included in systematic reviews in orthopaedic surgery'
Lots of clinical studies are done very poorly.
#IRICSydney

Very glad to share our newest paper published in Molecular Psychiatry: Investigating milk-derived extracellular vesicles as mediators of maternal stress and environmental intervention www.nature.com/articles/s41... fun collab w/ @jordanmarrocco.bsky.social. Please enjoy! #OpenAccess #MaternalHealth

Introducing the 𝐏𝐈-𝐚𝐭-𝐜𝐨𝐧𝐟𝐞𝐫𝐞𝐧𝐜𝐞 𝐒𝐥𝐚𝐜𝐤 𝐦𝐨𝐝𝐞! 🤯

When activated, it will auto-reply to your PI's frantic ideas for new experiments, analyses, and projects with "Great suggestion! Saving this for later" (aka: let's talk when you’re back and got some sleep)

#sfn2025 #sfn25

I’m not sure who needs to hear this but RCTs are a tool in our scientific tool kit. It’s a powerful tool but things “go wrong” in RCTs with randomization, primary outcomes (yes you can do secondary analyses), intention to treat etc. RCTs, prospective, observational all have a role to play in science

Perimenopause: An understudied transition for the brain We know little about the mechanisms underlying well-known perimenopause symptoms in the brain. More research—in animals and humans—is essential.

Many well-known perimenopause symptoms arise in the brain, but we still know little about the specific mechanisms at play. More research—both in animals and humans—is essential, writes @kundakoviclab.bsky.social.

#neuroskyence

www.thetransmitter.org/sex-hormones...

For those exoplanet explorers: all you wanted to know about WASP-121b. Direct from kid #1. Precise Constraints on the Energy Budget of WASP-121 b from Its JWST NIRISS/SOSS Phase Curve
doi.org/10.3847/1538...
via @ioppublishing.bsky.social