Korolchuk Lab

Ho ho ho, happy Sunday egg-ficionados! Here is another great issue of #cebooc: biomed.news/bims-cebooc/...

Highlight: pubmed.ncbi.nlm.nih.gov/41241715/
Runner-up: pubmed.ncbi.nlm.nih.gov/41271398/

Thanks @biomednews.bsky.social for preselecting!

Good Sunday, all. What a great week for #cancermetabolism and #mitochondrialbiology. Find here a selection of groundbreaking discoveries: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading

"Trying to define yourself is like trying to bite your own teeth."-Alan Watts

#SfRBM25 is starting with an extensive discussion on the future of #redox biology. Looks like the field is very much alive and kicking, and it’s going to be a great meeting!

🧠🔬 Postdoc positions open!
The MAP team at the IINS in beautiful Bordeaux is looking for curious and independent researchers to study how neuronal synapses work, adapt, and change at the molecular and cellular levels.

More about the offers 👉 shorturl.at/4KoxR
More about the team 👉 shorturl.at/lzFmN

a woman is laying on her stomach in the leaves reading a book . ALT: a woman is laying on her stomach in the leaves reading a book .

#Autophagy and #mTOR papers from last week, enjoy thanks to @biomednews.bsky.social pre-selection!

biomed.news/bims-auttor/...

🚨Reposts appreciated‼️If I had read this PhD offer five years ago, I wouldn’t have hesitated for a second to apply 😉
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨

#PhD #3DGenome

#Autophagy and #mTOR papers from last three weeks, enjoy!

biomed.news/bims-auttor/...

biomed.news/bims-auttor/...

biomed.news/bims-auttor/...

Looking forward to presenting and discussing our data, and making new friends of course!

In cells I would say Halo-GFP-Su9 as its pulse-chaseable so gives more precise quantification compared to Keima. In mice still MitoQC. In humans nothing to my knowledge.

This week's selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...

highlight: Role of AAA-ATPase Cdc48p in peroxisomal quality control www.cell.com/cell-reports...

Good Sunday, mitolovers! 🌟 Exciting news in the world of #cancermetabolism and #mitochondrialbiology! 🧬 Check out the papers from last week here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading📚

"Knowledge is an unending adventure at the edge of uncertainty."-Jacob Bronowski

a young man wearing a hoodie that says you don t wanna miss it ALT: a young man wearing a hoodie that says you don t wanna miss it

A strong effort by the #autophagy and #mTOR field last week, lots of interesting published papers in the link below 👇🏼

biomed.news/bims-auttor/...

q.e.d Science Critical Thinking AI for constructive criticism and science evaluation

Here's the link to the system, try it! qedscience.com
@qedscience.bsky.social

Ubiquilin-2 liquid droplets catalyze α-synuclein fibril formation | The EMBO Journal imageimageFibril formation of α-synuclein is central to Parkinson’s disease (PD) pathology. This study shows that UBQLN2 droplets catalyze α-synuclein fibrillization via their liquid-gel/solid transition, while a small molecule targeting UBQLN2 ...

Proud to be involved in this great paper describing a novel mechanism of #synuclein aggregation with implications for potential #PD treatment, don’t miss it! 👇🏼👇🏼👇🏼
Congratulations to the team!

www.embopress.org/doi/full/10....

This week's selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...

Highlight: A genome-to-proteome map reveals how natural variants drive proteome diversity and shape fitnes www.science.org/doi/10.1126/...

Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations Mitochondrial synthesis of adenosine triphosphate is essential for eukaryotic life but is dependent on the cooperation of two genomes: nuclear and mitochondrial DNA (mtDNA). mtDNA mutates ~15 times as...

Fresh selection of papers on #MitochondrialDisease from #week41! 📚 💚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social

Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations
www.science.org/doi/10.1126/...

Good Sunday, all. Your weekly curated summary of papers in #cancermetabolism and #mitochondrialbiology is ready, don't miss it as it is full of exceptional discoveries: biomed.news/bims-camemi/... Biomed News #keepreading

"To see takes time, like to have a friend takes time." -Georgia O'Keeffe

#Autophagy and #mTOR paper published last week, lots of cool stuff, enjoy!

biomed.news/bims-auttor/...

Great to see it worked at the end, well done, Michele! You definitely confirm the rule that activity on science social media accounts correlates with the number and impact of first author publications, a lesson to many others aspiring for an academic career. Many congratulations again!

Congrats, super cool! 👏🏼👏🏼👏🏼

Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations Mitochondrial synthesis of adenosine triphosphate is essential for eukaryotic life but is dependent on the cooperation of two genomes: nuclear and mitochondrial DNA (mtDNA). mtDNA mutates ~15 times as...

How can mitophagy be an effective quality control mechanism if mtDNA mutations reach high enough levels to cause disease?

This question led us into a dark path, full of concepts of evolutionary genetics, germline stem cell biology and mito-nuclear compatibility.

www.science.org/doi/10.1126/...

Investigating the ageing-Parkinson’s disease nexus: standardisation of in vitro models and techniques by the PD-AGE network npj Parkinson's Disease - Investigating the ageing-Parkinson’s disease nexus: standardisation of in vitro models and techniques by the PD-AGE network

A new set of guidelines on the use of in vitro models in #PD and #Ageing research #Justpublished, don’t miss it! 👇🏼👇🏼👇🏼

rdcu.be/eKanG

Scripps is conducting a tenure track assistant professor search. This is a broad search across multiple departments for outstanding individuals that could integrate into the multi-disciplinary environment at Scripps Research. All interested should apply! Please share. apply.interfolio.com/174756

This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...

Highlight: Translation landscape of stress granules www.science.org/doi/10.1126/...

DDHD2 provides a flux of saturated fatty acids for neuronal energy and function - Nature Metabolism Saber et al. show that the lipase DDHD2 provides endogenous saturated fatty acids to support fatty acid oxidation and energy production, proteostasis and membrane trafficking balance.

#MitochondrialDisease papers from #week40! 📚 💚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

A few highlights below! 👇

DDHD2 provides a flux of saturated fatty acids for neuronal energy and function
www.nature.com/articles/s42...

a woman in a red and white striped shirt is throwing papers into the air ALT: a woman in a red and white striped shirt is throwing papers into the air

#Autophagy and #mTOR papers from last week, enjoy thanks to @biomednews.bsky.social pre-selection engine. DM them if you want your own personalised feed.

biomed.news/bims-auttor/...

Ribonucleotide incorporation into mitochondrial DNA drives inflammation - Nature Imbalanced nucleotide metabolism leads to age- and mtDNA-dependent inflammatory responses and senescence-associated secretory phenotype in senescence.

#MitochondrialDisease papers from #week39! 📚 👇
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social

A few highlights below!

Urolithin A ameliorates the age-dependent decline of ER-mitochondria contacts and alters intracellular Ca2+ balance.

In this week's issue of mitophagy news 🪫🗑️:

-Urolithin A increases healthspan via MERCS and Ca2+-mitophagy
-Parkin Induces Ubiquitination and Large Extracellular Vesicle Release of HMGB1 to Activate Antitumor Immunity
-a Parkin and hTau mouse cross

biomed.news/bims-tofagi/...

Ive Been Doing A Bunch Of Research Mitchell Moffit GIF ALT: Ive Been Doing A Bunch Of Research Mitchell Moffit GIF

#Autophagy and #mTOR papers from last 4 weeks, buildup due to laziness but lots of cool stuff here, have a look!

biomed.news/bims-auttor/...

biomed.news/bims-auttor/...

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Amino acid–dependent TSC2 dephosphorylation by lysosome–PP2A regulates mTORC1 signaling transduction The mammalian target of rapamycin complex 1 (mTORC1) signaling pathway, composed of amino acid (AA)–sensing (Ragulator/LAMTOR-Rag) and growth factor (GF)–sensing (AKT-TSC1/2-Rheb) axes, pivotally regu...

And another amazing #mTOR paper👇🏼Where do people get strength from to put so much work into this?

www.life-science-alliance.org/content/8/11...