Korolchuk Lab

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This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...

Highlight: Translation landscape of stress granules www.science.org/doi/10.1126/...

DDHD2 provides a flux of saturated fatty acids for neuronal energy and function - Nature Metabolism Saber et al. show that the lipase DDHD2 provides endogenous saturated fatty acids to support fatty acid oxidation and energy production, proteostasis and membrane trafficking balance.

#MitochondrialDisease papers from #week40! 📚 💚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

A few highlights below! 👇

DDHD2 provides a flux of saturated fatty acids for neuronal energy and function
www.nature.com/articles/s42...

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#Autophagy and #mTOR papers from last week, enjoy thanks to @biomednews.bsky.social pre-selection engine. DM them if you want your own personalised feed.

biomed.news/bims-auttor/...

Ribonucleotide incorporation into mitochondrial DNA drives inflammation - Nature Imbalanced nucleotide metabolism leads to age- and mtDNA-dependent inflammatory responses and senescence-associated secretory phenotype in senescence.

#MitochondrialDisease papers from #week39! 📚 👇
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social

A few highlights below!

Urolithin A ameliorates the age-dependent decline of ER-mitochondria contacts and alters intracellular Ca2+ balance.

In this week's issue of mitophagy news 🪫🗑️:

-Urolithin A increases healthspan via MERCS and Ca2+-mitophagy
-Parkin Induces Ubiquitination and Large Extracellular Vesicle Release of HMGB1 to Activate Antitumor Immunity
-a Parkin and hTau mouse cross

biomed.news/bims-tofagi/...

Ive Been Doing A Bunch Of Research Mitchell Moffit GIF ALT: Ive Been Doing A Bunch Of Research Mitchell Moffit GIF

#Autophagy and #mTOR papers from last 4 weeks, buildup due to laziness but lots of cool stuff here, have a look!

biomed.news/bims-auttor/...

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Amino acid–dependent TSC2 dephosphorylation by lysosome–PP2A regulates mTORC1 signaling transduction The mammalian target of rapamycin complex 1 (mTORC1) signaling pathway, composed of amino acid (AA)–sensing (Ragulator/LAMTOR-Rag) and growth factor (GF)–sensing (AKT-TSC1/2-Rheb) axes, pivotally regu...

And another amazing #mTOR paper👇🏼Where do people get strength from to put so much work into this?

www.life-science-alliance.org/content/8/11...

mTORC1 senses glutamine and other amino acids through GCN2 | The EMBO Journal imageimageDuring starvation, individual amino acid levels are thought to be relayed via distinct metabolic sensors, but how mTORC1 senses glutamine remains unclear. This study finds that GCN2 kinase acts as a unifying module in suppression of ...

#mTOR research field never ceases to amaze, what a tour de force! 👇🏼

mTORC1 senses glutamine and other amino acids through GCN2 | The EMBO Journal www.embopress.org/doi/full/10....

Structural basis for the dynamic regulation of mTORC1 by amino acids - Nature Using cryo-electron microscopy, the interactions of Sestrin2 and CASTOR1 with GATOR2 were resolved, revealing how mTORC1 activation is regulated and how nutrient availability triggers signalling for c...

www.nature.com/articles/s41...

Proteomic aging signatures across mouse organs and life stages | The EMBO Journal imageimageGenomic and transcriptomic studies have advanced our system-level understanding of aging, but large-scale proteomic analyses of the underlying processes remain limited. This resource provide...

Proteomic aging signatures across mouse organs and life stages | The EMBO Journal www.embopress.org/doi/full/10....

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#mTOR and #autophagy papers from last week. Lots of interesting new stuff, enjoy thanks to @biomednews.bsky.social pre-selection!

biomed.news/bims-auttor/...

a cartoon chef holding a piece of paper that says me when reading an article and its very good ALT: a cartoon chef holding a piece of paper that says me when reading an article and its very good

Good Sunday all! There is another beutifully exciting selection of papers in #cancermetabolism and #mitochondrialbiology waiting for you here: biomed.news/bims-camemi/... Biomed News #keepreading

"Things take the time they take. Don't worry."

Mary Oliver

Reconstitution of BNIP3/NIX-mitophagy initiation reveals hierarchical flexibility of the autophagy machinery - Nature Cell Biology Adriaenssens et al. show that unlike soluble cargo receptors, transmembrane cargo receptors initiate autophagosome biogenesis by recruiting the FIP200/ULK1 or WIPI–ATG13 complex, revealing unexpected ...

🍹@martenslab.bsky.social @elias-adriaenssens.bsky.social & co show that, unlike soluble, transmembrane cargo receptors initiate autophagosome biogenesis by recruiting the FIP200/ULK1 or WIPI–ATG13 complex, revealing unexpected flexibility in the selective #autophagy machinery.
bit.ly/4lpGh9P

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Just finished selecting the top novel computational and analytical methods for small molecule analysis.

biomed.news/bims-metlip/...

A collaboration with @Bims_BiomedNews

This week's selection of articles and many #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...

a man sitting on a bench reading a book with the words this is what i 'm doing at the moment ALT: a man sitting on a bench reading a book with the words this is what i 'm doing at the moment

Good Sunday all. A wonderful selection of papers in #cancermetabolism and #mitochondrialbiology is waiting for you. Check it here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading

"Our plans never turn out as tasty as reality."-Ram Dass

an illustration of a bird holding a stack of books with reading time written above it ALT: an illustration of a bird holding a stack of books with reading time written above it

#Autophagy and #mTOR papers from last week, not the usual abundance but worth keeping an eye on. Thanks to @biomednews.bsky.social for the reliable service!

biomed.news/bims-auttor/...

This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...

Highlight: Diffusing protein binders to intrinsically disordered proteins www.nature.com/articles/s41...

a cartoon character standing in front of the word science ALT: a cartoon character standing in front of the word science

Good Sunday, all. This week was a blast for @cancermetabolism and @mitochondrialbiology. Don't miss the curated issue of papers, check it here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading

"There was another life that I might have had, but I am having this one."-Kazuo Ishiguro

a woman in a red dress says " read honey " ALT: a woman in a red dress says " read honey "

#Autophagy and #mTOR papers from last week, lots of cool stuff, enjoy!

biomed.news/bims-auttor/...

Phosphoribosyl ubiquitination of SNARE proteins regulates autophagy during Legionella infection | The EMBO Journal imageimageAmong the hundreds of proteins that are secreted by Legionella pneumophila (the causative agent of Legionnaires’ disease) during infection, the SidE class of effectors modify host proteins b...

www.embopress.org/doi/full/10....

Structure of human mitochondrial pyruvate carrier MPC1 and MPC2 complex The Mitochondrial Pyruvate Carrier (MPC) bridges cytosolic and mitochondrial metabolism by transporting pyruvate into mitochondria for ATP production and biosynthesis of various essential molecules. M...

Structure of human mitochondrial pyruvate carrier MPC1 and MPC2 complex - PMC
pmc.ncbi.nlm.nih.gov/articles/PMC...

Mitochondrial Donation in a Reproductive Care Pathway for mtDNA Disease | NEJM Pathogenic variants in mitochondrial DNA (mtDNA) are a common cause of severe, often fatal, inherited metabolic disease. A reproductive care pathway was implemented to provide women carrying pathog...

#MitochondrialDisease collection of papers from #week30! 📚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

Mitochondrial Donation in a Reproductive Care Pathway for mtDNA Disease | New England Journal of Medicine
www.nejm.org/doi/10.1056/...

#ER_literature

an illustration of a bird holding a stack of books with reading time written above it ALT: an illustration of a bird holding a stack of books with reading time written above it

Good Sunday all. A beautiful selection of papers in #cancermetabolism and #mitochondrialbiology is ready for you here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading

"If your eyes are blinded with your worries, you cannot see the beauty of the sunset." - Jiddu Krishnamurti

This week's selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight: PERK and IRE1α promote exosome secretion via blocking lysosomal degradation of multiple vesicular body #JBC www.jbc.org/article/S002...

Happy Sunday! A new issue of #cebooc is here, check it out!

biomed.news/bims-cebooc/...

Highlight: pubmed.ncbi.nlm.nih.gov/40696105/ on the metabolic regulation of embryogenesis

Thanks @biomednews.bsky.social for preselecting!

an illustration of a bird holding a stack of books with reading time written above it ALT: an illustration of a bird holding a stack of books with reading time written above it

#Autophagy and #mTOR papers from last week, as always pre-selected by @biomednews.bsky.social, enjoy!

biomed.news/bims-auttor/...

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#Autophagy and #mTOR papers from past two weeks, some interesting stuff, don’t miss it!

biomed.news/bims-auttor/...

biomed.news/bims-auttor/...