Mike Inouye

A line graph showing NSF grant awards made through 2/27/26 for fiscal year 2026 compared with grant awards for fiscal years 2021-2025.

NSF Update (Awards through 2/27/26)

Directorates to follow

1/10

Happy to share new manuscript I completed with @ee-reh-neh.bsky.social & @davisjmcc.bsky.social back in Melbourne. The work originally conceived by @ijbeasley.bsky.social focuses on how we can reconcile and meta-analyse eQTL studies across studies cohorts and ancestries. doi.org/10.64898/202...

Power is a major confounder in the analysis of cross-ancestry 'portability' in human eQTLs https://www.biorxiv.org/content/10.64898/2026.02.26.708346v1

Finally, today's offering! www.biorxiv.org/content/10.6...

This began life as a very different project which failed because we couldn't agree on defining eqtl sharing across cohorts. So two young members of the lab dug deeply into this - first @ijbeasley.bsky.social, then @patrickgibbs.bsky.social

‘Unbelievably dangerous’: experts sound alarm after ChatGPT Health fails to recognise medical emergencies Study finds ChatGPT Health did not recommend a hospital visit when medically necessary in more than half of cases

Study finds ChatGPT Health did not recommend a hospital visit when medically necessary in more than half of cases. www.theguardian.com/technology/2...

The impact is already hitting science agencies hard. The NIH—the world's largest public biomedical research funder—has had to rely on leftover stopgap funds.

New grant awards have slowed to a trickle — exacerbating the effects of a record-long shutdown in October.

(h/t @jeremymberg.bsky.social)

White House stalls release of approved US science budgets The US Congress rejected sweeping cuts to science agencies. But the NIH, the NSF and NASA have had their spending slowed.

Congress rejected massive cuts to US science budgets for 2026, but much of the money still isn’t flowing to researchers.

The culprit? The White House Office of Management and Budget (OMB) is quietly slow-walking the release of funds. 🧵👇

Polygenic risk scores explained Research powered by UK Biobank’s genetic data is revealing polygenic risk score promise for personalised healthcare - and their limitations.

An explainer on polygenic risk scores from UK Biobank @ukbiobank.bsky.social www.ukbiobank.ac.uk/research-sto...

I remember when these were so rudimentary we were still arguing over what to call PRS.

Now, apparently BUPA are amongst those offering PRS! healthcareandprotection.com/bupa-launche...

Joy of joy!

In a collaborative office, engineers deploy AI intelligence.

Using clinical prediction models to predict illness and make decisions can lead to a worsening in existing inequities. Using ‘subgroup net benefit’ looks beyond the algorithms to add clinical & social context.

Full paper: ths.im/3MtKwFL
THIS summary: ths.im/4tV65zY

I understand why chatbot cheating happens but every time I read about it I want to gently remind everyone that the point of schoolwork is not for the submission to exist. Teachers are not just greedy for more essays or solved equations. The point is to do the work WITH YOUR OWN BRAIN, FOR LEARNING.

University of Cambridge to keep vet school open The university's general board agrees a new way forward for veterinary education.

University of Cambridge to keep vet school open
www.bbc.co.uk/news/article...

General board: "Biological Sciences cannot be solely responsible for the future of veterinary education"...
will look to "develop and evaluate alternative models for the future of veterinary education at Cambridge" 👏👏👏

When will FT learn that John Burn-Murdoch should be doing all their content?

‘Don’t go to the US – not with Trump in charge’: the UK tourist with a valid visa detained by ICE for six weeks Karen Newton was in America on the trip of a lifetime when she was shackled, transported and held for weeks on end. With tourism to the US under increasing strain, she says, ‘If it can happen to me, i...

A retired British primary school administrator with a British passport and a valid visa was shackled, chained and detained for six weeks by ICE

www.theguardian.com/us-news/2026...

Today is the National Day of Remembrance for US Executive Order 9066.

EO9066 illegally confiscated the property and possessions of all Japanese Americans, including my grandparents and other US citizens. It forced them into remote concentration camps for years.

I'm now making a list of companies that I didn't receive the same level of service from

Executive Order 9066 - Wikipedia

The American concentration camps continued throughout WW2… the racism and multi-generational destitution and trauma caused by this Executive Order is still prescient today. en.wikipedia.org/wiki/Executi...

Today is the National Day of Remembrance for US Executive Order 9066.

EO9066 illegally confiscated the property and possessions of all Japanese Americans, including my grandparents and other US citizens. It forced them into remote concentration camps for years.

Over the course of 2025, UKB researchers were forced to move all of their data analysis to the cloud rather than working with local copies. What was the effect of this move on scientific output? Here is a simple first pass at answering that question.

Do you want to pursue your ideas in computational biology independently, running your group in @embl.org‘s uniquely collaborative environment, beside world’s most comprehensive biomolecular data resources @ebi.embl.org in Genome Campus next to @sangerinstitute.bsky.social?
Apply to join us & share 🙏

Development of a Patient-Level Multi-objective Optimisation Model for Screening Strategies for Childhood Type 1 Diabetes - PharmacoEconomics Objective To develop a patient-level simulation model of type 1 diabetes (T1D) covering both childhood and adulthood. The goal is to identify and evaluate the cost-effectiveness of optimal screening f...

Our new microsimulation model to optimise T1D screening by balancing cost, pragmatism, and reduced diabetic ketoacidosis is out. #T1D #T1Dscreening doi.org/10.1007/s402...

The little fish that could. Today sees the publication of a long awaited paper from my group. This has been.

Super cool work on medaka by @ewanbirney.bsky.social and colleagues www.cell.com/cell-genomic...

Includes an excellent summary from Ewan via linkedin... and I maintain that 'humans aren't special' 😊 www.linkedin.com/pulse/little...

New study combines MPRAs+RNAseq to functionally validate 94 rare nc variants from blood trait GWAS -> identification of 22 w/ direct regulatory effects. Great example of what can be done from association work to functional validation!
🔗 www.cell.com/cell-reports...
(ft @mikeinouye.bsky.social et al)

A large language model for complex cardiology care www.nature.com/articles/s41...

I grew up watching Dave Krieg, Steve Largent, Curt Warner and Eugene Robinson… 12th man from the UK - Go Seahawks!!! 🏈🏈🏈

Why walking in a national park in the dark prompts people to turn off lights at home The starry skies we can see from the UK are being limited all the time by the glare of light pollution.

The starry skies we can see from the UK are being limited all the time by the glare of light pollution.

"The United Kingdom’s researchers are an under-used asset “that we need to sweat” to boost economic growth"

UKRI is "under-exploited"

The UKRI CEO in his own words.

Personal commentary: This isn't a comms issue. This is the UK's premier funding body failing to fulfil it's most basic functions.

"For BBSRC, where the council is moving to having calls that are always open, he said the opportunities will re-start “in a matter of weeks”. On MRC, he said he expects the pause “to run to early summer”

"MRC board chairs have been told to recommend no more than three grants each for funding this year, which is likely to see success rates plummet."