Weichhart Lab @weichhartlab

Paul Ettel receives FSR Early Career Fellowship Grant | MedUni Vienna

and here is the press release from the university: www.meduniwien.ac.at/web/en/ueber...

17.07.2025 09:27 — 👍 1 🔁 0 💬 0 📌 0

Paul Ettel, MD-PhD student in the lab has been awarded a prestigious Early Career Fellowship Grant from the Foundation for Sarcoidosis Research (FSR). FSR will support Paul’s research on the role of neutrophils and arginine metabolism in granuloma formation in sarcoidosis. Congratulations!

14.07.2025 20:42 — 👍 6 🔁 1 💬 1 📌 0

We are grateful to the Austrian Science Fund @fwf-at.bsky.social for receicing a new standalone grant to study metabolic signaling in sarcoidosis!

08.07.2025 07:24 — 👍 2 🔁 0 💬 0 📌 0

The immunometabolic topography of tuberculosis granulomas governs cellular organization and bacterial control Despite being heavily infiltrated by immune cells, tuberculosis (TB) granulomas often subvert the host response to Mycobacterium tuberculosis (Mtb) infection and support bacterial persistence. We previously discovered that human TB granulomas are enriched for immunosuppressive factors typically associated with tumor-immune evasion, raising the intriguing possibility that they promote tolerance to infection. In this study, our goal was to identify the prime drivers for establishing this tolerogenic niche and to determine if the magnitude of this response correlates with bacterial persistence. To do this, we conducted a multimodal spatial analysis of 52 granulomas from 16 non-human primates (NHP) who were infected with low dose Mtb for 9-12 weeks. Notably, each granuloma’s bacterial burden was individually quantified allowing us to directly ask how granuloma spatial structure and function relate to infection control. We found that a universal feature of TB granulomas was partitioning of the myeloid core into two distinct metabolic environments, one of which is hypoxic. This hypoxic environment associated with pathologic immune cell states, dysfunctional cellular organization of the granuloma, and a near-complete blockade of lymphocyte infiltration that would be required for a successful host response. The extent of these hypoxia-associated features correlated with worsened bacterial burden. We conclude that hypoxia governs immune cell state and organization within granulomas and is a potent driver of subverted immunity during TB. ### Competing Interest Statement M.A. and S.B. are named inventors on patent US20150287578A1, which covers the mass spectrometry approach utilized by MIBI-TOF to detect elemental reporters in tissue using secondary ion mass spectrometry. M.A. and S.B. are board member and shareholder in IonPath, which develops and manufactures the commercial MIBI-TOF platform.

Preprint can be found here: www.biorxiv.org/content/10.1...

08.07.2025 07:06 — 👍 1 🔁 0 💬 0 📌 0

Spatial immunometabolic zonation in tuberculosis granulomas - Nature Reviews Immunology A preprint by McCaffrey and Delmastro et al. delineates distinct immunometabolic zones of tuberculosis granulomas and reports that hypoxia is a key driver of immune subversion.

Amitava Sinha via the @preprintclub.bsky.social‬ wrote a nice Journal Club article on a preprint by from the Angelo lab @stanfordmedicine.bsky.social that describes spatial immunometabolic zonation in tuberculosis granulomas: www.nature.com/articles/s41...

08.07.2025 07:06 — 👍 6 🔁 2 💬 1 📌 0

Anne Miller erhält FWF-ASTRA-Preis Mehr über ihre Forschungsarbeit!

Ausgezeichnet für ihre Forschungen zum #Zellstoffwechsel 💯

Wir gratulieren Anne Miller, Zentrum für Pathobiochemie und #Genetik der #MedUniWien, zur Auszeichnung mit dem FWF-ASTRA-Preis! Mehr über ihre Arbeit erfahren ⬇️

@fwf-at.bsky.social

26.06.2025 15:01 — 👍 15 🔁 3 💬 0 📌 1

Special thanks goes to the amazing SFB immunometabolism, which made this work possible, and of course the extraordinary, phantastic MEL team.

03.06.2025 14:22 — 👍 3 🔁 1 💬 0 📌 0

Supported by @microbesplanet.bsky.social
@medunigraz.at @fwf-at.bsky.social - Thank you!

03.06.2025 14:13 — 👍 4 🔁 1 💬 1 📌 0

📢 Big day for archaeal microbiology!

Today, we jointly shed light on the mysterious world of archaeal extracellular vesicles from human gut archaea - published in @natcomms.nature.com ‬ in parallel with our precious colleagues around @mkrupovic.bsky.social 🇦🇹🤝🇫🇷.

03.06.2025 14:13 — 👍 33 🔁 21 💬 1 📌 1

#msca #industry #business #marieskłodowskacurieactions #unionofskills… | Marie Skłodowska-Curie Actions Strengthening Europe’s research and innovation capacity also means investing in its researcher’s long-term careers. This is precisely the goal of the #MSCA…

www.linkedin.com/posts/mscact...

02.04.2025 20:50 — 👍 7 🔁 3 💬 0 📌 0

Proud to announce that we are one of the 149 out of 1417 successful applicants to be funded for a EU MSCA Doctoral Network! Looking forward to this big challenge coordinaring such an amazing network: UNLIMITED (UNderstanding Lipid ImmunoMetabolIsm To trEat Disease)

02.04.2025 20:43 — 👍 10 🔁 4 💬 2 📌 0

Particle uptake by macrophages triggers bifurcated transcriptional pathways that differentially regulate inflammation and lysosomal gene expression @cp-immunity.bsky.social
www.cell.com/immunity/ful...

21.03.2025 19:11 — 👍 21 🔁 9 💬 1 📌 0

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