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Kilchert lab

@kilchertlab.bsky.social

We are an RNA biology lab @JLU Giessen interested in RNA quality control, RNP remodelling and post-transcriptional gene regulation - branching into chromatin

196 Followers  |  323 Following  |  5 Posts  |  Joined: 30.12.2024  |  1.9471

Latest posts by kilchertlab.bsky.social on Bluesky

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πŸ“£ Our lab is looking for a PhD student to join us in exploring RNA biology! Details in the announcement. Feel free to reach out with any questionsβ€”and please RT!

25.03.2025 20:00 β€” πŸ‘ 8    πŸ” 12    πŸ’¬ 0    πŸ“Œ 1
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Postdoc in Structural Biology of RNA processing complexes Postdoctoral positions in structural biology of macromolecular complexes are available in the laboratory of Dr. Eva Kowalinski at the EMBL Grenoble, France. We are looking for highly motivated and amb...

Postdoc positions in structural biology of RNA processing complexes.

An ERC-funded position will dissect pre-mRNA processing pathways in the infective organism Trypanosoma brucei. An ANR-funded position will characterise large complexes in RNA modification.

Details: tinyurl.com/postdoc-RNA-...

17.07.2025 09:50 β€” πŸ‘ 21    πŸ” 19    πŸ’¬ 0    πŸ“Œ 1
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#Postdoc position - at the University of Marburg (Germany), funded within our ERC Advanced Grant "C-SWITCH"

Focus: CTP-dependent molecular switches as a new principle of cellular regulation in bacteria (including bacteriophages)

Apply by 04 May: stellenangebote.uni-marburg.de/jobposting/2...

02.04.2025 15:39 β€” πŸ‘ 38    πŸ” 34    πŸ’¬ 1    πŸ“Œ 2
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Anne Spang awarded distinction of AAAS Fellow The AAAS has elected Prof. Anne Spang at the Biozentrum, University of Basel, as a Fellow. With this honor, the world’s largest scientific society recognizes her outstanding contributions to the field...

Congratulations to Anne Spang @spanglab.bsky.social for being elected as a new #AAASFellow by @aaas.org ! The world’s largest scientific society recognizes her outstanding contributions to the field of cell #biology and #biochemistry. @unibas.ch
www.biozentrum.unibas.ch/news/detail/...

28.03.2025 08:17 β€” πŸ‘ 44    πŸ” 9    πŸ’¬ 0    πŸ“Œ 1

I'm excited to share our latest publication on co-transcriptional RNA folding in a eukaryote! Great work by Leo SchΓ€rfen with collaboration from Isaac Vock and Matt Simon! @leoschaerfen.bsky.social @mattdsimon.bsky.social
Take a peek here authors.elsevier.com/a/1kpxo_Oylr...

26.03.2025 12:12 β€” πŸ‘ 26    πŸ” 5    πŸ’¬ 2    πŸ“Œ 1
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A nearly 9 year effort to design and implement new CLIP-based technologies to define multimeric protein assemblies on RNA.

Enables β€˜watching’ of RNP assemblies inside living cells

Special congrats to Luca Ducoli, Brian Zarnegar, and Paul Khavari @nature.com
www.nature.com/articles/s41...

26.03.2025 17:40 β€” πŸ‘ 156    πŸ” 58    πŸ’¬ 3    πŸ“Œ 0
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RNA Salon in mRNA Translation

We have an exciting lineup with Keynote by: Marvin Tanenbaum (Hubrecht/ Delft)

Please RT
@goetheuni.bsky.social @cpi-exstra.bsky.social

24.03.2025 06:57 β€” πŸ‘ 15    πŸ” 10    πŸ’¬ 3    πŸ“Œ 0
Postdoctoral Researcher Our research is focused on understanding how genetic changes in the non-coding genome can impact gene regulatory mechanisms, alter developmental processes and ultimately affect human craniofacial shap...

πŸ“£ We are advertising for a postdoc to join our team at the University of Edinburgh! Our lab studies gene regulatory mechanisms in development, and how genetic changes may impact these processes to alter development and shape human craniofacial form and function 🧬πŸ§ͺ

20.03.2025 09:22 β€” πŸ‘ 66    πŸ” 55    πŸ’¬ 6    πŸ“Œ 2
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The nuclear exosome co-factor MTR4 shapes the transcriptome for meiotic initiation Nature Communications - Nuclear RNA decay regulates gene expression in cultured cells, but its role in animals is largely unclear. Here, authors found that the nuclear exosome co-factor MTR4...

Cool! #MTR4 #RNADecay #RNA #RNAExosome
The #nuclear #exosome co-factor #MTR4 shapes the #transcriptome for #meiotic initiation

Li Zhang, Jianshu Wang, Zhidong Tang, Zhen Lin, Ruibao Su, Naijing Hu, Yao Tang, Gaoxiang Ge, Jing Fan, Ming-Han Tong, Yuanchao Xue, Yu Zhou & Hong Cheng
rdcu.be/ed5WM

18.03.2025 21:08 β€” πŸ‘ 9    πŸ” 4    πŸ’¬ 1    πŸ“Œ 1
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Nuclear and genome dynamics underlying DNA double-strand break repair - Nature Reviews Molecular Cell Biology Changes in nuclear and genome organization promote the repair of DNA double-strand breaks and genome stability. Processes that are involved include the modulation of chromatin state, condensates of re...

✨New online!✨

@altmeyerlab.bsky.social, @karimmekhail.bsky.social et al. discuss how DNA double-strand break repair is modulated by nucleus and genome reshaping through chromatin state, condensates of repair proteins, and cytoskeleton reorganization.

πŸ”— go.nature.com/3DBSVCP

18.03.2025 08:35 β€” πŸ‘ 16    πŸ” 7    πŸ’¬ 0    πŸ“Œ 1

Super proud! Congrats and well done!

07.03.2025 09:16 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Congratulations to RTG2355-member Jennifer Kothe from Elena Evguenieva-Hackenberg's lab for successfully defending her dissertation - well done, Jenni! πŸŽ“πŸ₯³

(And please note the DNA, RNAP, RNA and ribosome on the cake!)

28.02.2025 10:17 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Early posttranscriptional response to tetracycline exposure in a gram-negative soil bacterium reveals unexpected attenuation mechanism of a DUF1127 gene The Gram-negative, soil-dwelling plant symbiont Sinorhizobium meliloti shares its free-living habitat with antibiotic producers. To learn about early steps of its adaptation to antibiotics, we analyze...

Excited to share the work of Jennifer Kothe et al suggesting a mechanism to be used by bacteria for fine-tuning gene expression according to ribosome availability and translation efficiency: www.biorxiv.org/content/10.1...

28.02.2025 11:56 β€” πŸ‘ 0    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

Open PhD position in our RTG2355 - great diversity in topics, invited speakers, retreats and symposia, workshops, soft skill courses - and very nice people!

28.02.2025 13:00 β€” πŸ‘ 2    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
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The impact of the RNA exosome on ribosome specialisation in different cell types at Newcastle University on FindAPhD.com PhD Project - The impact of the RNA exosome on ribosome specialisation in different cell types at Newcastle University, listed on FindAPhD.com

We have a 4 year PhD position available to study the impact of the RNA exosome on ribosome specialisation! Get in touch if you are interested or just apply. March 31st deadline.

www.findaphd.com/phds/project...

04.03.2025 19:16 β€” πŸ‘ 7    πŸ” 5    πŸ’¬ 0    πŸ“Œ 0
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Postdoc positions in Nuclear RNA Biology - Ledig stilling pΓ₯ Aarhus Universitet Ledig stilling ved Institut for MolekylΓ¦rbiologi og Genetik - RNA-biologi og -innovation, Aarhus Universitet

Second call for a postdoc position in my lab. Please read more and apply here: mbg.au.dk/aktuelt/ledi...

04.03.2025 15:23 β€” πŸ‘ 8    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0
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An elevated level of the mRNA exporter Mex67-Mtr2 in nuclear mRNPs impairs nuclear mRNA export In eukaryotes, a crucial step in gene expression is the export of the mRNA out of nucleus. The conserved mRNA exporter Mex67-Mtr2 (NXF1-NXT1 in human) is a key factor in this process. In S. cerevisiae...

We are excited to share the work of Nataliia Stefanyshena who showed that maintenance of an optimal Mex67 level in nuclear mRNPs is required for efficient mRNA export: www.biorxiv.org/content/10.1...

28.02.2025 11:25 β€” πŸ‘ 2    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
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Doctoral student (m/f/d) in the field of RNA Biology

Interested in RNA biology, especially mRNA processing and export from nucleus to cytoplasm? We are looking for an enthusiastic PhD student to investigate the RNA-binding proteins Sub2 and Tho1 πŸ§ͺπŸ§«πŸ”¬

More details and instructions on how to apply: www.uni-giessen.de/de/ueber-uns...

28.02.2025 12:36 β€” πŸ‘ 7    πŸ” 7    πŸ’¬ 0    πŸ“Œ 1

Wolfgang! @wkhuber.bsky.social Read my slow analysis manifesto and join the slow analysis movement. Let's make data analysis healthy again!

27.02.2025 20:27 β€” πŸ‘ 22    πŸ” 10    πŸ’¬ 2    πŸ“Œ 0
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The rise and shine of yeast optogenetics

Full text: onlinelibrary.wiley.com/doi/10.1002/...

#yeast #saccharomyces #microbiology

27.02.2025 21:39 β€” πŸ‘ 18    πŸ” 7    πŸ’¬ 0    πŸ“Œ 0

This work is not only an amazing resource for the community, it is also a total masterclass in code reusability, data FAIRness and reproducibility. Hopefully, this is the future!

26.02.2025 16:58 β€” πŸ‘ 14    πŸ” 5    πŸ’¬ 0    πŸ“Œ 0
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Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability Losing parental histones during DNA replication fork passage challenges differentiation competence and cell viability.

𝐇𝐨𝐰 𝐝𝐨 𝐜𝐞π₯π₯𝐬 π«πžπ¦πžπ¦π›πžπ« 𝐰𝐑𝐨 𝐭𝐑𝐞𝐲 𝐚𝐫𝐞 𝐚𝐟𝐭𝐞𝐫 𝐃𝐍𝐀 𝐫𝐞𝐩π₯𝐒𝐜𝐚𝐭𝐒𝐨𝐧? Our new study β€œDisabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability” is out in 𝘚𝘀π˜ͺ𝘦𝘯𝘀𝘦 𝘈π˜₯𝘷𝘒𝘯𝘀𝘦𝘴. Led by @lleonie.bsky.social @biranalva.bsky.social 🧡 More belowπŸ‘‡

19.02.2025 19:35 β€” πŸ‘ 112    πŸ” 53    πŸ’¬ 5    πŸ“Œ 5

PhD position vacant in the lab. Please spread the news. Study topic: Mammalian nuclear RNA production and turnover systems. Learn more about the lab here: www.mRNP.au.dk

20.02.2025 09:53 β€” πŸ‘ 8    πŸ” 12    πŸ’¬ 0    πŸ“Œ 0
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A proteome-wide yeast degron collection for the dynamic study of protein function
Full text: rupress.org/jcb/article-...

#yeast #saccharomyces #microbiology

18.02.2025 15:27 β€” πŸ‘ 14    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0
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Cytoplasmic mRNA decay and quality control machineries in eukaryotes Nature Reviews Genetics, Published online: 27 January 2025; doi:10.1038/s41576-024-00810-1In this Review, Dowdle and Lykke-Andersen discuss advances in our understanding of the machinery and mechanisms involved in the control of cytoplasmic mRNA decay and…

FYI: New online! Cytoplasmic mRNA decay and quality control machineries in eukaryotes

17.02.2025 14:27 β€” πŸ‘ 19    πŸ” 5    πŸ’¬ 1    πŸ“Œ 0
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Not long until the deadline for this faculty position @dunnschool.bsky.social...

Are you the one to lead a group doing great research in a special environment, while teaching outstanding students?

www.path.ox.ac.uk/vacancy/asso...

17.02.2025 17:05 β€” πŸ‘ 18    πŸ” 18    πŸ’¬ 0    πŸ“Œ 0
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Pombase PomBase is the comprehensive model organism knowledgebase for the fission yeast Schizosaccharomyces pombe (S. pombe).

PomBase is GBC Global BioData Resource of the week www.linkedin.com/pulse/pombas...

17.02.2025 10:33 β€” πŸ‘ 11    πŸ” 6    πŸ’¬ 0    πŸ“Œ 0
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Come and join us for the RMU RNA salon "Translation" in Frankfurt! Tuesday, April 1st 2025, 12:30 – 6:00 pm at Medical Campus Niederrad, Building 22 – HS22-2.

Please register here: bit.ly/13_RMU_RNA_S...

Thank you @rnasociety.bsky.social and #lexogen for funding!

17.02.2025 12:01 β€” πŸ‘ 22    πŸ” 12    πŸ’¬ 0    πŸ“Œ 0
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We are recruiting! Center for Gene Expression has 2 or more open positions for PhDs @ucph.bsky.social. Come join our team to work on RNAPII and transcriptional regulation (gregersenlab.com). It's a wonderful city and amazing research environment. Deadline March 6. jobportal.ku.dk/phd/?show=16...

13.02.2025 20:09 β€” πŸ‘ 6    πŸ” 9    πŸ’¬ 0    πŸ“Œ 1
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We are pleased to announce registration for RNA 2025 - the 30th Annual Meeting of the RNA Society - is now open!
www2.rnasociety.org

This year’s meeting will be held at the beautiful Town and Country Resort & Convention Center in sunny San Diego, California, USA from May 27th - June 1st, 2025.

04.02.2025 22:48 β€” πŸ‘ 41    πŸ” 24    πŸ’¬ 1    πŸ“Œ 4

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