Mike Inouye

ICYMI it's not a Max Planck directorship but still a great opportunity to join an exciting research environment down under 😁 bsky.app/profile/mike...

Feel free to get in touch with me here (www.inouyelab.org/home/people) and also read about the research partnership between the Baker Institute and Cambridge Uni we'd hope you'd join

ICYMI it's not a Max Planck directorship but still a great opportunity to join an exciting research environment down under 😁 bsky.app/profile/mike...

Open Call for Expressions of Interest in Max Planck Directorships: Expressions of interest can be submitted until 31 October 2025.

Director at Max Planck - a unique position! The Open Call for Expressions of Interest in Max Planck Directorships is open now and can be submitted by the 31st of October 2025. ➡️ mpg.de/directors - Please share the Open Call among potential candidates.

Thread of bioinformatics rock stars.

1) Dexter Holland

Ricardo Severe

6) You know, I think creating biorxiv counts as bioinformatics.

ricardosevere.wordpress.com

The proportion of epistatic heritability that is estimated as additive by quantitative genetic models. Epistasis deviates more from additivity for lower frequency causal alleles, but on average >80% of biological GxG will just look like statistical G.

👍 Yep! And without experimental truth for GxG we're at the mercy of Occam's razor

At 17, Hannah Cairo Solved a Major Math Mystery | Quanta Magazine After finding the homeschooling life confining, the teen petitioned her way into a graduate class at Berkeley, where she ended up disproving a 40-year-old conjecture.

Delightful story about a 17-year-old homeschooler who disproved the 40-year-old Mizohata-Takeuchi conjecture. She decided to apply straight to graduate school, skipping the rest of high school and college. When she finishes, a PhD will be her first degree.

Text from an FAQ in Okbay et al 20222: https://www.nature.com/articles/s41588-022-01016-z a similar same statement is made in an FAQ in 2025: https://www.biorxiv.org/content/10.1101/2025.05.14.653986v1.supplementary-material Text reads: "The results of SSGAC studies have sometimes been used by online platforms, including some companies, to predict individual outcomes. We recognize that returning individual genomic “results” can be a fun way to engage people in research and other projects and to feed or stoke their interest in genomics. But it is important that participants/users understand that these individual results are not meaningful predictions and should be regarded essentially as entertainment. Failure to make this point clear risks sowing confusion and undermining trust in genetics research"

It is depressing, but all too predictable, how swiftly we’ve gone from the Social Science Genetic Association Consortium offering reassurances about the uses of behavioural polygenic scores to one of their lead authors marketing embryo selection for IQ

Oof

Woah. How many published R analyses using 0.4's one has to wonder...

Under which circumstances do genomic neural networks learn motifs and their interactions? The use of neural networks to model genomic data in sequence-to-function scenarios has soared over the last decade. There remains much debate about whether these models are interpretable, either inher...

Under which circumstances do genomic neural networks learn motifs and their interactions?https://www.biorxiv.org/content/10.1101/2025.07.25.666754v1

Wtaf

Development and recalibration of a multivariable type 1 diabetes prediction model for type 1 diabetes across multiple screening studies - BMC Medicine Background Accurate type 1 diabetes prediction is important to facilitate screening for pre-clinical type 1 diabetes to enable potential early disease-modifying interventions and to reduce the risk of...

🚨Big news! Excited to share my first PhD paper!🎉
We validated & improved a T1D risk model using TrialNet data (originally from TEDDY), boosting accuracy 📈
bmcmedicine.biomedcentral.com/articles/10....
Try the web tool 👉 t1dpredictor.diabetesgenes.org
#T1D #RiskPrediction #PrecisionMedicine #TrialNet

Image of an old building in Oxford with the heading 'postdoc opportunities' and the text 'computational approaches to improve rare disease diagnosis and treatment' and 'Big Data Institute, University of Oxford'

📣 We are recruiting! Please share!!

Are you a bioinformatician / computational scientist who wants to apply your skills to understanding regulatory biology and improving rare disease diagnosis and treatment? 🧠 💻 🧬 🩺

We have two roles available 👇

🧵 1/4

Exciting news from the Cambridge spinout and startup scene 🚀

Cambridge Innovation Capital (CIC) have announced that they are committing at least £100 million from their new fund to invest in University of Cambridge spinouts.

Tap to find out what they plan to do: bit.ly/4l3ZiOD

A more multi-polar scientific community wouldnt be a bad thing imho.

"Science might further decentralize into a multipolar order like the one that held during the 19th century, when the British, French, and Germans vied for technical supremacy."

Sad but all is not lost.

"... science itself, in the global sense, will be fine. The deep human curiosities that drive it do not belong to any nation-state..." www.theatlantic.com/science/arch...

This is true and it's a shame computational biology is marginalised in this way. At the same time, comp bio needs ways to test the new hypotheses it generates. How to do this rigorously without new data is challenging but not undoable. Panels also need to accept the hypotheses are empirical & TBD.

Group leader positions in @sangerinstitute.bsky.social Cellular Genomics, led by @mhaniffa.bsky.social, to decode and recode human tissues. Broad net - clinical research, in vitro models, single cell, AI. Vibrant, supportive community. Please share!

sanger.wd103.myworkdayjobs.com/en-GB/Wellco...

Pleased to say that our preprint benchmarking Nanopore data for MLST, cgMLST, cgSNP & AMR typing from bacterial isolates is out! TL;DR you can get almost perfect results from 50x depth using live SUP basecalling with a GPU in under 20 hours #microsky#IDsky 🦠🧬🖥️ /1
www.medrxiv.org/content/10.1...

part 3

Seafood paradise, part 2

📣📣 Cool job alert! The @bakerresearchau.bsky.social is recruiting up to 2 new PIs in Biomedical Data Science 👉 www.seek.com.au/job/85989791...

You’d join an awesome institute in an incredible city (Melbourne, Australia) as well as partnerships like with @cam.ac.uk… you’ll also get to work with me 😁

I honestly hardly recognise the US anymore. The last 25 years have not been kind.

How China’s bold talent recruitment has shaped science Many Chinese researchers have received enviable benefits and positions after returning from training abroad.

Here’s a close look at career trajectories of researchers who train abroad & return to establish themselves in China. “The ‘first movers’ received many advantages & enjoyed a lot of autonomy. Newer recruits face greater competition & career pressures”
#AcademicSky 🧪

www.nature.com/articles/d41...

So glad I slept through whatever the hell this was

Expert Perspectives on Clinical Laboratory Accreditation for Polygenic Risk Scores Background Polygenic risk scores (PRS) are rapidly being translated into clinical practice to estimate risk to health conditions and inform health management. However, the lack of clear guidelines for...

Expert Perspectives on Clinical Laboratory Accreditation for Polygenic Risk Scores
www.medrxiv.org/content/10.1...

We were definitely saying "Manhattan plot" circa 2007... must have been shy about being so casual in print!