Mona Alzheimer

© Bayerische Staatskanzlei

Today, Minister-President Markus Söder awarded @jorg-vogel-lab.bsky.social the Bavarian Maximilian Order. Presented every two years, the award recognizes outstanding accomplishments in science & the arts and is regarded as one of the state’s highest honors. Congrats on the “Bavarian Nobel Prize”! 👏🎉

Structures of the bacterial flagellum of Salmonella enterica

#MicrobiologyMonday: The bacterial flagellum is built through a hierarchical assembly process and powered by a dynamic motor capable of astonishing speeds. What's new in our understanding of these complex nanomachines? Find out in #MMBRJournal: asm.social/2HB

Open-Source Developer for Deep Learning Antibiotic Discovery Platform - Research Introduction Antimicrobial resistance (AMR) is one of the most urgent global health threats projected to cause up to 10 million deaths per year by 2050. The AI4AMR project brings together teams from I...

If you're interested in developing an open-source image analysis platform/plugin to profile bacteria with deep learning while living in the beautiful city of Paris 🇫🇷, check out this job ad from the @chzimmer.bsky.social lab @pasteur.fr

research.pasteur.fr/fr/job/open-...

Check this out! A napari plugin for AI-based analysis of microbial bioimages! 🔬🦠💻

🦠🔬🤖🧑‍💻 #mAIcrobe is out! With @pinholab.bsky.social's lab, we launched an open-source framework for high-throughput bacterial image analysis. By rockstars A. Brito & B. Saraiva et al, making #DeepLearning for phenotyping accessible! Easy to use, plus model training

📜 www.biorxiv.org/content/10.1...

What an incredible weekend at the kickoff meeting of the @zeit.de #Zia programme for #VisibleWomenInScience. Deeply grateful to the organisers and the many inspirational women, who shared their stories and energy. Looking forward to the fellowship year ahead with this exceptional group of women!!!

JB Editor's Choice: Waller, Ribardo & Hendrixson show that flagellar length impacts function, with short flagella slowing swimming and reducing host colonization, indicating the important of regulating the lenght of the filament.
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology

Von links nach rechts: Markus Blume, Patrick Cramer, Markus Söder, Simone Schwanitz und Hubert Aiwanger

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Die Bayerische Staatsregierung und die @maxplanck.de wollen den Wissenschaftsstandort Würzburg stärken. Ein heute unterzeichnetes Memorandum of Understanding legt den Grundstein für den Ausbau der Forschung in der Biomedizin. Auf eine starke Partnerschaft!
📸 Axel Griesch

Are you interested in studying RNA phages? We are looking for a PhD student and a postdoc to join the lab!

For more information and how to apply, see below 👇

Please RT!

BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)

Glucose capping of 5'-mRNAs in E. coli 😱, presumably is installed during transcriptional initiation #MicroSky #RNASky www.pnas.org/doi/10.1073/...

Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.

Disruption to the gut microbiome by non-antibiotics is linked to infection risk http://dlvr.it/TN9lNG

Looking for a new approach to studying or eliminating phages? Check out our study introducing anti-phage ASOs (antisense oligos) out in @Nature today. nature.com/articles/s4158…

PhDs & Postdocs of @uni-wuerzburg.de struggling to finish a project? Join our Long Night Against Procrastination!

✅ Tips on motivation & writing
✅ Pizza & plenty of coffee
✅ Work through the night with peers from all disciplines

📅 Oct 23, 2025 | 5pm–midnight
📍 Graduate Schools Building

PIRT-Seq: a high-resolution whole-genome assay to identify protein-coding genes Abstract. The advent of high-density mutagenesis and data-mining studies suggest the existence of further coding potential within bacterial genomes. Small

Out yesterday. Using a translation reporter on a mini-tn5 transposon, and high freq. mutagenesis, we looked at translation on whole genome scale independently of genome annotation. academic.oup.com/nar/article/...

1/16 New pre-print from the Sternberg Lab!
We uncover how temperate phages can use RNA-guided transcription factors to remodel the flagellar composition of their bacterial host and enhance their fitness.
Find the preprint and full story here: tinyurl.com/mshwjd77

Systematic screen uncovers regulator contributions to chemical cues in Escherichia coli Transport machineries are crucial for antibiotic resistance, but their regulation by external cues is poorly understood. This study identifies environmental chemicals that regulate transporter transcr...

Finally out! A small screen helps understand a little more about how E. coli regulates major transporters, and reveals how caffeine induces phenotypical antibiotic resistance. Huge thanks to collab @andrenmateus.bsky.social (Umeå) and Christian L. Müller (Munich)!
journals.plos.org/plosbiology/...

Left: Compound-promoter interaction network. Fifty-three significant compound-promoter interactions are shown as edges in a Sankey diagram connecting the compounds (left, source nodes) to the promoters (right, target nodes). Edge thickness represents mean Z-scores (n = 8), while node size represents the total number of interactions. Right: Proposed model for the molecular mechanism of caffeine-ciprofloxacin antagonism. Caffeine triggers expression of MicF small RNA in a Rob-dependent manner, which then binds to the 5′-UTR of ompF mRNA to inhibit and decrease OmpF protein levels. This ultimately prevents ciprofloxacin from entering the cell, resulting in caffeine-ciprofloxacin antagonism

How are bacterial transport machineries regulated by external cues? @brochadolab.bsky.social &co identify environmental chemicals that regulate #transporter transcription, identifying the TF Rob as a key modulator of #EffluxPump expression in #Ecoli #AMR @plosbiology.org 🧪 plos.io/46pUM9Q

🧪We are hiring #MicroSky🧪
Postdoc position in #microbiology #bioinformatics for our @volkswagenstiftung.de funded MOMENTUM project. Join us to study bacterial gene expression with #microfluidics and #microscopy.
➡️ www.uni-wuerzburg.de/fileadmin/03290000/2025/Postdoc_MOMENTUM_Sharma_2025-08.pdf

🎉 Congratulations to @angelifriedmann.bsky.social‬ on receiving an @erc.europa.eu Proof of Concept grant! With his project “SulFex”, he is working on a new strategy for treating a specific form of lung cancer #ERCPoC 📷Andreas Heddergott go.uniwue.de/poc-grant-an...

In situ structure of a bacterial flagellar motor at subnanometre resolution reveals adaptations for increased torque - Nature Microbiology In situ cryoEM and modelling of the Campylobacter jejuni flagellar motor characterize the periplasmic scaffold and the structural basis for increased torque generation.

#NewResearch

🚨Out now

In situ sub-nanometre structure of the Campylobacter jejuni flagellar motor revealing the periplasmic scaffold and basis for torque generation @beebylab.bsky.social

#MicroSky🦠🧫

www.nature.com/articles/s41...

Evolution of hunt, kill, devour in a Vibrio ecospecies Bacterial ecospecies are a recently recognized genetic structure that is hypothesized to arise by complex adaptation to a new niche. Using coadaptation analysis as a foundation for laboratory experime...

Happy to share the preprint from here in Shanghai, together with @danielfalush.bsky.social, as well as with team Zhizhou Jia, Huqi Wen, and Zhe Xie!

www.biorxiv.org/content/10.1...

Low-input RNA-seq suggests metabolic specialization underlying morphological heterogeneity in a gut commensal bacterium Isogenic bacteria can be phenotypically diverse. This heterogeneity is evident in the Bacteroidota, a predominant phylum of the human gut microbiota. …

The study was published in the journal @cp-cellreports.bsky.social‬: www.sciencedirect.com/science/arti...

A scalable gut epithelial organoid model reveals the genome-wide colonization landscape of a human-adapted pathogen - Nature Genetics A genome-wide screen using human gut epithelial organoids combined with transposon-directed insertion sequencing identifies over 100 Shigella flexneri genes required for epithelial colonization.

New study with an organoid model uncovering the role of tRNA modifications and codon usage in Shigella infection 🦠 #rnasky #microsky 💫💫 www.nature.com/articles/s41... Congrats @mldm.bsky.social

BPoD | Into the Nucleoid Into the Nucleoid - Biomedical pictures for April 2025.

Into the Nucleoid:

Single-molecule localisation 🔬 and live-cell imaging reveal fine details of chromosomal organisation in the bacterium E. coli 🦠

@michriscopy.bsky.social @uni-wuerzburg.de @heilemannlab.bsky.social @goetheuni.bsky.social
#microbiology

Freude über den Doppelerfolg: Zwei Würzburger Forschungsvorhaben haben sich im Exzellenzwettbewerb durchgesetzt und erhalten Mittel aus der begehrten Millionenförderung. Von links: Caroline Kisker (Würzburger Koordinatorin von NUCLEATE und Vizepräsidentin), Cynthia Sharma (Würzburger Speakerin von NUCLEATE), Ralph Claessen (Würzburger Speaker von ctd.qmat) und Universitätspräsident Paul Pauli (Bild: Jonas Blank / JMU)

Erfolg auf ganzer Linie: zwei Exzellenzcluster für Würzburg! 🥂🚀
Im Rahmen der #ExStra wird nicht nur der Quantenphysik-Cluster ctd.qmat weiterhin gefördert. Mit NUCLEATE, einem Forschungsprojekt zu Nukleinsäuren, kommt noch ein zweiter Cluster hinzu!
➡️ go.uniwue.de/xstra25

Map of Germany with the Clusters of Excellence

The #ClustersOfExcellence have been selected: today, the Excellence Commission approved 70 projects for funding. 45 clusters will continue and 25 will be newly established. Funding starts on 1 Jan 2026 for 7 years, with €539 million per year. The full list: www.dfg.de/resource/blo... 1/3

With great sadness and deep regret, we have to inform you that our department director and highly esteemed colleague Philippe Bastiaens @maxplanck.de passed away suddenly and unexpectedly on 15th of May.

The cartoon illustrates how single-cell transcriptomics works: all mRNA molecules are recorded and characterized from countless bacterial cells, which are shown here in survival size on a conveyor belt through the laboratory. - Copyright Scigraphix

Analysing the gene activity of every single bacterial cell in a colony? A new technique of single-cell transcriptomics developed in Würzburg can do this much more efficiently than other methods....
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