Vikram Paralkar

who decided to call it Secret Santa when Nondisclosure Claus was right there

I'm not sure it says anything about liquidity at all.

Someone asked me if I'd found the cure for cancer yet ! 😭😵

Oh I'm obsessed with the show, and have followed it closely since it's launch! It's a must-watch.

I've been making small donations to Wikipedia for many years. Given the enormous service that it provides to all of us, it's in our collective interest to keep it smoothly running.

Take my posts for what they are: My recollection of what a senior scientist in the field had to say about LLPS. (5/5)

He speculated that these low complexity/disordered domains were driving specific but low-affinity interactions to form mesh-like or stacked-beta-pleat structures (but not oil-water droplets with LLPS properties), and what the field needs now are better structures. (4/x)

...he never believed that such gels or droplets were actually being formed within the cell. He seemed quite annoyed by the way in which in vitro "droplet" assays have been used to draw sweeping conclusions about the manner in which these proteins were supposedly functioning in live cells... (3/x)

...at how in vitro assays have been used in this field. He showed old data from his lab of how some low complexity domains associated to produce jello-like cubes in vitro, and he said that while the ability to form gels reflected some aspect of the biochemistry of those proteins... (2/x)

I'm not a biophysicist and have no particular dog in this LLPS fight, but I can share an anecdote. A few years ago, Steven McKnight of UTWS, who got the Lasker this year for his work on disordered domains, gave a talk at our Penn Epigenetics Inst symposium. He sounded genuinely IRATE... (1/x)

The fact that this happened in a Nature Press journal is concerning. How could such an obviously gibberish-filled figure get through an editor...?

The paper now has this note:

Listening to Bach and marveling, just marveling, at the fact that such music exists on this earth.

Awesome story, Mia! Congratulations!

I now know how antigens feel... 😅

Most of us wouldn't be able to tell that this blot is fake! We're headed towards a topsy-turvy future. 😵‍💫

For 40+ years, the ASH Scholar Award has helped jumpstart careers in hematology—funding 678 awards, $82M in research, and $3B in follow-on funding. Learn more: https://bit.ly/4idJLvV

#ASHAwards

a man is hugging a michelin mascot in front of a sign for spark plugs ALT: a man is hugging a michelin mascot in front of a sign for spark plugs

Why did I never before realize that the Michelin that gives ⭐stars⭐ to restaurants for exquisite dining is the same puffy Michelin dude who sells tyres?!?

Ah I see. I'll read your paper in more detail to look into QC for Nanopore calls of 6mA. Thank you for these references!

Thanks for this! Could you perhaps point me to references that could help me understand this in more detail? Specifically, the RNA salvage or RNA-DNA hybrid point that you mentioned - do they actually produce 6mA on DNA itself (or do they just cause erroneous calls by Nanopore)?

Super interesting! Could I ask how confident we are that 6mA on DNA is not present in, say, mammals? Is it absolutely completely absent (because the methyltransferase doesn't even exist)? Or is it present at low and insignificant levels that are not physiologically relevant?

Step 1: Don't own any bitcoin.

It's so difficult to "score" applicants for our PhD and MD/PhD program this year - they are all so accomplished, eloquent, intelligent, and driven! My recommendation: Recruit them all! 😁

Hope this terrible law isn't passed by Congress...

Seriously, what are they thinking? If even this election result cannot give the Dems a spine, then we're lost...

😂

😭😭😭

In the movie theater, when that scientist in Prometheus tried to pet a cobra-like hissing alien as through it were a kitten, I remember thinking, "Why do scriptwriters keep giving us these unbelievably moronic scientists who are just begging for horrific deaths...?"

No. No. Absolutely not. The ethics of primate research are complicated enough already. Please DO NOT bring back Homo erectus or some other extinct human ancestor!

Mutations in mitochondrial rRNA are recurrently observed in cancers! 😳🤯

Our latest paper has just been published in Cell!

doi.org/10.1016/j.ce...

We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.