viroid

please let me know if you have any questions or ideas, I'd love to chat!

21.01.2024 17:40 — 👍 3    🔁 0    💬 0    📌 0

you can find the preprint here: www.biorxiv.org/content/10.1...

and all the data and analysis here: purl.stanford.edu/wb363nt3637

21.01.2024 17:38 — 👍 2    🔁 0    💬 1    📌 0

I really excited to continue studying these elements (and am looking for a place to do it!). I've already established a cell-Obelisk isolate system and will be looking into how these elements replicate, what Oblin-1 does, and what Obelisks do to their host physiology

21.01.2024 17:36 — 👍 5    🔁 0    💬 2    📌 0

Huge thanks to my co-authors: Robert C. Edgar, Maria Jose Lopez Galiano, Marcos De la Peña, Artem Babaian, Ami S. Bhatt, and Andrew Z. Fire for their invaluable help and support

21.01.2024 17:34 — 👍 3    🔁 0    💬 1    📌 0

A multi-panel diagram of features about "Obelisks". Top half, a) schematics of Obelisk-alpha, a 1164 nt long, apparent;y circular, predicted to be rod-shaped RNA that codes for two proteins, Oblin-1 and Oblin-2 where Oblin-1 is self-complementary. Obelisks bare no sequence similarity to any annotated genetic sequence. The predicted secondary structure is depicted as "Jupiter" plots (circular diagrams where chords represent predicted base pairs), and as skeleton diagrams (where parallel lines represent predicted base pairs). Bottom left, b) a schematic of the world map, with nations coloured in shades of red representing the number of datasets (from a subset database) that contain Obelisks (redder = more datasets), nations from all 7 continents are shaded. Bottom right, c) a predicted tertiary structure for Oblin-1, that appears to be a novel fold, represented as in cartoon format and as a topological diagram (right).

There's a ~1000nt sub-viral RNA that shows up on every continent, and in humans, and it seems to have gone unnoticed! It has no sequence similarity to any database and codes for a wacky protein

Super happy to finally share my thesis work on "Obelisks"

tinyurl.com/yc54fzj9

#MicroSky #microbiomesky

21.01.2024 17:32 — 👍 65    🔁 27    💬 2    📌 4

The mini fridge paradox — Homeworld Collective All life on earth, blue whales, rabbits, ants, bacteria, even TSA agents, is electrically powered. The powerhouse of the cell is just a warehouse where countless high-power electrons discharge energy ...

I wrote about some speculative microbial energetics for the Homeworld Ideas Challenge and placed fourth!

In it, I mused about how Cable Bacteria metabolism might be influenced by thermal gradients.

In short, any effect is likely small, but writing about it was fun!

t.ly/Pn8-E

#MicroSky

23.12.2023 03:21 — 👍 4    🔁 0    💬 1    📌 0

You mentioned you're looking for faculty opportunities: recruit.ucdavis.edu/JPF05986

10.09.2023 22:29 — 👍 2    🔁 1    💬 0    📌 0