Pablo Pelegrin

Our method of identifying Highly Cited Researchers includes not only publication and citation counts but other considerations such as researchers’ community-wide impact, their contemporary influence and the production of original research. #HighlyCited2025

clarivate.com/academia-gov...

Honored to be selected as #HighlyCited2025 researcher by @clarivateag.bsky.social. Grateful for my present and past lab members, institutions and funding agencies who make our work possible.
@um.es

Honored to be selected as #HighlyCited2025 researcher by @clarivateag.bsky.social. Grateful for my present and past lab members, institutions and funding agencies who make our work possible.
@um.es

Honored to be selected as #HighlyCited2025 researcher by @clarivateag.bsky.social. Grateful for my present and past lab members, institutions and funding agencies who make our work possible.
@um.es
@erc.europa.eu
@horizoneu.bsky.social
@umudivulga.bsky.social

clarivate.com/highly-cited...

Today we announce the Highly Cited Researchers 2025 list—celebrating 6,868 individuals from over 1,300 institutions across 60 countries. #HighlyCited2025

Read the full press release: clarivate.com/news/clariva...

#ToPrimeOrNotToPrime, this is the question! Excited for our new review @cp-trendsimmuno.bsky.social with @oceanedufies.bsky.social in which we discuss what is “priming” for the #NLRP3 #inflammasome & how we can harness this knowledge to better control human diseases! #InflammasomePower! #Free 👇👇👇

#Nature #NewsFeature 7 basic science discoveries that changed the world. Ozempic, MRI machines and flat screen televisions all emerged out of fundamental research decades earlier. www.nature.com/articles/d41... cc @lluismontoliu.bsky.social

Chronic sensing of host-derived lipids is an all-in-one signal that primes and activates NLRP3. Activation of the NLRP3 inflammasome leads to the production of bioactive interleukin (IL)-1β fostering atherosclerosis. The current dogma is that NLRP3 must be first primed by microbial stimuli, know...

#InflammasomePower! 💥New paper alert💥 How is NLPR3 primed & activated in chronic non-communicable inflammatory diseases? With @oceanedufies.bsky.social &co we show that chronic exposure to oxPAPC drives NRF2 activation that primes & activates NLRP3 sustaining #atherosclerosis in mice & humans! 👇👇👇

#SpookyInflammasome 🎃
With @lozanzi.bsky.social &co, we show that sustained NRF2 activation by endogenous oxidized phospholipids primes and activates the NLRP3 inflammasome 🔥 to drive atherosclerosis.
... more to come on the priming !

Thank you to our editor, Kirsty Minton, and the staff at NRI for the opportunity to share our thoughts on this emerging topic.

Fantastic new story @jkagan1.bsky.social & friends showing that human dendritic cells can become hyperactive activating the inflammasome without dying, & that this approach can be used in mice and NHPs to potentiate anti-influenza vaccine responses! 👇👇👇

Looking for passionate candidate to apply to PhD fellowship to University of Murcia call:

www.um.es/documents/d/...

Interested students contact me!

Intrahepatic donor microbiota-based metataxonomic signature detected in organ preservation solution enables prediction of short-term liver transplant outcomes | Alberto Baroja-Mazo Thrilled to share that our latest work has just been published in Gut 🚀 We show that donor intrahepatic microbial DNA signatures, detected in organ preservation solution, can predict post-transplant o...

www.linkedin.com/posts/albert...

Cheng, Qiu et al @jhu.edu provide new insights into the molecular mechanism of #phagosome maturation and the dynamics of host defense response following phagosome-mediated bacterial degradation in peritoneal #macrophages. rupress.org/jem/article/...

#InnateImmunity #inflammation #InfectiousDisease

So excited that this study is now online! It's been a pleasure to work with BioAge Labs and our collaborators on this story. We characterise a new class of #NLRP3 inhibitors with translational potential for so many inflammatory diseases.

#NLRP3 is a target for antiinflammatory therapies & can be inhibited by the tool compound MCC950. Wilhelmsen, @colllab.bsky.social et al characterize new small-molecule inhibitors, BAL-0028 & BAL-0598, that have a distinct mechanism of action & binding site. rupress.org/jem/article/...
#Inflammasome

Review @natimmunol.nature.com
The expanding role of the NLRP3 inflammasome from periodic fevers to therapeutic targets
www.nature.com/articles/s41...

#InterferonPower! Thrilled for our latest work @cp-cell.bsky.social! With @danielboehmer.bsky.social, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free👉 authors.elsevier.com/a/1leKGL7PXu...

🚨It’s out @embojournal.org 🚨
Cardiolipin inhibits Caspase-4/11!
Huge thanks to my brilliant supervisors Kate & Pablo, to @s-burgener.bsky.social & Mercedes and all the @inflammasomelab.bsky.social, it was a joy working and laughing with you, and to @brozlab.bsky.social & Si Ming lab.

Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells Nature Immunology - Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate...

Have you ever wondered whether pyroptotic corpses have functions beyond the grave? We made the surprising discovery that pyroptotic corpses are flagged by #filopodia to alert #DendriticCells they need autopsy. A short Bluetorial (1/13)👇with movies!
Link: rdcu.be/d2mjm