Clinical & Experimental Immunology

🧪 Study shows Staphylococcus aureus exotoxin SEB can bind and activate the immune receptor 2B4, driving allergic inflammation. 2B4‑KO mice showed reduced inflammatory responses, suggesting 2B4 as a potential therapeutic target.

🔗 https://bit.ly/4my2B1e

🧬 Research shows newborn immunity differs sharply from adults: NK cells and ILCs are functionally mature at birth, while NKT‑like cells are far less abundant and less active. Important context for understanding early‑life infection risk.

🔗 https://bit.ly/3JfJag1

IFNγ from activated CD4⁺ T cells is a key driver of B‑cell differentiation and autoantibody production in IMQ‑induced lupus mice.

IFNγ deficiency dramatically reduced disease features, a promising immune pathway for future SLE therapies. https://bit.ly/4qs1hyZ

Highlighting this article that explores an alternative way of assessing mTOR inhibition therapy following kidney transplantation.

Read the article here: https://bit.ly/4kyQn9w

Celebrating #February11 by highlighting Professor Claudia Mauri, the Editor‑in‑Chief of @ceijournal.bsky.social Her leadership and expertise continue to shape the future of immunology.

Read the interview on the BSI website here: https://bit.ly/4abuedR

#WomenInScience

This #WorldCancerDay, explore how bispecific T‑cell engagers (BiTEs) could strengthen T‑cell responses against solid tumours, and the challenges still holding them back.

Read the open access review: https://bit.ly/4291Ipg

#CancerResearch #Immunotherapy #BiTEs

🔬Maria Filika & Stergios Katsiougiannis explore how salivary gland epithelial cells in Sjögren’s syndrome actively drive and amplify autoimmune responses, reshaping how we view target tissues in autoimmunity.

Read the open access review: https://bit.ly/4k6LOTH

📢 We’re welcoming high‑quality translational immunology submissions! If your research offers novel mechanistic insight into human disease, we want to hear from you.

Submit your work: https://bit.ly/3LjuI2A

🔬 Jan Devan et al. identify distinct pro‑inflammatory T‑cell populations in Crohn’s disease lesions, including CD4⁺CD39⁺ TCRαβ⁺ cells and activated TCR Vδ1⁺ cells, highlighting potential new therapeutic targets.

Read the article: https://bit.ly/3LitpGu

#CrohnsDisease

📘 See CEI’s top-performing papers of 2025!

Explore our 2025 must‑read articles, highlighting impactful immunology research

Read more: https://bit.ly/45ELeXc

MOG/NMDAR overlapping syndrome is increasingly recognised.

This review shows common symptoms (psychiatric changes, seizures), typical MRI patterns, good treatment response, but a notably higher recurrence rate.

Read here📄 https://bit.ly/3Q2S29A

Crohn’s disease lesions show enrichment of CD4⁺CD39⁺ TCRαβ⁺ TEM cells producing IL‑17/IL‑21 and terminally differentiated TCR Vδ1⁺ cells producing TNF‑α/IFN‑γ.

Distinct inflammatory roles point to Vδ1⁺ cells as a potential therapeutic target.

📄 https://bit.ly/3LitpGu

Despite elevated KLR and mitochondrial gene expression, Tregs in autoimmune PAI show normal frequency and suppressive function, suggesting limited involvement in disease pathogenesis.

📄 https://bit.ly/3Q2QVGU

Working in immunology?

Clinical & Experimental Immunology publishes impactful studies across six core sections plus areas like immunometabolism, mucosal immunity, and immunotherapy.

Learn more about submitting your next manuscript to CEI: https://bit.ly/443pf8s

Important CIDP research shows significant changes in circulating B‑cell subsets and elevated IL10/TNFA expression, correlating with disability scores and nerve fiber density. Valuable insights for understanding disease activity.

📄 https://bit.ly/3rzemhN

This study highlights 2B4 (CD244) as a key receptor driving Staphylococcus aureus–associated allergic inflammation. SEB binds and activates 2B4, amplifying eosinophil responses, pointing to a promising therapeutic target.

📄 https://bit.ly/4my2B1e

Happy holidays from all of us! ❄️✨

Thank you to our authors, reviewers, and readers for another great year. We look forward to welcoming your submissions in the new year!

🎧 CEI Wrapped!

A standout year for Clinical & Experimental Immunology!

Thank you to our authors, reviewers and readers for helping CEI grow its reach and impact in 2025.

person reading posters at BSI congress

Well done to the recipients of this year’s BSI journals-sponsored Poster Prizes! 🎉

Congrats to Flavio Beke, Aisling Newing & Rébecca Barascud for their brilliant contributions. 👏

Read more: https://bit.ly/3MljD6r

Attending #BSI25? Don't miss 'Immunology in the Balance' at 16:30 today. 🧬⚖️

See our very own Editor-in-chief Claudia Mauri discuss how immunity is regulated to stay effective & safe.

See the programme here: https://bit.ly/4a5iBp1

Attending #BSI25?📣 Don’t miss AI in Publishing with Rachel Moriarty from our publisher OUP.

Explore how AI is shaping journals, research integrity & ethical practice, plus tips for using AI responsibly as an author.

🗓 3 Dec 2025 | ⏰ 13:15–14:10 | 📍 Hall 1C

Attending #BSI25? 📣 Meet our Editor-in-Chief, Claudia Mauri!

Join us at the BSI stand this evening (18:00–19:30) in the exhibition hall to hear more about Immunology and Clinical & Experimental Immunology. Come say hello! 👋

🔬 New in the “Clinical & Experimental Treatment of…” series: residual immune activation persists in people with HIV on ART. This review explores strategies to reduce inflammation and guide future research.

📖 https://bit.ly/4g5VMm4

#HIV #Immunology #ART #WorldAIDSday

Rotavirus vaccines save lives, but CMV exposure may reduce responses in some infants. New research highlights this challenge in HIV-exposed, uninfected babies, underscoring the need for equity in early-life health.

📖 Learn more: https://bit.ly/3DX1oAq

#WorldAIDSDay #Immunology #ChildHealth

🦠 How do gut cells shape infections? This study, part of the Review Series - Organoids to Study Immune Cells Development and Function (Ed. Joana Neves), uses organoids to reveal how pathogens target specific cells!

🔬 Read more: https://bit.ly/422Z96U

#GutHealth #Organoids #InfectiousDiseases

🛡️ This #PublishingIntegrityWeek, BSI journals are tackling papermills, promoting AI transparency, DEI & accessibility, and supporting ethical research in immunology.

Read more 👉 https://bit.ly/4odyvAZ

💙 On #WorldDiabetesDay, explore new insights into immune regulation in childhood #T1D.

An Open Access study in Clinical & Experimental Immunology links Galectin-1 with inflammation & Treg cells in children with type 1 diabetes.

Read more 👉 https://bit.ly/4r3C2Vw

Tomorrow marks #WorldDiabetesDay, check out this Open Access study: a new LIPS assay detects zinc transporter 8 autoantibodies (ZnT8A) quickly, safely, and with minimal blood, helping identify children at risk for type 1 diabetes.

Read more 👉 https://bit.ly/3JBSPhw

🧫 Organoids reveal how gut epithelial diversity shapes host–pathogen interactions, enabling study of viruses, bacteria & parasites previously impossible in vitro.

👉 https://bit.ly/422Z96U

#Organoids #GutImmunology #Immunology

📘 People living with HIV can experience residual immune activation even on ART, raising comorbidity risks.

Krystelle Nganou-Makamdop reviews human studies on anti-inflammatory therapies and future strategies.

👉 https://bit.ly/4g5VMm4

#HIV #Immunology