📣 We’re hiring!
My team at Mass General Brigham / @broadinstitute.org is growing:
• Postdoc (PhD; human 🧬 & multi-omics)
• Research fellow (clinical trials & epi; 2-yr)
• Computational associate
Join a collaborative, high-impact 🫀 precision medicine team.
DM or email mhonigberg@mgb.org
A JAMA Cardiology article, published November 9, 2025, titled "Clonal Hematopoiesis—An Opportunity to Confront the Heart Failure Epidemic" by Domingo A. Pascual-Figal and José J. Fuster, discusses the relationship between CHIP and heart failure.
💬 Invited Commentary: Flynn et al find non-DNMT3A clonal hematopoiesis of indeterminate potential (CHIP) mutations most strongly associated with heart failure risk in UK Biobank data, supporting gene-specific risk assessment.
#AHA25 @ahascience.bsky.social
ja.ma/4p56SeB
JAMA Cardiology graph titled, "Clonal Hematopoiesis and Incident Heart Failure." It shows mediation analyses for clonal hematopoiesis of indeterminant potential(CHIP) and incident heart failure. Coronary artery disease, atrial fibrillation and combined model has highest %
Non-DNMT3A clonal hematopoiesis of indeterminate potential (CHIP) subtypes—including TET2, ASXL1, JAK2, and spliceosome genes—demonstrated higher association with incident heart failure compared to DNMT3A.
#AHA25 @ahascience.bsky.social
ja.ma/3JQSveI
November issue now live, with Reviews on:
-Clonal haematopoiesis in cardiovascular disease
-Regulators of cardiomyocyte proliferation
-Extracellular vesicles in cardiovascular homeostasis and disease
-Factor XI inhibitors for venous and arterial thromboembolism
www.nature.com/nrcardio/vol...
In this exploratory analysis, treatment with low-dose colchicine was associated with an attenuated annual clonal growth in TET2 CH. These findings suggest the potential for colchicine to curb the proliferative advantage of key CH driver mutations https://bit.ly/3HWJL5M
#ESCCongress #WCCardio #JACC
A graph titled Figure 1. Cumulative Incidence of Myocarditis and Pericarditis During Follow-Up by Clonal Hematopoiesis of Indeterminate Potential (CHIP) Status displays three lines: Large CHIP, Any CHIP, and No CHIP, charting cumulative incidence over follow-up time.
Among middle-aged adults, clonal hematopoiesis of indeterminate potential (CHIP) was linked to an increased risk of developing myocarditis and pericarditis.
#ESCCongress #WCCardio
ja.ma/45RBaJG
New report that CHIP (clonal hematopoiesis of indeterminate potential, blood stem cell clones that increase with age) is an independent risk factor for myocarditis and pericarditis, promoting inflammation #ESC2025
@jama.com
jamanetwork.com/journals/jam...
(6/X)
Our findings suggest CHIP remains relevant into later life & underscore its heterogeneity.
Paper (OA): www.jacc.org/doi/10.1016/...
Editorial: www.jacc.org/doi/10.1016/...
Come see @danielezzat.bsky.social 's presentation #ESC2025 (29 Aug 10:15a)!
@mghcvrc.bsky.social @broadinstitute.org
(5/X)
HRs for CHIP were comparable or greater than those for other conventional CVD risk factors (e.g., 👇)
In addition, we examined alternate thresholds of variant allele frequency to define CHIP; associations generally ⬇️ w/ smaller clone size
(4/X)
Key CHIP subtypes were associated w/ adverse CV events
Consistent w/ our prior work, TET2 CHIP associated w/ CHD & HFpEF
👀 ASXL1 CHIP ➡️ HFrEF (aHR >3)
Notably, no associations were seen when we lumped all CHIP types together, underscoring its heterogeneity
(3/X)
We therefore examined ~6,700 👵👵 from the Women's Health Initiative Long Life Study (median age 80 y) and sequenced blood cells ~4,500x in each participant to accurately detect 🔍 and quantify CHIP
Women were followed for ~10 y for coronary heart disease and several secondary outcomes
👇
(2/X)
CHIP = aging-related acquired blood stem cell mutations that predispose to blood cancers
We + others have shown that CHIP also associates w/ ⬆️ CVD risk
But previous work suggested attenuation of associated risk in older adults, who have highest risk of both CHIP + CVD
The lab's first sim pub of #ESC2025 is now online in
@jaccjournals.bsky.social #JACC!
jacc.org/doi/10.1016/...
Led by 🇧🇪⭐️ @danielezzat.bsky.social , we examined clonal hematopoiesis (CHIP) 🩸 & CV 🫀 outcomes in older women 👵 using deep targeted 🧬 sequencing in the WHI Long Life Study
👇
(1/X)
Fantastic joint lab retreat today w/ @pnatarajanmd.bsky.social @zhiyu.bsky.social & Akl Fahed labs
Honigberg lab is rapidly growing 📈 👇
@mghcvrc.bsky.social @mgbwomenheart.bsky.social @mgbresearch.bsky.social
Now accepting applications for the 2026-2027 Women's Heart Health Program Fellowship!🫀Click here for details: massgeneral.org/heart-center...
@mdharringtonc.bsky.social @emilyswlau.bsky.social @mchonig.bsky.social
Registration is now open!📣We're co-hosting a patient SCAD Symposium with @scadalliance.bsky.social in October 🫀
Please click on the event page to register & for all of the details! massgeneral.org/heart-center...
@emilyswlau.bsky.social @mdharringtonc.bsky.social @mchonig.bsky.social
The latest from our @americanheart.bsky.social -funded BUSY-BP study, led by MGH medicine resident Lulu Belak, now in Obstet Gynecol @greenjrnl.bsky.social
In Black + Latina 👭, burden of health-related social needs in pregnancy was associated w/ adverse 🤰 outcomes
journals.lww.com/greenjournal...
The inaugural MGB & Inova YIA was a huge success 🎉Please join us in congratulating 👏👏
Basic & Translational category:
Winner: Maria Pabon (BWH)
Honorable Mention: Amelie Vromman (BWH)
Clinical Research category:
Winner: Meesha Vullikanti (Yale)
Honorable Mention: Izza Shahid (Houston Methodist)
Huge congrats to @massgeneralbrigham.bsky.social MGH medicine resident Amanda Jowell for receiving a top resident abstract award for her analysis of female-specific CVD risk factors in severe hypercholesterolemia 🏆 @mgbwomenheart.bsky.social @mghcvrc.bsky.social
29.05.2025 14:10 — 👍 8 🔁 3 💬 0 📌 0
Big congrats to Maria Pabon for winning the inaugural @mgbwomenheart.bsky.social / @ishvnews.bsky.social Young Investigators' Award (basic/translational category) for her work on endothelial cell transcriptomics in preeclampsia (www.ahajournals.org/doi/10.1161/...)! 🏆 @cardioob.bsky.social
10.05.2025 17:38 — 👍 7 🔁 2 💬 0 📌 0
Genetic Risk & 1st-Trimester CV Health Predict Hypertensive Disorders of Pregnancy in Nulliparous Women
#CardioObstetrics #CardioSky #JACC
www.jacc.org/doi/10.1016/...
@mchonig.bsky.social @garimasharmamd.bsky.social @jaccjournals.bsky.social @csilvers.bsky.social @mdharringtonc.bsky.social
Our latest on 🫀 health, 🧬, and 🤰 now out in @jaccjournals.bsky.social #JACC
First-trimester cardiovascular health strongly associates with development of hypertensive disorders of 🤰 (HDP)
overall and across levels of HDP genetic risk
www.jacc.org/doi/10.1016/...
#CardioObstetrics #CardioSky
We love our team ❤️ Check out @mchonig.bsky.social's latest review!
02.04.2025 20:16 — 👍 3 🔁 2 💬 0 📌 0… posted prematurely/in error without acknowledging the awesome work of lead author and overall rockstar @artschuermans.bsky.social !
02.04.2025 18:30 — 👍 1 🔁 0 💬 0 📌 0
Check out our latest review on clonal hematopoiesis🩸🧬 and cardiovascular disease 💔 now out in @natrevcardiol.bsky.social
www.nature.com/articles/s41...
Full text link: rdcu.be/ef9VW
@mgbresearch.bsky.social @mgbwomenheart.bsky.social
@mgbwomenheart.bsky.social
02.04.2025 16:42 — 👍 1 🔁 0 💬 0 📌 0
Check out our latest episode of HeartBEATS from the @americanheart.bsky.social focused on peripartum cardiomyopathy 🤰🫀 #PPCM ! @cardioob.bsky.social
professional.heart.org/en/education...
Our team is gearing up for #ACC25! We'd love to see you! Come find us at one of our sessions! 🩺♥️
@mchonig.bsky.social @mdharringtonc.bsky.social @accintouch.bsky.social
