Vikram Paralkar's Avatar

Vikram Paralkar

@paralkarlab.bsky.social

Physician-Scientist | University of Pennsylvania | Pol I, rRNA, Ribosomes, Chromatin, Transcription | Hematopoiesis and Leukemia | πŸ©ΈπŸ”¬πŸ§ͺ🧬 https://paralkarlab.med.upenn.edu

2,612 Followers  |  826 Following  |  614 Posts  |  Joined: 11.09.2023
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Posts by Vikram Paralkar (@paralkarlab.bsky.social)

Terrible! How is starving US science consistent with any kind of meaningful policy goal?

28.02.2026 16:18 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
An intrinsically disordered region mediates RNA-binding selectivity and cellular activities of LARP6 - Nature Communications LARP6 is an EMT-associated RNA-binding protein with diverse RNA targets. Here, the authors show that the N-terminal disordered region of LARP6 promotes RNA-binding selectivity by modulating the adjace...

πŸŽ‰Proud to present our latest paper, out now in Nature Communications: www.nature.com/articles/s41...

RNA Binding Proteins (RBPs) are often full of intrinsically disordered regions (IDRs), but what these regions do during RNA recognition is often unclear. 1/10
#RNA #IDR #RBP

21.02.2026 23:31 β€” πŸ‘ 74    πŸ” 33    πŸ’¬ 1    πŸ“Œ 4

@science.org A small polymerase ribozyme that can synthesize itself and its complementary strand | Science www.science.org/doi/10.1126/... #RNA #ribozyme #evolution

14.02.2026 20:35 β€” πŸ‘ 32    πŸ” 8    πŸ’¬ 1    πŸ“Œ 1

Here, we propose to measure the concentration of aerosolized particles of love.

We will use a novel detector sensitive to 1 ppm and calibrated to a wide dynamic range.

Our work seeks to definitively establish whether, indeed, as long-speculated, love is in the air today.

#HappyValentinesDay

14.02.2026 13:10 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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a pink calendar shows the date of february 14 ALT: a pink calendar shows the date of february 14

I accept you with minor revisions.

14.02.2026 12:02 β€” πŸ‘ 60    πŸ” 18    πŸ’¬ 2    πŸ“Œ 0
A decorative mirror hanging on a white wall. The mirror resembles the primary mirror from the James Webb Space Telescope. The mirror is seen almost straight on.

A decorative mirror hanging on a white wall. The mirror resembles the primary mirror from the James Webb Space Telescope. The mirror is seen almost straight on.

A decorative mirror hanging on a white wall. The mirror resembles the primary mirror from the James Webb Space Telescope. The mirror is seen from the side.

A decorative mirror hanging on a white wall. The mirror resembles the primary mirror from the James Webb Space Telescope. The mirror is seen from the side.

It took some doing, but I finally finished it: the coolest mirror on the planet!

(Sorry @esawebb.org.web.brid.gy, hanging out at a Lagrange point is a disqualifier, I don't make the rules)

11.02.2026 00:20 β€” πŸ‘ 28    πŸ” 1    πŸ’¬ 3    πŸ“Œ 0

IF ONLY! My Anatomy final exam would have gone so much better! 😭

05.02.2026 22:25 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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a man in a suit and tie stands in a room ALT: a man in a suit and tie stands in a room

Me at the "Journal of Advances in Agronomy and Crop Science"

04.02.2026 00:15 β€” πŸ‘ 5    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Totally in line with my expertise and not spam at all!

04.02.2026 00:11 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 2    πŸ“Œ 0
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Dr. Pavan spent decades studying rare diseases at NIH. Today, he’s battling one: first diagnosed with MDS-RARSt and, later, myelofibrosis. A stem cell transplant from his son saved his life, made possible in part by NIH-funded research. Learn more: https://ow.ly/XaWp50XXqtu

#Fight4Hematology

29.01.2026 15:00 β€” πŸ‘ 3    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

πŸ‘πŸΌπŸ‘πŸΌπŸ‘πŸΌ

02.02.2026 18:28 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

This just in. So honored and grateful...

02.02.2026 18:24 β€” πŸ‘ 175    πŸ” 18    πŸ’¬ 25    πŸ“Œ 0

Would you feel comfortable sharing your biosketch (I could also email you my work-in-progress document)? I'm at the gathering-ideas phase right now, and am not entirely sure what's permitted vs not...

01.02.2026 18:22 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

I have the same question: The instructions says "There is no specific format for referencing the products in this section" and then also says "Do not provide citations on the NIH Biographical Sketch Supplement." πŸ˜΅β€πŸ’« #confused

01.02.2026 18:06 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

I'm particularly unclear about how to cite papers in the "Contributions to Science" section. Any ideas, @ernstlaboratory.bsky.social or others?

01.02.2026 18:05 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 3    πŸ“Œ 0

Are any of you happy with how your ScienCV-generated biosketch looks? I'm not quite satisfied with mine (formatting, flow, etc), and would love to look at other examples for customization ideas! Please message me if you'd be willing to swap biosketches (confidentially, of course)!

01.02.2026 16:36 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Oh wow, I didn't realize that that was the name of the restaurant! I thought you were just naming an item on the menu! πŸ˜‚

31.01.2026 19:47 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Thanks! Which restaurant?

31.01.2026 19:40 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Wait where?!?

31.01.2026 19:28 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Love to see insights arising from unique and fascinating analyses of existing massive datasets! πŸ˜€

28.01.2026 17:28 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Credit where credit is due! NCBI helpdesk replied a week after my initial request, and merged my two accounts. I can now make my ScienCV Biosketch!

27.01.2026 16:13 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

If this nation has a conscience, what will it take to shake it from its slumber?

25.01.2026 21:32 β€” πŸ‘ 3    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
ASH Scholar Award Recipients View past ASH Scholar Award recipients.

www.hematology.org/awards/award...

23.01.2026 19:59 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Congratulations to Aishwarya Pawar (@aishwarya2510.bsky.social), @cambupenn.bsky.social PhD graduate from our lab, for the 2025 Kadesch Prize in Genetics. This award, in honor of Tom Kadesch (former chair of @penngenetics.bsky.social) honors graduate student excellence in research & citizenship.

23.01.2026 19:57 β€” πŸ‘ 5    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0

Congratulations to Charles Antony (@cantony07.bsky.social), Research Associate in our lab, for being awarded a 2026 American Society of Hematology (ASH) Fellow to Faculty Scholar Award for his investigations into ribosomal RNA transcription in hematopoiesis! Many thanks to ASH for this honor! #ASH

23.01.2026 19:51 β€” πŸ‘ 9    πŸ” 2    πŸ’¬ 2    πŸ“Œ 1
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a close up of a cartoon character 's face making a funny face ALT: a close up of a cartoon character 's face making a funny face
22.01.2026 17:53 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

😭

18.01.2026 17:26 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Just realized that the glitches I'm having with ScienCV are because I have two NCBI accounts... My ORCiD is linked to the obsolete acct, which means that I can't link it to my current acct... I've send a message to NCBI support desk to merge accts, and I hope they are staffed enough to respond...

17.01.2026 13:04 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 1
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Portrait of @nobelprize.org laureate Carol Greider for the @nationalacademies.org.

Alongside her mentor Elizabeth Blackburn, Dr Greider identified telomerase, an enzyme that maintains the protective caps at the ends of chromosomes known as telomeres.

More: explorers.com/carol-grieder/ #SciArt

16.01.2026 14:00 β€” πŸ‘ 27    πŸ” 5    πŸ’¬ 0    πŸ“Œ 1