Rolando Claure

🧬 In SGLT2-deficient 🐁 on a diabetogenic high-fat diet, kidneys had ↑ SAM → better function + ↓ NF-κB inflammation.
SAM donates methyl groups → ↑ H3K27 trimethylation → repression of inflammatory 🧬 . Blocking MAT2A removed protection.
🔗 jci.org/articles/view/188933

In cirrhosis, TIPS can boost kidney function & reduce ascites, but may worsen encephalopathy. MELD guides risk, yet misses post-TIPS creatinine gains.
👉 TIPS decisions should weigh kidney health, not MELD alone. #HRS #TIPS
🔗 pdfs.journals.lww.com/kidney360/99...?

🌿 Herbal medicine: tradition… but also risk.
Some plants are nephrotoxic and can injure the kidneys.

📖 In Tropical Nephrology 2025, we review mechanisms of kidney injury linked to medicinal plants.

🔗 link.springer.com/chapter/10.1...

#Nephrology #TropicalMedicine #KidneyHealth

RED IRA - Sociedad Latinoamericana de Nefrología e Hipertensión La RedIRA (Red Latinoamericana de Injuria Renal Aguda), es una iniciativa del Comité ...

🧩 La #EII (Crohn y colitis ulcerosa) no solo afecta al intestino: puede causar complicaciones renales graves.
La #IRA vinculada a EII incluye nefritis túbulo-intersticial (farmacos/MEI), NTA y glomerulopatías como NIgA.
🔗 Más en: slanh.net/redira
#SoySLANH

💔 In HF patients with loop diuretic resistance, therapy depends on mechanism (DR-Loop vs DR-Distal).

📊 JASN RCT (n=103):
• ↑ Loop dose → +49 mmol Na excretion
• + Chlorothiazide → +107 mmol Na excretion

👉 Thiazide add-on more effective overall.
journals.lww.com/jasn/abstrac...

In a secondary analysis of 7,562 Chinese adults with eGFR 60–90, intensive BP control reduced composite CVD outcomes by 43% vs usual care, with no significant difference in kidney function decline.
📖 JAMA Netw Open jamanetwork.com/journals/jam...

🌍 Apply for ISN Committees & Working Groups!
Make an impact on global kidney care. You can express an interest yourself or nominate a colleague.

⏳ Deadline: Oct 22, 2025, 5 p.m. CEST
👉 http://lite.spr.ly/6...

#ThisIsISN #ISNWCN

𝗧𝗢𝗗𝗔𝗬: SLANH-ISN webinar: "Fluids in AKI: New Paradigms."

🗣️ @runningkidneys.bsky.social, Lilia Rizo, Alejandro Ferreiro, Jonathan Chavez
👤 Olynka Vega
🗓️ October 1
🕓 7 pm Panama time
🔗 Free registration: bit.ly/slanh01octubre

Un muy buen 4to lugar en mi categoría #SendaDelSol ☀️ 🏃🏻 🔟 Km #Run4Kidneys 🫘 #850Challenge 🎗️

Metabolic dysfunction–associated kidney disease (MDAKD) links metabolic syndrome & CKD. Prevention must include early risk assessment, lifestyle change & novel therapies (SGLT2i, GLP-1RA).
👉 www.kidney-international.org/article/S008...

#KidneyHealth #CKD #MetabolicDisease

✅ PROGRAMA EDUCATIVO ANUAL DIALOGANDO CON EXPERTOS
👉 SLANH + ISN

🚀 Tema: FLUIDOS EN IRA: NUEVOS PARADIGMAS

🗓️ Miércoles 01 de octubre de 2025
🕖 19:00 Hs: 🇵🇦 PA
✅ REGISTRATE AQUI: bit.ly/slanh01octubre

🌐 slanh.net
#slanh #soynefrólogo #soyslanh

New study: In cirrhosis patients with AKI, a tubular secretion score helps differentiate ATN from PRA/HRS.
Lower secretion = ATN risk ↑ (OR 0.34 per SD; AUC 0.73).
Promising tool for diagnosis & prognosis.

journals.lww.com/cjasn/abstra...

#AKI #Hepatology

AI 🤖 is reshaping #nephrology: from patient summaries & pathology to dialysis optimization, AKI/CKD diagnosis, and transplant care.
@ASN_Kidney is preparing a position paper on responsible AI use, with major focus at #KidneyWk25 in Houston.
www.kidneynews.org/view/journal...

The Impact of Hemodiafiltration Versus Hemodialysis on Uremic Symptoms, Physical Function: A Systematic Review and Meta-analysis of Randomized Controlled Trials Uremic symptoms and frailty in kidney failure may be driven by the accumulation of uremic toxins that are variably cleared by dialysis. We conducted a systematic review and meta-analysis of…

📊 Of 1,226 studies screened, 24 RCTs (n=3,906) on HDF vs HD were analyzed.
🔹Most 4h, 3x/wk, post-dilution (15–24L effluent). Symptoms studied: cramps, fatigue, GI, itch, restless legs, sleep.
📑 Meta-analysis: HDF did not improve these vs HD. #HDF #HD

www.kidneymedicinejournal.org/article/S259...

#CochaTrail 21K ✅🏃🏻‍♂️ Stunning #Cochabamba views ⛰️ at 2890 m above sea level! A tough and demanding circuit 😅 #Run4Kidneys 🫘 #850Challenge

A Systematic Review Comparing the Prognostic Role of eGFR According to CKD-EPI and Older Age Validated Equations in Older Adults Assessing the clinical relevance of reduced estimated glomerular filtration rate (eGFR) in older adults is challenging as GFR naturally declines with age and not all equations, including the Chronic…

📉 In adults ≥65y, a systematic review (13 studies, >100k participants) found no difference in mortality risk prediction between CKD-EPI & older-age–validated eGFR equations.
Cystatin C–based eGFR showed stronger links with ☠️ than creatinine-based.
🔗 www.kidneymedicinejournal.org/article/S259...

Pig kidney transplants take a step forward with approval of human trials | CNN Scientists continue to make progress with research on how well pig organs might perform in humans, and now they’re ready for the next step: larger-scale clinical trials.

FDA has approved the first human clinical trials for pig-to-human kidney transplants—a major leap in xenotransplantation that could help solve the severe organ shortage and offer hope to millions waiting for transplants. #OrganTransplantation

www.cnn.com/2025/09/08/h...

𝗧𝗢𝗗𝗔𝗬: Grand Rounds in Transplant Nephrology – an ISN-TTS Sister Transplant Centers Initiative.

🗣️ Noot Sengthavisouk, Surasak Kantachuvesiri, Nuttapon Arpornsujaritkun
👤 Robert Freercks
🗓️ September 11
🕓 2 pm CEST
🔗 Free registration: http://lite.spr.ly/6...

🧪 New in #Kidney360: “Active” urine sediment (dysmorphic RBCs, casts) strongly predicts proliferative GN.
In 795 biopsies: sensitivity 82%, specificity 74%.
Simple, low-cost microscopy remains a powerful guide in #Nephrology.

🔗 journals.lww.com/kidney360/ab...

✨🙌 Damos la bienvenida a la nueva Junta Directiva SLANH 2025–2027. Felicitamos a sus integrantes y les deseamos el mayor de los éxitos en esta gestión que fortalece la unidad, la ciencia y la nefrología en América Latina. 🌎🩺💙 #SLANH #SaludRenal

Our 🆕 prospective cohort study (n=120) shows that pre-operative standardized phase angle (SPhA) > –0.54 is linked to significantly ⬇️ incidence of #AKI after cardiac surgery: 21 % vs 40 % (P=.072), and milder AKI—8 % vs 30 % (P=.029) 👉🏻 Medicine journals.lww.com/md-journal/f...

Honored to be elected Vice President of Latin America Society of Nephrology and Hypertension (SLANH) Region 3 during the #SLANH2025 Congress in Guayaquil 🇪🇨.
A privilege to serve and work alongside colleagues to strengthen nephrology in our region. 🌎🫘🩺

#TodosSomosSLANH

Social Deprivation as a Key Driver of Spatial Disparities in End-Stage Kidney Disease Incidence AbstractBackground. Despite France's universal healthcare system, significant geographic disparities in the incidence of end-stage kidney disease (ESKD) pe

Social deprivation is the main driver of disparities in ESKD incidence in 🇫🇷 , explaining ~35% of spatial variability—more than diabetes or access to care. Even with universal healthcare, addressing #SDoH is key to reducing kidney disease burden. #ESKD
doi.org/10.1093/ckj/...

Buenos días #KidneyRunners 🏃🏻‍♂️ a comenzar el último día del Congreso #SLANH2025 creando conciencia sobre la #EnfermedadRenal #Run4Kidneys 🫘 #850Challenge

After a successful #AKI workshop at @SLANH_ Nephrology and Hypertension Conference Let’s raise awareness of #KidneyDisease 🫘 #Run4Kidneys 🏃🏻‍♂️ #850Challenge #Guayaquil 🇪🇨 #SLANH2025

Discover the winners of the 2026 ISN Awards! - International Society of Nephrology

Celebrate outstanding contributions to global kidney care! Please join us in congratulating the winners of the 2026 ISN Awards:

Ya listos ✅ para mañana 📆, acompáñanos en el “Taller de Lesión Renal Aguda y Terapias Extracorpóreas” @SLANH_ 2025 XXI Congreso Latinoamericano de Nefrología e Hipertensión #SLANH2025 Guayaquil 🇪🇨

Buenos días 🌞 #KidneyRunners 🏃🏻‍♂️ #Run4Kidneys 🫘 #850Challenge 🎗️

#JustDoItSunday 🏃🏻‍♂️ #Run4Kidneys 🫘 #850Challenge 🎗️

Severe AKI linked to intestinal ostomies
In a 📑study, Ostomy-AKI was:
🔹 More often hypovolemic (49% vs 25%)
🔹 More severe (Stage 3: 83% vs 64%)
🔹 With higher mortality (60% vs 37%)

➡️ Highlights the need for close monitoring in ostomy patients.
#AKI doi.org/10.1016/j.xk...