NNF Center for Basic Metabolic Research

Looking for a Postdoc position? (great program with 3-year funding and running costs)

@clemmensenc.bsky.social has a fantastic project in wonderful Copenhagen at the fantastic @cbmr.science research center

Being a program alumni I can can highly recommend the program and the Clemmensen lab :)

Commentary by Researcher @itsmedipsikha.bsky.social on the emerging role of glycogen metabolism in regulating energy homeostasis in adipose tissue is out now on @natrevendo.nature.com @cbmr.science

www.nature.com/articles/s41...

After an immensely enriching and rewarding PhD in @caina89.bsky.social lab at @pioneercampus.bsky.social, I am excited to announce that I moved to beautiful Copenhagen for my postdoc in Simon Rasmussen's group @cbmr.science!

Kickstart your research career in Copenhagen with a PhD or Postdoctoral fellowship at CBMR!

Four PhD and four Postdoc positions are currently available:

cbmr.ku.dk/join-us/fell...

#phdposition #postdocposition

🔎 𝐃𝐞𝐜𝐢𝐩𝐡𝐞𝐫𝐢𝐧𝐠 𝐭𝐡𝐞 𝐆𝐈𝐏 𝐩𝐚𝐫𝐚𝐝𝐨𝐱

Why does activating the GIP receptor contribute to weight-loss, given the evidence that blocking the receptor ought to be more effective?

Prof. Jens Juul Holst outlines the evidence in Diabetes 👇

diabetesjournals.org/diabetes/art...

#GIP #GLP1 #biotech #obesity

Safety becomes more important than foraging when a specific neuronal circuit in the brain is activated Researchers from the University of Copenhagen have identified a neural circuit in the mouse’s brain which ensures that it prioritises safety over other needs, e.g. food seeking, and that this happens ...

Scientists from @cbmr.science and the @ucph.bsky.social Department of Neuroscience have identified a neural circuit in the mouse’s brain that prioritises safety over other needs. The findings were published in @nature.com Neuroscience.

Read more, below 👇

healthsciences.ku.dk/newsfaculty-...

Insulin- and exercise-induced phosphoproteomics of human skeletal muscle identify REPS1 as a regulator of muscle glucose uptake Skeletal muscle glucose uptake, essential for metabolic health, is regulated by both insulin and exercise. Using phosphoproteomics, we analyze skeleta…

Insulin- and exercise-induced phosphoproteomics of human skeletal muscle identify REPS1 as a regulator of muscle glucose uptake
Great collaboration with @adeshmukh.bsky.social @JeppeKjaergaard.bsky.social and team @cbmr.science

www.sciencedirect.com/science/arti...

Insulin- and exercise-induced phosphoproteomics of human skeletal muscle identify REPS1 as a regulator of muscle glucose uptake Skeletal muscle glucose uptake, essential for metabolic health, is regulated by both insulin and exercise. Using phosphoproteomics, we analyze skeleta…

New publication!

We mapped the phosphoproteomic landscape of insulin & exercise in human skeletal muscle (same individuals) and discovered REPS1 as a new regulator of muscle glucose uptake.

www.sciencedirect.com/science/arti...

@cbmr.science @jeppekjaergaard.bsky.social

Body Fluid Proteomic Landscape of Acute Exercise Physical activity improves health, yet the molecular mechanisms remain partially understood. This study presents a high-resolution, time-resolved atlas profiling 10,127 proteins across plasma, saliva,...

Preprint Alert
We present the most comprehensive, time-resolved atlas of the human proteomic response to acute exercise. We mapped 10,000+ proteins across plasma, saliva & urine—3,000+ changed after just one workout.
doi.org/10.1101/2025...
Explore cbmr-rmpp.shinyapps.io/exerome/

Special day for our group @cbmr.science as we celebrate the successful defense of our (first) freshly minted PhD, Dr. Conchita Bringas 🥳 Her thesis was based on characterizing novel #AMPK inhibitors. Special thanks to the great committee @rbdamgaard.bsky.social ,Dave Carling & Lykke Sylow.

Thrilled to share that our manuscript mapping proteomic & phosphoproteomic signatures of NGT, T2D, males & females — before and after hyperinsulinemic-euglycemic clamp — is now accepted in Cell.

@annakrook.bsky.social @juleenrzierath.bsky.social
@cbmr.science

doi.org/10.1016/j.ce...

Promotional graphic for the 61st EASD Annual Meeting, taking place from 15–19 September 2025 in Vienna, Austria. The background is red with a white Ferris wheel illustration on the right-hand side. At the top left, the EASD 2025 Vienna logo is displayed. Large blue text reads “61st EASD Annual Meeting” with event dates and location beneath. In the centre-left, a blue and white banner highlights the “Rising Star Award” recipient, Dr. Jens Lund. To the right, there’s a circular photo of Dr. Jens Lund, a man with short light brown hair, wearing a black and white striped shirt, smiling against a light grey background. At the bottom left is the EASD logo, and the website easd.org appears at the bottom right.

🏆 Congrats Dr. Jens Lund (@cbmr.science &
& @ucph.bsky.social) for being awarded the EASD Rising Star Symposium & #EFSD Rising Star Fellowship for his research project: Circulating metabolites regulating energy homeostasis.

Looking forward to your #EASD2025 lecture & wish you continued success👏

CBMR spinout Ousia Pharma has secured significant seed funding from the Boston-based venture fund Omega Funds to support the preclinical and clinical development of a once-weekly, dual-incretin-NMDA receptor antagonist conjugate.

cbmr.ku.dk/news/2025/cb...

@clemmensenc.bsky.social

#biotech #glp1

Excited to share another great collaborative effort — we successfully combined single muscle fiber proteomics with functional assays in the same fiber! This integrated approach allows a direct link between molecular composition and functional performance at the single cell/fiber level.

Precision nutrition for cardiometabolic diseases - Nature Medicine This Review critically examines the evidence base in precision nutrition research, discusses the challenges in translating short-term studies into long-term clinical effectiveness and highlights the m...

Closing the week with exciting news! Our latest work, a review on #PrecisionNutrition for cardiometabolic diseases, has been published in @naturemedicine.bsky.social 😄

www.nature.com/articles/s41...

Precision nutrition for cardiometabolic diseases - Nature Medicine This Review critically examines the evidence base in precision nutrition research, discusses the challenges in translating short-term studies into long-term clinical effectiveness and highlights the m...

🥗 🎯 @martaguasch1.bsky.social & @jmerino.bsky.social release a Review in @nature.com Medicine on precision nutrition for cardiometabolic disease, examining the evidence base, exploring the potential benefits, and discussing the challenges and opportunities ahead. 👇

www.nature.com/articles/s41...

Incretin-based therapeutics for the treatment of neurodegenerative diseases Neurodegenerative diseases (NDDs) represent a heterogeneous group of disorders characterized by progressive neuronal loss, which results in significant deficits in memory, cognition, motor skills, and sensory functions. As the prevalence of NDDs rises, there is an urgent unmet need for effective therapies. Current drug development approaches primarily target single pathological features of the disease, which could explain the limited efficacy observed in late-stage clinical trials. Originally developed for the treatment of obesity and diabetes, incretin-based therapies, particularly long-acting GLP-1 receptor (GLP-1R) agonists and GLP-1R–gastric inhibitory polypeptide receptor (GIPR) dual agonists, are emerging as promising treatments for NDDs. Despite limited conclusive preclinical evidence, their pleiotropic ability to reduce neuroinflammation, enhance neuronal energy metabolism and promote synaptic plasticity positions them as potential disease-modifying NDD interventions. In anticipation of results from larger clinical trials, continued advances in next-generation incretin mimetics offer the potential for improved brain access and enhanced neuroprotection, paving the way for incretin-based therapies as a future cornerstone in the management of NDDs. This Review summarizes preclinical and clinical evidence highlighting the potential of incretin-based drugs as treatments of neurodegenerative diseases, such as Alzheimer’s disease or Parkinson’s disease.

REVIEW | A Vear, MT Heneka and @clemmensenc.bsky.social
( @cbmr.science , @umasschan.bsky.social )

Review on the potential of incretion-based drugs as treatments of neurodegenerative diseases

NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging Nicotinamide adenine dinucleotide (NAD) is a ubiquitous electron carrier essential for energy metabolism and post-translational modification of numero…

Latest from Jonas Treebak and team @cbmr.science

NAD depletion in skeletal muscle does not compromise muscle function o... www.sciencedirect.com/science/arti...

NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging NAD depletion in skeletal muscle does not impair tissue integrity and function or accelerate aging, as shown in a mouse model with an 85% decrease in muscle NAD+ levels. Muscle structure, metabolism, ...

In @cp-cellmetabolism.bsky.social: Mice retained normal muscle function and health even though their NAD+ levels were reduced by 85%. Given that NAD levels drop by only up to 30% through ageing, the findings challenge the health benefits claimed by supplement companies.

www.cell.com/cell-metabol...

Kan vi blive bedre til at forebygge type 2-diabetes – mere præcist og personligt?
I dag var jeg i TV2 News for at kommentere på det store danske studie DELPHI fra @cbmr.science , som følger 10.000 danskere i 25 år for at generere ny viden om precision health.
🧵1/4
#dkforsk #type2diabetes

Postdoctoral fellowships in proteogenomics of obesity and cardiometabolic disease We are looking to hire two highly motivated and dynamic Postdocs with a PhD or equivalent doctorate to join the Novo Nordisk Foundation Center for Basic Metabol

The Loos Group is offering two Postdoctoral fellowships in proteogenomics of obesity and cardiometabolic disease.

Read more about the positions, below 👇

candidate.hr-manager.net/ApplicationI...

New research in @nature.com Medicine by
@martaguasch1.bsky.social investigates the relationship between what we eat in midlife and the chances of reaching old age with good physical, cognitive, and mental health and without chronic diseases.

cbmr.ku.dk/news/2025/ea...

The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research - Nature Metabolism This broad group of authors summarizes the impact of circadian factors on metabolic biology and offers recommendations on how to account for and report biological, environmental and experimental facto...

The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research | Nature Metabolism
Great collaboration led by Satchin Panda and team! Happy to contribute.
Time to take timing into consideration!!
www.nature.com/articles/s42...

Speaker Spotlight: Zach Gerhart-Hines @zgerharthines.bsky.social
Join us @ #AdiposeBiology Conference in Montreal🇨🇦, Aug 19-20, 2025, to hear about homeostatic control!

🔗Register: adiposebiology.com

#ABC2025 @sablesys.bsky.social @beaudrj.bsky.social @mcgill.ca @uoft.bsky.social @cbmr.science

Congratulations to Amanda Bæk who successfully defended her PhD thesis "Mechanisms of Growth Hormone Induced Fibrosis in Human Adipose Tissue" today at Steno Diabetes Center Aarhus.

Thanks to @camillascheele.bsky.social from @cbmr.science and Jørgen Jensen for a thorough evaluation 🙏

If you haven't already signed up for the #Genomic Mechanism of Disease conference in Copenhagen May 19th - 23rd please consider! Deadline March 15th!

Amazing lineup of speakers and as always incredible venue, organisation and food.

sciencecluster.dk/event/genomi...

And that’s a wrap! 🥂

A huge thanks to everyone who joined us at Metabolism Day 2025 - whether you travelled from abroad, tuned in online, or nipped across the city. The talks were inspiring, the questions were thought provoking and the poster presentations exciting. 🚀

We hope to see you next year!

Fascinating talk by Prof Gregory Radick bringing new light on the debate between Mendelian v/s Weldonian theories of inheritance and genetics. The talk highlighted the importance of re-evaluating and contextualizing the history of science during public outreach.
#MD25 @cbmr.science

Post lunch session was kick started with a fantastic talk by Dr. James Trevaskis @elilillyandcompany.bsky.social taking us on a journey about the promising current and future #obesity therapeutics. #MD25 @cbmr.science

Metabolism Day 2025 is on! Join in online now:
www.youtube.com/live/oUi9JU_...

Today's Program: eventsignup.ku.dk/metabolismda...

@cbmr.science