Synthesis Journal

Join Thieme #Cheminar dedicated to Prof. Erick Carreira 🤩 with our speakers Profs. Tobias Ritter (Germany), Song Lin @songlin1.bsky.social (USA) & Sarah Reisman @reiswoman.bsky.social (USA), chaired by Prof. Mark Lautens @marklautens.bsky.social

📅August 14, 2025 ⏰3 PM (GMT+2)

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Ever wondered how chemists build complex molecules? 🧪 A novel #DominoReaction by Chada Raji Reddy and co-workers now synthesizes 3-nitrocarbazoles by forming two new C-C bonds in one elegant sequence! Key for organic semiconductors and LEDs.
#carbazole

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Dive into copper-catalyzed enantioselective allylic/propargylic #acyloxylation 🌟 Our review by Tang & Yu highlights this powerful strategy, evolving from the #Kharasch–Sosnovsky reaction, for synthesizing chiral esters!
#catalysis #copper

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Ever wondered about the magic behind #GrubbsHoveyda Catalysts? Jun Okuda & co-workers are making strides in ring-closing #metathesis in water! Discover how swapping halides changes everything – from activity to robustness✨
#catalysis

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Dive into N-heterocyclic carbene #borane Type I photoinitiators! Lalevée, Lacôte & co-workers achieved the first homolytic B–N bond #cleavage, enabling new PIs with rapid #photolysis and outstanding #polymerization. A breakthrough for high-performance applications🤯

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Dive into the fascinating world of #organoboron compounds! 🧪 This review by Xie & Xuan explores #photocatalytic boryl #radical reactions with NHC-BH₃, revolutionizing C–B & X–B bond formation. Discover the progress and challenges!

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Check out this efficient & environmentally friendly protocol by Yan, Cao & co-workers for synthesizing 1-(α-hydroxyindole)-o-carboranes✨ It's a #Friedel-Crafts reaction of #indoles with 1-formyl-o-carborane, no solvent or #Lewis acid needed🌱

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Got any interesting chemistry news today? Chen, Yang & co-workers have developed a new synthesis for a chiral #difluoropiperidine intermediate! This breakthrough uses SF₄–HF and smart early-stage resolution. Next stop: scaling up with flow chemistry🚀

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Constanze Neumann and co-workers developed an efficient, transition-metal-free method for 1,3-diols using a "traceless" directing group and a MOF #rhodium catalyst🧪 This three-step process delivers remarkable selectivity.
#catalysis

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A fantastic new study from Yi, Huang, and co-workers! They've developed two unprecedented #cascade reactions to create chiral tetrahydrofurans with excellent enantioselectivities up to 98% ee, all using a single phosphoric acid catalyst🧪
#catalysis

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The new study of Vlad Iluc & co-workers shows how #iron complexes with pincer ligands can facilitate unique C(sp²)–C(sp²) coupling! This work observed fascinating oxidative coupling with alkynes, leading to η⁴-butadienes🧪
#catalysis

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Uncover the selectivity!✨ Zanatta & co-workers are presenting a direct N-alkylation/arylation methodology for #imidazoles, #pyrazoles, and #triazoles. Their work, featuring brominated enones, creates N-alkylated #azoles with furans or dihydrofurans.

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Are you advancing the science of Synthetic #Chemistry? SYNTHESIS is the home for your research.

Why publish with SYNTHESIS?

🌟 Established Reputation
📈 High Readership
🥇 Annual Best Paper Award
...and more!

Have your work seen by a global audience.
Submit today: buff.ly/BZkKnCO

Dive into the fascinating world of environmentally friendly chemistry! 🌿 Discover the latest development in reducing nitro compounds to amino compounds using ball-milling by Lu & co-workers!
#ballmilling #chitosan

Read more👉 buff.ly/W80mx0q

From precursor to powerful compounds!🧪 Kwesiga, Schmidt & co-workers achieved the total synthesis of three unique prenylated #isoflavones. This breakthrough enables comprehensive antimicrobial profiling! Stay tuned for results. #NaturalProducts

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Our paper on the synthesis of >50 iodine reagents, and the systematic analysis of their electrochemical properties, is just out in Synthesis @synthesis1969.bsky.social 🤩

⚠️Full disclosure: this is my very first paper without transition metals! 😜 read it here: www.thieme-connect.com/products/ejo...

oin us for a Thieme #Cheminar on Thieme Chemistry Awardees🏆with Stephen Fielden @stephenfielden.bsky.social (University of Birmingham), Adam Noble (University of Bristol), Allegra Franchino (Durham University)

📅 July 17, 2025 ⏰ 10 AM (CEST)

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Stavagna & Buettner's  photocatalytic #borylation of α-(trifluoromethyl)styrenes yields versatile difluoroalkene-aminoboranes 🧪 They're key synthetic building blocks enabling efficient #Suzuki-Miyaura cross-coupling and more!
#Photocatalysis

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New research alert🚨 Du, Lu, Chong & Meng developed a simple & efficient Co-catalyzed #hydroformylation of allyl alcohol esters. This method offers high reactivity, versatility, & exclusive chemo/regioselectivity for preparing aldehydes✨
#cobalt

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Explore #OlefinMetathesis! New research by Rouen, Mauduit & co-workers showcases photochemical activation of Ru-indenylidene catalysts for RCM, CM, & ROCM – achieving lower loading & faster reactions 🚀
#ruthenium

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Dr. Illia Sharanov from Thieme Chemistry is attending XL BRSEQ 2025 Conference in Bilbao with a great 1200+ audience. Fantastic to hear talks by Martin Oestreich (Synthesis EB), Ruben Martin (Synlett EB), and many others.

Thanks to the organizers and participants for an inspiring event! #BRSEQ2025

Dive into chiral #DrugDevelopment 💊 This review by Álvarez-Calero & Horwitz @synthesisworkshop.bsky.social highlights efficient, scalable #API synthesis for new drug substances. Discover how asymmetric synthesis drives #pharma innovation via diverse case studies 🧬

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Thieme Table at European Conference of Organic Synthesis

Hello from the #ESOC2025 in sunny Copenhagen!
You are welcome to visit us at our table #Thieme to learn more about our journals and databases. @synthesis1969.bsky.social @synlettjournal.bsky.social @synopenjournal.bsky.social @suscircnow.bsky.social #ScienceofSynthesis

Ni-catalyzed C–H functionalization just got easier 🎉 M. Kundu, T. Kundu & co-workers report a scalable ortho-C(sp²)–H arylation/alkylation protocol using 8-AIP as an inbuilt directing group! Great for late-stage functionalization & making diverse amides.
#nickel

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Explore the world of alkenes!🚀 This review by Yang, Ge and co-workers highlights recent advancements in transition-metal-catalyzed remote 1,n-difunctionalization✨ Discover how chain-walking processes build complex organic frameworks.
#catalysis

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Dive into the green synthesis of vital heterocyclic systems using #graphitic carbon nitrides🧪 A review by Ankita Rai & co-workers highlights how these polymers are transforming heterogeneous and photocatalysis, with huge implications for medicine💊

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From lab to life: #Spirocyclopropanes are key in natural products & drugs💊 This review (1989-2024) by Hitendra Patel and co-workers showcases synthetic routes, including organocatalysis & precursors. The next frontier? Regio/stereoselective control!

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Allylic alcohols are key in organic synthesis🧪 A new review by Yang & Fang sheds light on their conversion to saturated alcohols using tandem isomerization/(transfer) #hydrogenation with #ruthenium catalysts🔥

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Dive into #ferrocene and explore the latest in its C–H functionalization and side-chain modifications! The review by Jung Min Joo and co-workers highlights strategies to fine-tune its properties for applications like energy storage and sensors

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Reminder: Don't miss our #Cheminar tomorrow at 10 AM (CEST)!👇