Synthesis Journal

🔬 Check out the 2025 #NobelPrize in Chemistry!

This year’s award goes to Susumu Kitagawa, Richard Robson, and Omar M. Yaghi for their pioneering work on metal–organic frameworks (#MOFs), highly porous materials that can capture CO₂, store gases, and even pull water from the air!

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Versatile 1,2-oxazin-4-ones pave the way to enantiopure amino #polyols 🧩 Reissig, Zimmer & co-workers show syn/anti selectivity in #Grignard & #enolate additions, δ-lactone & bicyclic polyol formation, plus Pd & SmI₂ reductions⚡

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🚀 Explore cutting-edge strategies for turning propargyl alcohols into #allenes ✨ A short review by Amgoune & co-workers (ICBMS) highlights how transition-metal #photoredox catalysisdrive these advances through oxidative addition & photoinduced C–O cleavage⚡

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☀️Anthore-Dalion @lanthoredalion.bsky.social & co-workers report a Re(I) photocatalyst enabling ultra-fast (<5 min) #deoxygenation of N-heterocyclic & alkyl N-oxides💡Air-tolerant, scalable, and highly functional group-friendly⚡️
#rhenium #photocatalysis

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🚀Acuña-Bolomey & Oestreich @silicon-martin.bsky.social reveal an enantioconvergent Ni-catalyzed C(sp³)–C(sp³) coupling, unlocking α-chiral #alkylgermanes🧪 Novel PyBox ligands tackle selectivity challenges & pave the way for next-gen #organogermanium chemistry✨
#nickel

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✨From Special Topic Romanian Chemists in Synthesis✨

One-step breakthrough⚡️A new catalytic system enables efficient synthesis of 5,5′-bi-triazole bis-macrocycles🧪Born from a serendipitous by-product➡️now optimized for selectivity & yield✨
#CuAAC #triazoles #macrocycles

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✨From Special Topic Romanian Chemists in Synthesis✨

🚀π-Coordination is unlocking new ways for C–H & C–O activation! This review by Mutoh & Ilies highlights Pd–arene–Cr complexes and future transient strategies for sustainable synthesis🧪
#catalysis

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⚗️First-of-its-kind Co-catalyzed cross-coupling! Gosmini & co-workers report that benzyl sulfonium salts, readily made from alcohols, react with aryl bromides to give a wide variety of #diarylmethanes in good to excellent yields✨
#cobalt #catalysis

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Why is #fluorine the ultimate game-changer in organic chemistry?💡In their latest review, Zhan-Yong Wang & co-workers cover a decade of #monofluorination breakthroughs – from radical routes to #Selectfluor magic – showing how chemists craft C–F bonds with precision.

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💡Yadav & co-workers developed a divergent DABCO-catalyzed route to allyl #sulfones via α- and γ-substitution of Morita–Baylis–Hillman acetates with #sulfinates, delivering alkyl 2-(phenyl(tosyl)methyl)acrylate derivatives in high yields with excellent stereoselectivity

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💻 AI is changing research - and peer review is no exception.

At Synthesis Journal, we mark #PeerReviewWeek2025 by reflecting on both the opportunities (efficiency, support, integrity) and the challenges (bias, transparency, safeguards) that AI brings to peer review.

#AI #PeerReview #Thieme

Our review by Anju Nalikezhathu & Travis Williams explores hydrogen borrowing #catalysis, an atom-economical, cost-effective route where alcohols alkylate amines with only water as by-product💧Explore catalysts, pharma uses & green, low-PMI processes🔬

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In this work by Joyce Grimm & Nobel Laureate Benjamin List, the intramolecular #Prins reaction of O-prenylated #salicylaldehydes delivers 4-chromanols with outstanding efficiency & selectivity using a fluorinated iIDP #Brønsted acid catalyst⚗️
#organocatalysis

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Dive into the world of substituted alkynes🚀 From #diynes to #enynes, our review by Janine Cossy explores the latest in chemo- & stereoselective C–C bond formation via alkynyl #CrossCoupling, powered by affordable Mn, Fe, Co, Ni & Cu catalysts🔬
#catalysis

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Highlights from #OMCOS22 in Kyoto 🌸

Prof. Martin Oestreich gave a great talk titled ‘The Cation Shuttle‘ & handed the certificate for the ‘Lives in Chemistry’ project to Nobel Laureate Prof. Ryoji Noyori.

Many thanks to Prof. Hideki Yorimitsu & Prof. Michinori Suginome for a fantastic event!

Small-molecule #alcohols go beyond solvents⚡️A new review by Dayun Huang & co-workers explores their role as green, versatile reactants in organic #electrochemical synthesis, covering etherification, esterification & alkylation 🍃

Read more👉 buff.ly/KVuWmCm

H. Gong & co-workers report a Ni-catalyzed cross-#hydrodimerization of enamides & unactivated alkenes, delivering α-branched amines/secondary amides via C(sp³)–C(sp³) bond formation with high regio- & enantioselectivity🌟
#catalysis #BiOx

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Once overlooked, the Cargill-type rearrangement is making a comeback. Strain-driven [1,2]-shifts are unlocking new paths in #SkeletalEditing - a focused review by Bo Xu & co-workers explores its mechanism⚙️, scope, and strategic potential in #TotalSynthesis

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✨From Special Topic Romanian Chemists in Synthesis✨

Andruh, Nica & co-workers report a [2+3] hexaimine cage from #azulene units with symmetric π-stacking, visible absorption & #fluorescence. Reduction to a hexaamine cage alters stability & redox properties💡

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✨From Special Topic Romanian Chemists in Synthesis✨

Explore redox-switchable #polymerization! See how #counteranion choice tunes rates and monomer selectivity for diblock copolymer design in the letter by Diaconescu & co-workers⚡
#electrochemistry

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🚨Special Issue Alert!
Discover our latest research in SYNLETT celebrating the achievements of Romanian Chemists in #synthesis 🇷🇴 Innovative chemistry from talented researchers!🔬

🔜 This week we’ll spotlight all papers from this special topic. Stay tuned!

Read it here👉 buff.ly/hQNM3Sz

Very excited to announce that our recent review has been featured on the cover of Synthesis!!

If you haven't had a chance to check it out yet, here is a link to the review: doi.org/10.1055/a-26...

✨Bürgenstock Special Section 2023✨

Electrochemical α-functionalization of #ketones by Vantourout, Echeverria, Gnaim & co-workers⚡#Umpolung reactivity enables C–C, C–Cl, and [3+2] #cyclizations in an undivided cell, air/water tolerant!
#electrosynthesis

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✨Bürgenstock Special Section 2023✨

Catalyst-free #photochemistry by Line Næsborg & co-workers!🌱 Protonation of (E)-anethole in HFIP leads to a photoactive EDA complex that drives radical chain cyclizations under green light #irradiation 💡

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✨Bürgenstock Special Section 2023✨

#Electrochemical insights⚡ Alicia Casitas @aliciacasitas.bsky.social & co-workers report reduction potentials for 50 iodine(III) reagents, including cyclic alkynyl, vinyl, aryl, CN, CF₃, and iodonium salts, measured by CV

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✨Bürgenstock Special Section 2023✨

First enantioselective #TotalSynthesis of lucidumone in 13 steps🍄! Aurélien de la Torre @auredelatorre.bsky.social & co-workers use a retro-[4+2]/#DielsAlder cascade to access this COX-2 selective #meroterpenoid

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✨Bürgenstock Special Section 2023✨

Christopher Teskey & co-workers highlight how simple ligand #photodissociation in #cobalt #catalysis enables light-controlled reactivity switches🔦, offering access to distinct outcomes.
#photochemistry

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🚨Special Issue Alert❗
Check out our latest SYNTHESIS Special Issue dedicated to the Bürgenstock Conference 2023! Cutting-edge research in organic chemistry from future stars in #OrganicChemistry ⭐

🔜 Next week we’ll spotlight all papers from this section. Stay tuned!

Find more here👉 buff.ly/oPR0PfM

Fast, visible-light thiol-ene coupling in just minutes💡 Using N-enoxybenzotriazoles under on-water conditions🌊, this radical chain reaction by Seunghoon Shin & co-workers shows exceptional speed, yield & robustness across diverse environments💥
#photochemistry

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💥Enantioselective alkylation of metal #enolates is unlocking new frontiers in α-chiral carbonyl synthesis! This review by Li and Yin covers both stoichiometric & catalytic strategies, recent scope expansions, and the challenges ahead—like secondary alkylation & γ-selectivity.

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