Synthesis Journal

💡Visible-light C(sp³)–H oxidation of 8-alkylquinolines by Punniyamurthy & co-workers using [Mes-Acr-Me]BF₄ under air delivers C8-carbonyl quinolines (aldehydes, ketones & esters) ✨
#photocatalysis

👉 buff.ly/VquYCQr

Mario Ordoñez & co-workers report a regioselective phospha-Michael addition on chromone, followed by NaBH₄ reduction to access novel cis/trans 4-hydroxychroman-2-yl phosphonate derivatives ⚗️✨ Great potential for further synthetic exploration!

👉 buff.ly/lT5ppU7

Dive into the evolving chemistry of #catechols 🔬 Discover how catalyst-controlled regioselectivity is opening new paths to multisubstituted derivatives✨ In this review, Sohtome & Kihara explore recent advances, challenges & mechanistic insights.

👉 buff.ly/LqTns3O

Join Thieme #Cheminar “Small Molecules in Medicinal Chemistry”🔬 with our speakers Prof. Arlene Gonçalves Corrêa (Brazil) & Prof. Kelvin Billingsley (USA), hosted by Prof. Debabrata Maiti and brought to you by @synlettjournal.bsky.social

📅December 10, 2025 ⏰5 PM (GMT+1)

👉 buff.ly/KhmBHll

Seven new P(V)-stereogenic #organocatalysts synthesized! 🔬
Mathias Christmann ( @christmann.bsky.social ) & co-workers explore #squaramide & #thiourea linkers in asymmetric transfer hydrogenation & Mukaiyama–Mannich reactions — showing promising first results✨
#phosphorus

👉 buff.ly/zSmzJqJ

Dive into the vibrant chemistry of #nitroarenes 💥 Saroj Ranjan De & co-workers highlight recent advances in regiospecific ortho-nitration of protected anilines, a cleaner, smarter route to key intermediates for dyes, drugs & materials⚗️
#anilines #CHActivation

👉 buff.ly/GeQ4lqI

🔬 Explore the cutting-edge of #bismuth #photocatalysis💡Byeongdo Roh & Josep Cornella @cornellab.bsky.social unveil a groundbreaking method for amide desaturation to form enamides, redefining what main-group catalysis can do✨

👉 buff.ly/PSyA18N

#Sulfur is shaping the future of #DrugDiscovery! Wonchul Lee & co-workers review cutting-edge total syntheses of sulfur-rich natural products (2020–2024), from #thioethers to #thiazoles 🧪

👉 buff.ly/CybW19K

Yanhua Zhang & co-workers showcase a green, efficient electrochemical method to turn aryl alkynes + CO₂ into acrylic & propionic acids! Using an Al/Pt/Ag–AgBr setup in TBAB/MeCN, yields reach 72% and product selectivity is tunable over time⚡️
#electrochemistry

👉 buff.ly/sNCqP8K

Explore the dynamic world of #spiropyrans & #merocyanines ! Discover how electron-donating and -withdrawing groups shape photochromic behavior using UV/Vis, NMR & DFT insights by Ralf Wolfgang Giernoth & co-workers📊
#photochromism

👉 buff.ly/65euLti

Transition metal-free #CrossCoupling 🚀 Alkyl fluorides + #Organolithiums react under mild heat with liquid-assisted stirring w/o expensive catalysts🔥 Tolerates 3° fluorides & diverse functional groups🧪 This breakthrough by Wolf & co-workers could reshape TM-free coupling chemistry

👉 buff.ly/tWFwGiw

From Si & Ge to Sn⚗️This review by Guillaume Lefèvre & co-workers explores #bis-alkenyl group XIV compounds – their formation from halide precursors, versatile functionalizations & roles in polymers, materials & fine chemicals🌟

👉 buff.ly/pqrRST0

Metal-free & radical💥A #xanthate -mediated cascade builds #spiroindolines via addition, spirocyclization & oxidation🌀 Broad scope (esters, nitriles, ketones, lactones) & up to 99% yield ⚗️Unlocking bioactive scaffolds by Luis D. Miranda & co-workers✨

👉 buff.ly/2pAJOcC

Yongseok Kwon & co-workers review a decade of enantioselective C–C bond formation via redox-active esters + #photoredox & CPA catalysis💡 From Minisci α-amino radicals to Friedel–Crafts acylimines, dual activation is opening new stereochemical frontiers⚡

👉 buff.ly/a1JV95z

Turning amides into amines & nitriles with light!💡Using Fe₂(CO)₉ under blue LED irradiation, Christophe Darcel & co-workers showcase a selective, mild #desulfurization via hydrosilylation, a sustainable twist on iron #catalysis

👉 buff.ly/UtXQrvR

Explore the #gold standard in #catalysis! Dive into our review by Long Li  & co-workers on gold-catalyzed asymmetric #alkyne transformations, from ligand engineering to central-to-axial conversions. Discover new paths in #chirality & sustainable synthesis✨

👉 buff.ly/z0wMqw9

#Organosodium reagents are emerging as greener, more reactive alternatives to lithium🧪 Benzyl sodium shows divergent reactivity with #pyridines, unlocking access to #dihydropyridines 🔍 New mechanistic insights revealed by Eva Hevia & co-workers @evaheviagroup.bsky.social

👉 buff.ly/DThXVcG

🚀 Countdown to SCNOW Virtual Summit, 6–7 Nov! 🌱♻️

Join top experts in sustainable & circular chemistry from #academia, #industry & #policy. Connect, exchange ideas & drive impact.

💻 Register NOW: cassyni.com/s/scnow-virt...

#SCNOWVirtualSummit #SCNOWPosterSession #Sustainability

🔎 Isocyanoalkenes, an underexplored class of #isocyanides , are unlocking new paths in heterocycle synthesis🌱From biosynthesis to reactivity (conjugate & radical additions), this review by Huan Tian & Fraser Fleming highlights their vast synthetic potential🧪

👉 buff.ly/tJWJ5Z4

Discover how chiral Pd complexes enable enantioselective #SuzukiMiyaura reactions with chain-walking🚀 A new path to pharmaceutically relevant, enantiomerically enriched targets by James Morken & co-workers✨
#organoboron #catalysis

👉 buff.ly/6YZ2sko

#Morpholine amides take the spotlight🌟 Yohei Ogiwara reviews their unique reactivity & chemoselectivity in ketone, aldehyde & acylsilane synthesis🧪 Applications include natural product synthesis, Vilsmeier–Haack reactions & polymer recycling!

#OpenAccess 👉 buff.ly/34Wm4nT

William Erb & co-workers show how #hexafluoroisopropanol (HFIP) promotes pseudo-benzylic substitutions, enabling access to bulky diphosphine ligands & phosphonates🧪 Key tools for metal complexes & #phosphine synthesis🌟
#ferrocene

👉 buff.ly/8QjPcGl

A fresh look at #gold & #platinum catalysis! ✨ Véronique Michelet @vmichelet06.bsky.social & co-workers review [2+2+2] Prins-type #cyclizations with alkynes/allenes, alkenes & carbonyls🔬 Covers intra/intermolecular strategies & enantioselective applications 🌟

👉 buff.ly/roTiTeW

Rapid access to 1,2- #diazepines from #pyridines via ylide formation under 370 nm light, as reported in the paper of Tomislav Rovis & coworkers🚀 Tuning the protecting group enables diverse substrates, offering a one-pot route to rare drug-like cores💊

👉 buff.ly/UXBkq9a

⚡Charge-enhanced H-bond & #Brønsted acid catalysis is redefining synthetic chemistry! Boosting rates & selectivity, these systems, like #amidinium & cationic phosphoric acids, bring enzyme-like efficiency, as highlighted in our review by Travis Dudding & co-workers🚀

👉 buff.ly/yidWGLw

Ni-catalyzed selective monodefluorinative alkylcarbonylation of α-CF₃ styrenes with alkylzinc pivalates under 1 atm CO gas by Jie Li & co-workers🚀 Mild conditions and broad substrate scope make this method highly versatile⚡
#monodefluorination #nickel #catalysis

👉 buff.ly/3EtnXgO

Exploring #enyne metathesis in green solvents, supercritical fluids & under microwave tech🌱 From cross- to ring-closing pathways, #ruthenium catalysts & tandem strategies, discover it all in this review by Mao, Melot @rmelot.bsky.social & Michelet @vmichelet06.bsky.social 🚀

👉 buff.ly/XNGUsN9

Harnessing sunlight for C–C bond formation☀️ Dimethyl-aniline–alkyl halide charge transfer complexes enable reactions with #malonates , #malononitriles & 2-cyano-esters 🔬✨ DFT unveils the mechanism in this study by Alex Szpilman @amszpilman.bsky.social & co-workers
#photochemistry

👉 buff.ly/XNGUsN9

Join Thieme #Cheminar “Boron in Organic Synthesis”🔬 with our speakers Profs. Varinder Aggarwal (UK), Andrei Yudin (Canada) & Benjamin Stokes (USA), hosted by Prof. Thierry Ollevier and brought to you by @synopenjournal.bsky.social

📅October 16, 2025 ⏰3 PM (GMT+2)

👉 buff.ly/v41RiQI

From Ziegler’s legacy to today’s 🚀 #Organoaluminum chemistry is evolving: hydro-/ #carbometallation, terminal #alumination & C–H activation open new paths! Dive into the review by Piccardi & Micouin @lmicouin.bsky.social ✨

👉 buff.ly/XNGUsN9